Hypertension

Norwood, Victoria F.

doi:10.1542/pir.23-6-197

Cited by 38 publications

(69 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fifty percent of the population with essential hypertension is consistent with the reported prevalence in adolescent populations. 20 The majority of children with secondary hypertension had renal parenchymal scars leading to renin-mediated hypertension (32 children). Other etiologies included renal artery stenosis in 3 (2 of whom also had William's syndrome), pheochromocytoma (2 patients), coarctation of the aorta (2 patients), and 1 with the syndrome of apparent mineralocorticoid excess.…”

Section: Patient Populationmentioning

confidence: 99%

mentioning

confidence: 99%

“…The likelihood is greater among children diagnosed during adolescence or those with a significant family history for hypertension. 20 Children with primary hypertension are frequently obese (50%) and almost universally progress to adult hypertension. 20 In this report, we evaluated 125 consecutive children who were referred to the Baylor Pediatric Renal section with newly diagnosed hypertension.…”

mentioning

confidence: 99%

“…20 Children with primary hypertension are frequently obese (50%) and almost universally progress to adult hypertension. 20 In this report, we evaluated 125 consecutive children who were referred to the Baylor Pediatric Renal section with newly diagnosed hypertension. We hypothesized that the relation of serum uric acid to BP would be particularly strong in subjects with new-onset and untreated hypertension.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Hyperuricemia in Childhood Primary Hypertension

2003

View full text Add to dashboard Cite

Abstract-Experimental animal models suggest that uric acid might have a pathogenic role in the early development of primary hypertension. We hypothesized that serum uric acid is correlated with blood pressure in children with new-onset, untreated, primary hypertension. We evaluated 125 consecutive children referred to the Baylor Pediatric Renal Program for evaluation of hypertension. None of the subjects had previously been evaluated or treated for hypertension. The children ranged in age from 6 to 18 years (mean, 13.4Ϯ3.3) and had normal renal function (creatinine clearance Ͼ80 mL · min Ϫ1 · 1.73 m Ϫ2 ). Sixty-three children had primary hypertension, 40 had secondary hypertension, and 22 had white-coat hypertension. Forty controls with normal blood pressure were recruited from the renal clinic. Uric acid levels were directly correlated with systolic (rϭ0.80, Pϭ0.0002) and diastolic (rϭ0.66, Pϭ0.0006) blood pressure in controls and in subjects with primary hypertension and were independent of renal function. Serum uric acid concentrations Ͼ5.5 mg/dL were found in 89% of subjects with primary hypertension, in 30% with secondary hypertension, in 0% with white-coat hypertension, and in 0% of controls. We conclude that serum uric acid is directly correlated with blood pressure in untreated children and that a serum uric acid value Ͼ5.5 mg/dL in an adolescent being evaluated for hypertension strongly suggests primary hypertension as opposed to white-coat or secondary hypertension. These results are consistent with the hypothesis that uric acid might have a role in the early pathogenesis of primary hypertension. Key Words: uric acid Ⅲ hypertension, essential Ⅲ children Ⅲ renal disease H ypertension, the most common form of cardiovascular disease, is present in nearly 25% of adults and increases in prevalence with age. Hypertension results in increased morbidity and mortality by dramatically escalating the risk of myocardial infarction, congestive heart failure, stroke, peripheral vascular disease, and renal failure. 1,2 Several clinical and laboratory observations are consistent with the hypothesis that uric acid might be important in the development of primary hypertension in humans. An association of gout with hypertension was first noted in 1879. 3 Twenty-five percent to 40% of adult patients with untreated hypertension have hyperuricemia (Ͼ6.5 mg/dL), and many more have a high-normal serum uric acid value (5.0 to 6.5 mg/dL). 4,5 The relation between uric acid and blood pressure (BP) is continuous and is observed in both AfricanAmericans and whites. 6 Furthermore, hyperuricemia predicts the development of, and is an independent risk factor for, hypertension. 7,8 Finally, we demonstrated that hyperuricemic rats develop hypertension 9 followed by preglomerular arteriolopathy. 10 Early hypertension is dependent on the reninangiotensin system and nitric oxide pathways 9 ; however, once preglomerular vascular disease develops, hypertension is driven by the kidney, and lowering uric acid levels is no longer protective. 1...

