The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt

Abstract

Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of thyroid dysfunction in MS and to investigate the association between DMDs and the risk of thyroiditis in MS. A cross-sectional study included 100 patients with relapsing-remitting multiple sclerosis (RRMS) in relapse, and the diagnosed was according to revised McDonald’s criteria 2010. Results Our results revealed that the prevalence of thyroiditis was 40%; autoimmune (34%) and infective (6%) among patients with RRMS in relapse and cerebellar symptoms were significantly higher in patients with thyroiditis compared to patients without thyroiditis. Regarding the association between DMDs and thyroiditis, the prevalence of patients treated with interferon-beta-1b was higher in MS patients with thyroiditis compared to MS patients without thyroiditis. However, the prevalence of patients treated with interferon-beta-1a was lower in MS patients with thyroiditis compared to MS patients without thyroiditis. In addition, we found CMV infection was more common in patients treated by interferon beta-1b and candida infection was common in patients treated by fingolimod. Conclusions Thyroiditis is commonly observed in patients with RRMS in relapse and higher prevalence of patients treated with interferon-beta-1b which is commonly associated with thyroiditis and CMV infection; however, candida thyroid infection was common in MS patients treated by fingolimod.

Knowledge Assessment Regarding the Differences Between Hypothyroidism and Hyperthyroidism Among Saudi Arabia’s Adult Population

“…Thyroid disorders are on the rise globally [11], and certain strata of society are more heavily affected than others [12]. The Kingdom of Saudi Arabia is not an exception; therefore, we aimed to conduct this study to have an up-to-date overview of the thyroid disease burden in this country and to have the necessary data to tackle the points of weakness that allow for an accelerated deterioration of the situation.…”

Stability of Thyroid Function Test Analytes Whose Serum Levels Are Determined by Immunoassay

“…Thyroid dysfunction is one of the most common endocrine disorders seen in clinical practice and represents approximately 30-40% of the patients seen in an endocrine clinic 13 . In addition, thyroid dysfunction can affect metabolic, cardiovascular, and neurologic function, and recent studies have reported subclinical thyroid anomalies to approach over 40% 14 . Furthermore, thyroid study "add-ons" represent a substantial component of the clinical chemistry and endocrinology testing in both inpatient (3 percent) and outpatient (8 percent) facilities 5 .…”