Hypertension and Hypercholesterolemia are Associated with Cataract Development in Patients with Type 2 Diabetes

Tomić, Martina; R, Vrabec; Raštegorac, Petar; Ljubić, Spomenka; Bulum, Tomislav; Rahelić, Dario

doi:10.1007/s40292-021-00472-8

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…12 we previously observed that SBP is a risk factor for the development and progression of dr in t1dM, but in patients with normal renal function and normoalbuminura. 13 in contrast, we previously observed that dBP is a risk factor and predictor for cataract development in t2dM 14 .…”

Section: Introductionmentioning

confidence: 63%

Blood pressure is associated with diabetic retinopathy in type 1 but not in type 2 diabetes

Bulum

Tomić

et al. 2022

ACC

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The aim of this study was to investigate the role of systolic blood pressure (SBP) and diastolic blood pressure (dBP) in the development of diabetic retinopathy (dr) in type 1 and type 2 diabetes and to determine the differences between these two types of diabetes. This cross-sectional study included 84 patients with type 1 diabetes (t1dM) and 107 patients with type 2 diabetes (t2dM). Ophthalmologic retinal examination included indirect slit-lamp fundoscopy, color fundus photography according to eurOdiAB (eurOpe and diABetes) protocol and optical coherence tomography. Blood pressure was measured with a mercury sphygmomanometer after a 10-minute rest period. in t1dM, dr was positively associated with SBP (p = 0.035), hbA1c median (p < 0.001) and hypertensive retinopathy (p < 0.001), while in t2dM dr was positively related only to hbA1c median (p = 0.021). Binary logistic regression analysis (no dr/dr) showed that diabetes duration and hbA1c median were the main predictors of dr in both types of diabetes. in contrast, SBP (Or = 1.05, p = 0.045) and hypertensive retinopathy (Or = 3.75, p < 0.001) were the main predictors/indicators of dr only in t1dM. in conclusion, blood pressure is associated with dr in type 1 but not in type 2 diabetes.

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Section: Introductionmentioning

confidence: 63%

Blood pressure is associated with diabetic retinopathy in type 1 but not in type 2 diabetes

Bulum

Tomić

et al. 2022

ACC

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“…[ 24 ] Hypercholesterolemia has been directly related to the progression of T2DM. [ 28 , 29 ] Here, hypercholesterolemia prevalence correlates with the disease evolution between ED and LD groups. LD‐Si rats showed glycemia and insulinemia between the ED and LD groups, and no rats showed hypercholesterolemia, suggesting that Si‐RM intake slows down the evolution of T2DM.…”

Section: Discussionmentioning

confidence: 97%

Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late‐Stage Type 2 Diabetes Mellitus?

Hernández-Martín

Bocanegra

Redondo-Castillejo

et al. 2022

Molecular Nutrition Food Res

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Scope: Hypercholesterolemia increases the risk of mortality in type 2 diabetes mellitus (T2DM), especially in the late-stage. Consumption of bioactive compounds as functional ingredients would help achieve therapeutic goals for cholesterolemia. Silicon has demonstrated a hypocholesterolemic effect and the ability to reduce fat digestion. However, it is unclear whether silicon exerts such effect in late-stage T2DM (LD) and the intestinal mechanisms involved. Methods and results: Three groups of eight rats were included: early-stage T2DM control (ED), LD, and the LD group treated with silicon (LD-Si) once the rats were diabetic. Morphological alterations of the duodenal mucosa, and levels of markers involve in cholesterol absorption and excretion, beside cholesterolemia, and fecal excretion were assayed. Silicon included as a functional ingredient significantly reduces cholesterolemia in part due to: 1) reducing cholesterol intestinal absorption by decreasing the absorptive area and Acetyl-Coenzyme A acetyltransferase-2 (ACAT2) levels; and 2) increasing cholesterol excretion to the lumen by induction of the liver X receptor (LXR) and consequent increase of adenosine triphosphate-binding cassette transporter (ABCG5/8). Conclusions: These results provide insight into the intestinal molecular mechanisms by which silicon reduces cholesterolemia and highlights the efficacy of the consumption of silicon-enriched functional foods in late-stage T2DM.

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“…Martina Tomic et al 15 found Cataract was positively associated with diabetes duration (p = 0.001), HbA1c (p = 0.035), LDL cholesterol (p = 0.042), and DBP (p = 0.009), while negatively with creatinine clearance (p = 0.005). Diabetes duration and various metabolic risk factors, particularly poor glycemic control, hypercholesterolemia, DBP, and diabetic nephropathy's coexistence, are associated with cataract development in T2DM.…”

Section: Discussionmentioning

confidence: 98%

Association of serum lipid level with age related cataract in north western Rajasthan

Gupta,

Manoher,

Chauhan

et al. 2024

IJCEO

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: The aim of the study was to evaluate whether serum lipids levels are associated with incidence and type of age related cataract (ARC).: This was a analytical observational study conducted at Department of Ophthalmology of S.P. Medical College and Associated Group of Hospitals, Bikaner, Rajasthan, India. A random sample size of 200 subjects who met the inclusion criteria was recruited.: Data were analyzed and statistically evaluated using SPSS-PC-25 version.In the present study we found that mean age for control group was 50.84 years and 60.91 years for case group. In control group 69% male patients were seen while in case group 53% male patients were present. The mean Serum CHO level was found to be 204.66 ± 50.76 mg/dl in control subjects and it was found to be 226.63 ± 59.63 mg/dl in the subjects with age-related cataract (ARC). The mean Serum TG level was found to be 113.70 ± 59.92 mg/dl in control subjects and it was found to be 149.35 ± 68.12mg/dl in the subjects with age-related cataract (ARC). The mean Serum HDL level was found to be 58.65 ± 15.25 mg/dl in control subjects and it was found to be 53.12 ± 11.28 mg/dl in the subjects with age-related cataract (ARC). Our study found association between serum lipid profiles with age related cataract in the population. Our findings indicate a need for health promotional activities and health care access for controlling this modifiable factor among the ageing population of the country.

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Hypertension and Hypercholesterolemia are Associated with Cataract Development in Patients with Type 2 Diabetes

Cited by 10 publications

References 32 publications

Blood pressure is associated with diabetic retinopathy in type 1 but not in type 2 diabetes

Blood pressure is associated with diabetic retinopathy in type 1 but not in type 2 diabetes

Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late‐Stage Type 2 Diabetes Mellitus?

Association of serum lipid level with age related cataract in north western Rajasthan

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