show abstract

Section: Patient Populationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Hyperuricemia in Childhood Primary Hypertension

2003

View full text Add to dashboard Cite

show abstract

“…La HA es una patología sub diagnosticada en los niños, con una prevalencia de alrededor de un 2 a 3% [11][12] . A la luz de los conocimientos actuales se puede asegurar que la presión elevada tiene sus inicios en la niñez y en algunos casos incluso en la vida intrauterina, con tendencia a la perpetuación de los niveles de PA en el tiempo, es decir, que aquellos sujetos con valores de presión altos, tendrán en la edad adulta mayor riesgo de ser hipertensos que los niños con valores en los percentiles bajo 90 13 .…”

Section: Hipertensión Arterial En Pediatríaunclassified

Hipertensión arterial y consumo de sal en pediatría

F²

2009

Rev. chil. pediatr.

View full text Add to dashboard Cite

Arterial hypertension and salt intake in pediatricsPediatric arterial hypertension (AH) is an underdiagnosed disease, with a known prevalence of 2-3%. Its preventive management should begin early and includes life-style changes and diet salt reduction to a maximum of 5.8 g (2.3 g of sodium), since there is a direct relationship between total salt intake and arterial blood pressure. It has been previously shown that in populations with low salt diet (less than 3g), AH is rare and it does not increase with age. It has been estimated that 77% of salt found in regular diets comes from processed food. Mechanisms involved in salt intake and high blood pressure are analyzed in this paper. Arterial hypertension secondary to renal diseases and other pathologies are excluded. Considering renal physiology, the role of the kidney is crucial in arterial blood pressure regulation, through the capacity to affect the salt and water excretion; therefore, controlling total blood volume. The relationship between salt and AH in the newborn and older children, as well as genetic aspects of this disease, are discussed. In conclusion, there are biological and behavioural risk factors that can be modified in young population. It is necessary to promote these changes through active, as well as passive, prevention strategies. A government public health policy including educational publicity campaigns, permanent media information and accessible health food labelling is essential. Habits, old customs and trends need to be changed through a multifactorial approach to groups, families and community. The pediatrician should lead this effort. RESUMENLa hipertensión arterial (HA) en pediatría es una patología sub diagnosticada, con una prevalencia de alrededor de un 2 a 3%. Su prevención debe comenzar precozmente con indicaciones de estilos de vida saludables, en especial reducción de sodio a 2,3 g equivalentes a 5,8 g de cloruro de sodio diarios, dada la relación directa entre cantidad de sal de la dieta y la presión arterial. En poblaciones humanas con dietas conteniendo menos de 3 g de sal por día la HA es infrecuente y no aumenta con la edad. La mayor parte del sodio ingerido se aporta por los alimentos elaborados industrialmente: el 77% se obtiene de los alimentos ACTUALIDAD CLINICAL OVERVIEW Rev Chil Pediatr 2009; 80 (1): 11-20

show abstract

Hypertension in Children: An Overview

Pinto

Roldan

Sollecito

2006

Journal of Dental Education

View full text Add to dashboard Cite

Hypertension in children is an increasing concern for health care professionals. Updated guidelines for the treatment of hypertension in children and adolescents were published in 2004. This report reviews the epidemiology and management of pediatric hypertension and suggests an oral health protocol to apply to hypertensive children in the dental setting. A web search was performed using Medline, PubMed, ISI Citation Index, and Cochrane evidence-based databases for articles regarding hypertension in children published in English between 1998 and 2004. Relevant articles describing the epidemiology, classification, pathophysiology, and management of pediatric hypertension are discussed, and recommendations for dental treatment of pediatric patients are suggested. The incidence of pediatric hypertension can reach 5 percent. Data on the prevalence of pediatric hypertension in the dental setting is scarce. However, using the prevalence in the general population, at least fifty young patients will be hypertensive in a busy general or pediatric practice. Dental students and residents should have the opportunity to screen for hypertension during their training and familiarize themselves with the appropriate techniques in children. Oral health professionals should become aware of the implications of hypertension in children.

show abstract

Hypertension

Cited by 38 publications

References 0 publications

Hyperuricemia in Childhood Primary Hypertension

Hyperuricemia in Childhood Primary Hypertension

Hipertensión arterial y consumo de sal en pediatría

Hypertension in Children: An Overview

Contact Info

Product

Resources

About