Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation

Abstract

Thyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroidism. The long-term monitoring of thyroid function, T-cell populations, and cytomegalovirus after HSCT is important.

The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt

“…Many other organisms such as Acinetobacter, Mycobacterium, Coccidioides, Pseudomonas, Eikenella, Clostridium, Nocardia, Pneumocystis carnie, Haemophilus, and Candida have been isolated, but mostly associated with immunosuppression [12]. Oka et al detected infection with CMV associated with hyperthyroidism after transplantation due to a reversed imbalance in helper/suppressor T cell populations and B cell dysregulation [13]. Similar results observed by Maawali et al regarding the cause of infective thyroiditis could be due to CMV [14].…”

“…Oka et al detected infection with CMV associated with hyperthyroidism after transplantation due to a reversed imbalance in helper/suppressor T cell populations and B cell dysregulation [ 13 ]. Similar results observed by Maawali et al regarding the cause of infective thyroiditis could be due to CMV [ 14 ].…”