Hypertension, pregnancy and weather: is seasonality involved?

Melo, Brena Carvalho Pinto de; Amorim, Melânia Maria Ramos; Katz, Leila; Coutinho, Isabela; Figueirôa, José Natal

doi:10.1590/1806-9282.60.02.006

Cited by 18 publications

(14 citation statements)

References 16 publications

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“…Our region has a high preeclampsia prevalence as comparing to other regions. A previous study in our setting determined an incidence rate of 19.3% of hypertensive disorders of pregnancy [23]. This high incidence could be explained by magnesium deficit but our study with oral magnesium supplementation did not support this hypothesis.…”

Section: Discussioncontrasting

confidence: 89%

Magnesium supplementation and preeclampsia in low-income pregnant women – a randomized double-blind clinical trial

Araújo

Oliveira

Gusmão

et al. 2020

BMC Pregnancy Childbirth

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Background: Preeclampsia is the major cause of maternal morbidity and mortality in developing countries. Magnesium sulfate is considered first-line therapy against eclampsia and magnesium deficiency in pregnancy has been associated with unfavourable perinatal outcomes. However there are doubts if magnesium supplementation during pregnancy can previne preeclampsia especially in population with high nutritional risk. This trial aims to verify the effect of oral magnesium supplmentation on preeclampsia incidence in low income pregnant women.Methods: This randomized, double-blind, placebo-controlled trial investigated the effect of oral magnesium citrate supplementation for preeclampsia in low-income Brazilian pregnant women, i.e. annual per capita income of US$ 1025 or less. Participants were admitted to the study with gestational age between 12 and 20 weeks. Magnesium serum level was measured pre-randomization and participants with hypermagnesemia were excluded. After randomizationg participants received magnesium citrate capsule (300 mg magnesium citrate) or a daily placebo capsule, until delivery. Intent-to-treat analysis was performed.Results: A total of 416 pregnant women were screened and 318 enrolled according to the inclusion criteria; 159 for each arm. Twenty-eight pregnant women were lost to follow-up. 55/290 (18.9%) of pregnant women developed preeclampsia; 26/143 (18.1%) in magnesium group and 29/147 (19.7%) in the control group; OR 0.90 (CI 95% 0.48-1.69), p = 0.747. No cases of eclampsia were registered.Conclusion: Oral magnesium supplementation did not reduce preeclampsia incidence in low-income and low-risk pregnant women.

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Section: Discussioncontrasting

confidence: 89%

Magnesium supplementation and preeclampsia in low-income pregnant women – a randomized double-blind clinical trial

Araújo

Oliveira

Gusmão

et al. 2020

BMC Pregnancy Childbirth

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“…In Brazil, there have been some studies that associated seasonal temperature variation with gestational hypertension, 4,23 symptoms of stroke, 24,25 respiratory diseases, 26 epistaxis 27 and others that investigated the association between climate and mortality from different diseases in elderly individuals. 28 Only one study 29 approached the subject, when it investigated the effect of water temperature on cardiovascular responses: heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) during exercise at different temperatures (29° C, 33° C and 37° C).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Seasonal Temperature Variation on Blood Pressure Behavior

Escosteguy

Beskow

Sand

2019

International Journal of Cardiovascular Sciences

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Background: Hypertension in Brazil affects 32.5% of the population, accounting for 50% of deaths due to cardiovascular disease. The correct measurement and interpretation of blood pressure are essential for attaining an adequate disease diagnosis and management.Objective: To verify the correlation between the seasonal temperature variation during 2016 and blood pressure variation in 902 patients of a private Cardiology Service in the city of Porto Alegre/RS. Method: A total of 902 ambulatory blood pressure monitoring (ABPM) results were analyzed in 2016. Pearson's Correlation Coefficient was used to correlate blood pressure levels with the values of temperature and relative air humidity; the Kolmogorov-Smirnov and Shapiro-Wilk tests were adopted for significance values, assuming an alpha error < 0.05 and a 95% confidence interval. The Analysis of Variance compared the 902 ABPM results with the continuous variables obtained for this study. Results:No statistically significant differences were found when the blood pressure values obtained from the 902 ABPM results were correlated with the minimum, mean and maximum values of temperature and relative air humidity, and also when each of the continuous variables obtained for this study were compared with these same pressure measurements. Conclusion:Despite the great variation in temperature and relative air humidity throughout the year in the region, there was no significant influence on the systemic arterial pressure in the study population. New comparative studies in the same population with different thermal variations may provide further clarification on this subject.

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“…O mesmo autor também não encontrou associação significativa entre temperatura média e mínima do dia da admissão e dos 3 dias que o antecederam, sendo esses achados semelhantes aos encontrados em nosso estudo. Em estudo recente realizado no Recife 15…”

Section: Discussionunclassified

“…Essas alterações poderiam sofrer influência dos fatores climáticos, e assim se justificaria o aumento na ocorrência de PE em baixas temperaturas [9][10][11][12][13][14] . Destacamos um estudo brasileiro 15 , realizado no Recife, no qual se observou uma maior a prevalência de DHEG nos meses mais frios.…”

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