Hypertension-induced reversible posterior leukoencephalopathy syndrome causing obstructive hydrocephalus

Lee, S.Y.; Dinesh, Shree Kumar; Thomas, John A.

doi:10.1016/j.jocn.2006.12.019

Cited by 22 publications

(9 citation statements)

References 8 publications

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“…3,4 An acute breakthrough of autoregulation may play an important role in acute hypertensive encephalopathy, eclampsia, and in acute brain injury. 5,6 CBF of the cerebral gray matter decreases with increasing age, [7][8][9][10][11][12][13][14][15] and the decrease of CBF might be explained by impaired cerebral autoregulation due to changes in endothelial function 16 or, alternatively, by a decrease in cerebral O 2 demand. Degenerative microvascular changes associated with normal aging 17 may also reduce the level of CBF in aging brains.…”

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confidence: 99%

Age-Related Changes of Cerebral Autoregulation: New Insights with Quantitative T2′-Mapping and Pulsed Arterial Spin-Labeling MR Imaging

Wagner¹,

Jurcoane²,

Volz

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Cerebral perfusion and O 2 metabolism are affected by physiologic age-related changes. High-resolution motion-corrected quantitative T2Ј-imaging and PASL were used to evaluate differences in deoxygenated hemoglobin and CBF of the gray matter between young and elderly healthy subjects. Further combined T2Ј-imaging and PASL were investigated breathing room air and 100% O 2 to evaluate age-related changes in cerebral autoregulation.

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confidence: 99%

Age-Related Changes of Cerebral Autoregulation: New Insights with Quantitative T2′-Mapping and Pulsed Arterial Spin-Labeling MR Imaging

Wagner¹,

Jurcoane²,

Volz

et al. 2012

AJNR Am J Neuroradiol

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“…In literature, PRES is most commonly not only described in association with hypertension[15] but also seen with infection (sepsis),[6] pregnancy,[78] and neurosurgical pathology. [910111213] In our patient, we believe that the development of PRES was directly related to the shunt insertion.…”

Section: Discussionmentioning

confidence: 99%

An unusual complication following ventriculoperitoneal shunting

Merola

Magdum

2017

J Pediatr Neurosci

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“…Nevertheless a small percentage (3–6%) will have an unfortunate outcome despite treatment [14, 23, 54, 55] such as intracranial hemorrhage, posterior fossa edema with brainstem compression or hydrocephalus, and diffuse cerebral edema with increased intracranial pressure [56, 57]. Hyperglycemia is an independent factor associated with poor outcome [14].…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury, Recurrent Seizures, and Thrombocytopenia in a Young Patient with Lupus Nephritis: A Diagnostic Dilemma

Verduzco

Acharya

2016

Case Reports in Nephrology

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Introduction. Posterior reversible encephalopathy syndrome (PRES) is a constellation of clinical and radiologic findings. Fluctuations in blood pressure, seizures, and reversible brain MRI findings mainly in posterior cerebral white matter are the main manifestations. PRES has been associated with multiple conditions such as autoimmune disorders, pregnancy, organ transplant, and thrombotic microangiopathy (TMA). Case Presentation. A 22-year-old woman with history of Systemic Lupus Erythematous complicated with chronic kidney disease secondary to lupus nephritis class IV presented with recurrent seizures and uncontrolled hypertension. She was found to have acute kidney injury and thrombocytopenia. Repeat kidney biopsy showed diffuse endocapillary and extracapillary proliferative and membranous lupus nephritis (ISN-RPS class IV-G+V) and endothelial swelling secondary to severe hypertension but no evidence of TMA. Brain MRI showed reversible left frontal and parietal lesions that resolved after controlling the blood pressure, making PRES the diagnosis. Conclusion. PRES is an important entity that must be recognized and treated early due to the potential reversibility in the early stages. Physicians must have high suspicion for these unusual presentations. We present a case where performing kidney biopsy clinched the diagnosis in our patient with multiple confounding factors.

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Hypertension-induced reversible posterior leukoencephalopathy syndrome causing obstructive hydrocephalus

Cited by 22 publications

References 8 publications

Age-Related Changes of Cerebral Autoregulation: New Insights with Quantitative T2′-Mapping and Pulsed Arterial Spin-Labeling MR Imaging

Age-Related Changes of Cerebral Autoregulation: New Insights with Quantitative T2′-Mapping and Pulsed Arterial Spin-Labeling MR Imaging

An unusual complication following ventriculoperitoneal shunting

Acute Kidney Injury, Recurrent Seizures, and Thrombocytopenia in a Young Patient with Lupus Nephritis: A Diagnostic Dilemma

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