Hypertensive Schwangerschaftserkrankungen und
                    SARS-CoV-2/COVID-19: Auswertung des nationalen
                    CRONOS-Registers

Zöllkau, Janine; Bohlmann, Michael K.; Mingers, Nina; Pecks, Ulrich; Weschenfelder, F; Groten, T

doi:10.1055/a-1962-6964

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Information on the study is available at www.dgpm-online.org and the German Clinical Trials Register (DRKS00021208). Methodology and study results have been published recently [6,11,12,13,14,15,16,17]. Approval of the Institutional Ethics Board was obtained for the study (University Hospital Schleswig-Holstein in Kiel, file number D 451/20) and for each study site separately.…”

Section: Study Design and Settingmentioning

confidence: 99%

Multiple Gestation as a Risk Factor for SARS-CoV-2-Associated Adverse Maternal Outcome: Data From the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS)

Sourouni,

Germeyer,

Feißt

et al. 2023

Geburtshilfe Frauenheilkd

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Studies have shown that pregnant women with COVID-19 have a higher risk of intensive care unit admission and invasive mechanical ventilation support than non-pregnant women. Pregnancy-associated physiological changes in respiratory function may contribute to the elevated risk. Alteration in lung volumes and capacities are attributed to the mechanical impediment caused by the growing fetus. Multiple pregnancies may therefore compromise functional lung capacity earlier than singleton pregnancies and contribute to severe respiratory symptoms of COVID-19.A total of 5514 women with a symptomatic SARS-CoV-2 infection during pregnancy registered in the COVID-19 Related Obstetric and Neonatal Outcome Study were included. The COVID-19-related adverse maternal outcomes were compared in 165 multiple versus 5349 singleton pregnancies. Combined adverse maternal outcome was defined as presence of COVID-19-related hospitalization and/or pneumonia and/or oxygen administration and/or transfer to ICU and/or death. Multivariate logistic regression was used to estimate the odds ratios and 95% confidence intervals were calculated.The frequency of dyspnea, likelihood of developing dyspnea in a defined pregnancy week and duration of the symptomatic phase of the COVID-19 infection did not differ between the two groups. On average, COVID-19-related combined adverse outcome occurred earlier during pregnancy in women expecting more than one child than in singleton pregnancies. The overall incidence of singular and combined COVID-19-associated adverse maternal outcomes was not significantly different between groups. However, regression analysis revealed that multiple gestation, preconceptional BMI > 30 kg/m2 and gestational age correlated significantly with an increased risk of combined adverse maternal outcome. Conversely, maternal age and medically assisted reproduction were not significant risk factors for combined adverse maternal outcome.Our data show that multiple gestation alone is a risk factor for COVID-19-associated combined adverse maternal outcome. Moreover, severe courses of COVID-19 in women expecting more than one child are observed earlier in pregnancy than in singleton pregnancies.

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Section: Study Design and Settingmentioning

confidence: 99%

Multiple Gestation as a Risk Factor for SARS-CoV-2-Associated Adverse Maternal Outcome: Data From the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS)

Sourouni,

Germeyer,

Feißt

et al. 2023

Geburtshilfe Frauenheilkd

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“…More information on the study is available at , accessed on 30 December 2022. Data from the study with a focus on other issues (maternal comorbidities or neonatal aspects) have been recently published [ 8 , 10 , 11 , 12 , 13 ]. Ethical approval was given by the local Ethical Committee (University Hospital Schleswig-Holstein, Kiel, file no.…”

Section: Methodsmentioning

confidence: 99%

Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network)

Weschenfelder

Zöllkau

Schohe

et al. 2023

JCM

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(1) Background: Obesity is an increasing challenge in the care of pregnant women. The aim of our study was to investigate whether obesity is an independent risk factor for severe maternal and neonatal outcomes in pregnant women with COVID-19. (2) Methods: Data from the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was used to analyze the effect of obesity on selected individual and combined outcome parameters (3) Results: With 20.1%, the prevalence of obesity in the CRONOS registry exceeds the German background rate of 17.5%. Obese women showed significantly higher rates of GDM (20.4% vs. 7.6%; p < 0.001), hypertensive pregnancy disorders (6.2% vs. 2%; p = 0.004) and C-sections (50% vs. 34.5%; p < 0.001). BMI was revealed to be an individual risk factor for the severe combined pregnancy outcome (maternal death, stillbirth or preterm birth < 32 weeks) (OR 1.050, CI 1.005–1.097). (4) Conclusions: Maternal BMI is a predictor for the most severe outcome as maternal or neonatal death and preterm delivery <32 weeks of gestation. Unexpectedly, categorized obesity seems to have limited independent influence on the course and outcome of pregnancies with COVID infections.

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“…Unter Beteiligung aller Mitglieder und Kliniken erfolgte die erste zitierfähige Publikation aus CRONOS im Oktober 2020. Zu diesem Zeitpunkt waren es lediglich 247 Frauen, die Eingang in die Studie fanden [4]; nur konsequent, dass mit den anschließenden 8000 weiteren Dateneingängen zahlreiche auch international beachtete Publikationen unter verschiedener Federführung folgen mussten [5][6][7][8][9][10][11]. In der aktuellen Ausgabe der ZGN finden sich Arbeiten aus den innerhalb des CRONOS-Forschungsnetzwerks gebildeten Task Forces zu Diabetes (S. 17-31), zur fetalen Entwicklung und Fehlentwicklung (S. 57-64, S. 65-73), zum Stillen in der Pandemie (S. 88-96) sowie erste Ergebnisse zum Langzeit-Follow-up der Frauen und ihrer Kinder (S. 74-79 und S. 97-101).…”

Section: Transparente Wissenschaftskultur Und Kommunikation!unclassified

Zum Themenschwerpunkt „Erfahrungen aus der Pandemie – ein datenbasierter Rückblick“

Pecks

2024

Z Geburtshilfe Neonatol

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Die Menschheit in einer globalisierten Welt war in der Vergangenheit mit verschiedenen Herausforderungen konfrontiert, die gravierende Auswirkungen auf das tägliche Leben, die Wirtschaft und die Gesundheitssysteme hatten. Genannt seien die Spanische Grippe 1918–1919, die Ölkrise der 1970er-Jahre mit der Folge einschneidender Maßnahmen wie Energieeinsparungen und Rationierung, die AIDS-Pandemie oder die Finanzkrise und Wirtschaftsrezession von 2008.

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Hypertensive Schwangerschaftserkrankungen und SARS-CoV-2/COVID-19: Auswertung des nationalen CRONOS-Registers

Cited by 5 publications

References 17 publications

Multiple Gestation as a Risk Factor for SARS-CoV-2-Associated Adverse Maternal Outcome: Data From the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS)

Multiple Gestation as a Risk Factor for SARS-CoV-2-Associated Adverse Maternal Outcome: Data From the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS)

Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network)

Zum Themenschwerpunkt „Erfahrungen aus der Pandemie – ein datenbasierter Rückblick“

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