Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels

Regmi, Rajesh; Bhattarai, Shanta Raj; Sudakar, C.; Wani, Amit; Cunningham, Robert E.; Vaishnava, P. P.; Naik, R.; Oupický, David; Lawes, G.

doi:10.1039/c0jm00844c

Cited by 70 publications

(60 citation statements)

References 28 publications

(32 reference statements)

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“…Most of the studies dealing with hybrid magnetic PNIPAAm microgels need an intermediate step of surface-functionalization of the magnetic nanoparticles like the copolymerization of the PNIPAAm to enhance the compatibility or even an in-situ preparation of magnetic nanoparticles inside formed microgels [22,[27][28][29][30]. However, Jaiswal et al used chitosan, a natural biocompatible, biodegradable and pH sensitive polycationic polymer, to produce a hybrid magnetic PNIPAAm microgel without previous treatments.…”

Section: Introductionmentioning

confidence: 96%

One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

et al. 2015

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Section: Introductionmentioning

confidence: 96%

One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

et al. 2015

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“…Thus, our results indicate that the release of BSA in response to AMF application was induced by the deswelling of gelatin/p(NIPAM-co-AAm)/MNPs microgel, associated with the shrinkage of p(NIPAM-co-AAm) polymer chains within the microgel (Figure 3). Since the extent of microgel deswelling is proportional to the both extent of temperature increase and concentration of p(NIPAM-co-AAm) 8 , a strategy to increase either amount of MNPs 24 or p(NIPAM-co-AAm) 8 in step 1 in the protocol section may result in increased release of BSA at a given field strength and frequency of AMF application. …”

Section: Representative Resultsmentioning

confidence: 99%

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Sung

Shaffer

Sittek

et al. 2016

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Magnetically-responsive nano/micro-engineered biomaterials that enable a tightly controlled, on-demand drug delivery have been developed as new types of smart soft devices for biomedical applications. Although a number of magnetically-responsive drug delivery systems have demonstrated efficacies through either in vitro proof of concept studies or in vivo preclinical applications, their use in clinical settings is still limited by their insufficient biocompatibility or biodegradability. Additionally, many of the existing platforms rely on sophisticated techniques for their fabrications. We recently demonstrated the fabrication of biodegradable, gelatin-based thermo-responsive microgel by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within a three-dimensional gelatin network. In this study, we present a facile method to fabricate a biodegradable drug release platform that enables a magneto-thermally triggered drug release. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and thermo-responsive polymers within gelatin-based colloidal microgels, in conjunction with an alternating magnetic field application system. Video LinkThe video component of this article can be found at

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“…With respect to this swelling phenomenon and the intrinsic ''sponge-like'' network structures of microgel particles in their expanded state, previous literatures have reviewed the potential for diffusive encapsulation and release of active species from thermo-sensitive poly(N-isopropylacrylamide)-based polyelectrolyte microgel systems [10][11][12]. They are found advantageous in a vast array of novel applications including the fabrication of photonic crystals [13], separation technologies [14,15], catalysis [16,17], and as promising controlled drug delivering agents [18][19][20].…”

Section: Introductionmentioning

confidence: 98%