Hyperthermia and radiation therapy of local-regional recurrent breast cancer: Prognostic factors for response and local control of diffuse or nodular tumors

“…The risk of locoregional recurrence following surgery alone increases with the extent of axillary involvement, and loco-regional recurrence rates range from 22% to 27% in patients with positive axillary lymph nodes. 7 Significant morbidity, such as ulceration, bleeding, and pain caused by locoregional recurrence is devastating to the patients' quality of life. Thereby, local control should be considered to be as important as systemic therapy to palliate the patients' suffering.…”

Section: Discussionmentioning

confidence: 99%

Local hyperthermia combined with external irradiation for regional recurrent breast carcinoma

et al. 2004

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The present findings suggested a significant benefit of local hyperthermia combined with radiotherapy in the treatment of locally recurrent breast cancer, especially for previously irradiated recurrence, by reducing the total irradiation dose. Diffuse/multiple small nodular tumors respond earlier than bulky/large nodular tumors; however, they tend to recur within the treatment field. The purpose of this study was to evaluate the therapeutic effects of hyperthermia in combination with radiotherapy for locoregional recurrence of breast cancer, and to assess the factors related to subsequent local tumor control.

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“…Although such doses result in the destruction of cancer cells with a relatively high probability of 40 to 100 %, they do not completely prevent undesirable side effects that can occur with a probability of 20 to 90 %, 1-3. In order to minimize these side effects, lower doses of radiation are required, which can be obtained by sensitizing the tumor cells, using for example hyperthermia, 8.…”

Section: Treatments Commonly Used To Treat Breast Cancermentioning

confidence: 99%

Perspectives of Breast Cancer Thermotherapies

Alphandéry¹

2014

J. Cancer

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In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carried out alone to eradicate small breast tumors. A recently developed thermotherapy, called magnetic hyperthermia, which involves localized heating of nanoparticles under the application of an alternating magnetic field, is also presented. The advantages and drawbacks of these different thermotherapies are highlighted.

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Hyperthermia and radiation therapy of local-regional recurrent breast cancer: Prognostic factors for response and local control of diffuse or nodular tumors

Cited by 62 publications

References 65 publications

Effect of combined therapy with the antiestrogen agent toremifene and local hyperthermia on breast cancer cells implanted in nude mice

Effect of combined therapy with the antiestrogen agent toremifene and local hyperthermia on breast cancer cells implanted in nude mice

Local hyperthermia combined with external irradiation for regional recurrent breast carcinoma

Perspectives of Breast Cancer Thermotherapies

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