Hypertensive Disorders of Pregnancy and Cardiometabolic Health in Adolescent Offspring

Fraser, Abigail; Nelson, Scott M.; Macdonald‐Wallis, Corrie; Sattar, Naveed; Lawlor, Debbie A.

doi:10.1161/hypertensionaha.113.01513

Cited by 134 publications

(135 citation statements)

References 23 publications

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“…[9][10][11] Several studies have shown an association between maternal preeclampsia and elevated blood pressure (BP) in the offspring during childhood and adolescence. [12][13][14][15][16][17][18][19] Other studies have reported on glucose metabolism in the offspring of mothers with preeclampsia. [20][21][22] The aim of the present study was to determine, using the Quantitative Insulin Sensitivity Check Index (QUICKI), whether preeclampsia influences insulin sensitivity (IS) in the offspring of affected mothers.…”

Section: Resultsmentioning

confidence: 99%

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Seppä

Voutilainen

Tenhola

2015

The Journal of Pediatrics

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Section: Resultsmentioning

confidence: 99%

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Seppä

Voutilainen

Tenhola

2015

The Journal of Pediatrics

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“…The results of 2 studies suggest that maternal preeclampsia and gestational hypertension may both be associated with higher blood pressure in adolescence, but their findings suggested no association with fasting insulin, glucose, lipid levels, apolipoproteins, or inflammatory markers. 28,29 An intriguing question is whether the adverse cardiovascular risk profile can be attributed to genetic or behavioral risk factors common to mothers and their offspring or to intrauterine vascular damage or altered metabolism caused by fetal exposure to hypertension or preeclampsia. [30][31][32] There is evidence that preeclampsia and CVD share similar risk factors 33 and that cardiovascular risk factors before pregnancy seem to be positively associated with preeclampsia risk.…”

Section: Discussionmentioning

confidence: 99%

Hypertension in Pregnancy and Offspring Cardiovascular Risk in Young Adulthood

et al. 2017

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H ypertensive disorders of pregnancy include gestational hypertension and preeclampsia.1 In addition to hypertension, preeclampsia is characterized by proteinuria and is a leading cause of maternal and perinatal morbidity. [2][3][4] It is well established that women with a history of hypertension in pregnancy are at increased risk of cardiovascular disease (CVD) later in life, [5][6][7][8] and their offspring may also have an increased lifetime risk of CVD.9-11 Children and adolescents whose mothers had preeclampsia seem to have higher body mass index (BMI) and blood pressure than others, but it is not entirely clear whether other cardiovascular risk factors, such as serum lipids, may also differ.12 Also, it remains to be determined whether siblings born after a hypertensive pregnancy differ in their cardiovascular profile compared with siblings born after a normotensive pregnancy. Such an analysis might help clarify whether the children's risk factors could be attributed to the hypertensive pregnancy or whether shared genes or shared lifestyle are equally relevant.Using a prospective cohort design, we investigated whether intrauterine exposure to maternal hypertensive disorders (gestational hypertension, term preeclampsia, or preterm preeclampsia) is associated with cardiovascular risk factors Abstract-Women with hypertensive disorders in pregnancy are at increased lifetime risk for cardiovascular disease. We examined the offspring's cardiovascular risk profile in young adulthood and their siblings' cardiovascular risk profile. From the HUNT study (Nord-Trøndelag Health Study) in Norway, 15 778 participants (mean age: 29 years), including 210 sibling groups, were linked to information from the Medical Birth Registry of Norway. Blood pressure, anthropometry, serum lipids, and C-reactive protein were assessed. Seven hundred and six participants were born after exposure to maternal hypertension in pregnancy: 336 mothers had gestational hypertension, 343 had term preeclampsia, and 27 had preterm preeclampsia. Offspring whose mothers had hypertension in pregnancy had 2.7 (95% confidence interval, 1.8-3.5) mm Hg higher systolic blood pressure, 1.5 (0.9-2.1) mm Hg higher diastolic blood pressure, 0.66 (0.31-1.01) kg/m 2 higher body mass index, and 1.49 (0.65-2.33) cm wider waist circumference, compared with offspring of normotensive pregnancies. Similar differences were observed for gestational hypertension and term preeclampsia. Term preeclampsia was also associated with higher concentrations of non-high-density lipoprotein cholesterol (0.14 mmol/L, 0.03-0.25) and triglycerides (0.13 mmol/L, 0.06-0.21). Siblings born after a normotensive pregnancy had nearly identical risk factor levels as siblings born after maternal hypertension. Offspring born after maternal hypertension in pregnancy have a more adverse cardiovascular risk profile in young adulthood than offspring of normotensive pregnancies. Their siblings, born after a normotensive pregnancy, have a similar risk profile, suggesting that shared genes or lifestyle...

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“…Children born to PE mothers are at higher risk of developing proteinuria, hypertension, CKD, metabolic syndrome and cardiovascular diseases [105][106][107][108][109]. Interestingly, these are the same diseases that are reported in the mothers, and the study group holds that not only the mothers but also the children should be followed in the long term, with modalities still to be clarified, also on the account of the organization of the health care system, and on the availability of general care or specialist care.…”

Section: Pe Occurring In Patients Without Any Previous or Present Sigmentioning

confidence: 99%

A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy

Piccoli

Cabiddu

Castellino³

et al. 2017

J Nephrol

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Preeclampsia (PE) is a protean syndrome causing a transitory kidney disease, characterised by hypertension and proteinuria, ultimately reversible after delivery. Its prevalence is variously estimated, from 3 to 5% to 10% if all the related disorders, including also pregnancy-induced hypertension (PIH) and HELLP syndrome (haemolysis, increase in liver enzyme, low platelets) are included. Both nephrologists and obstetricians are involved in the management of the disease, according to different protocols, and the clinical management, as well as the role for each specialty, differs worldwide. The increased awareness of the role of chronic kidney disease in pregnancy, complicating up to 3% of pregnancies, and the knowledge that PE is associated with an increased risk for development of CKD later in life have recently increased the interest and redesigned the role of the nephrologists in this context. However, while the heterogeneous definitions of PE, its recent reclassification, an emerging role for biochemical biomarkers, the growing body of epidemiological data and the new potential therapeutic interventions lead to counsel long-term follow-up, the lack of resources for chronic patients and the increasing costs of care limit the potential for preventive actions, and suggest tailoring specific interventional strategies. The aim of the present position statement of the Kidney and Pregnancy Study Group of the Italian Society of Nephrology is to review the literature and to try to identify theoretical and pragmatic bases for an agreed management of PE in the nephrological setting, with particular attention to the prevention of the syndrome (recurrent PE, presence of baseline CKD) and to the organization of the postpartum follow-up.

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Hypertensive Disorders of Pregnancy and Cardiometabolic Health in Adolescent Offspring

Cited by 134 publications

References 23 publications

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Hypertension in Pregnancy and Offspring Cardiovascular Risk in Young Adulthood

A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy

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