Hypertension

Bhagani, Shradha; Kapil, Vikas; Lobo, Melvin D.

doi:10.1016/j.mpmed.2018.06.009

Cited by 20 publications

(14 citation statements)

References 8 publications

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“…First, over a 7-year period, the probability of progressing from normal/elevated BP to an adjacent state, that is, stage 1 hypertension was 19%, greater than progressing to a non-adjacent state, stage 2 hypertension which was 16.9%. Since an individual can be at a single state at a particular time point ( 24 ), the probabilities for stage 1 and stage 2 hypertension are indicative of the high risk of potential disease outcomes and the consistency of our findings with more recent studies showing an increase in the prevalence of hypertension ( 34 ).…”

Section: Discussionsupporting

confidence: 85%

Measuring Hypertension Progression With Transition Probabilities: Estimates From the WHO SAGE Longitudinal Study

Boateng

Lartey

Baiden

et al. 2021

Front. Public Health

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This paper assessed the transition probabilities between the stages of hypertension severity and the length of time an individual might spend at a particular disease state using the new American College of Cardiology/American Heart Association hypertension blood pressure guidelines. Data for this study were drawn from the Ghana WHO SAGE longitudinal study, with an analytical sample of 1884 across two waves. Using a multistate Markov model, we estimated a seven-year transition probability between normal/elevated blood pressure (systolic ≤ 129 mm Hg & diastolic <80 mm Hg), stage 1 (systolic 130-139 mm Hg & diastolic 80-89 mm Hg), and stage 2 (systolic ≥140mm Hg & diastolic≥90 mm Hg) hypertension and adjusted for the individual effects of anthropometric, lifestyle, and socio-demographic factors. At baseline, 22.5% had stage 1 hypertension and 52.2% had stage 2 hypertension. The estimated seven-year transition probability for the general population was 19.0% (95% CI: 16.4, 21.8) from normal/elevated blood pressure to stage 1 hypertension, 31.6% (95% CI: 27.6, 35.4%) from stage 1 hypertension to stage 2 hypertension, and 48.5% (45.6, 52.1%) for remaining at stage 2. Other factors such as being overweight, obese, female, aged 60+ years, urban residence, low education and high income were associated with an increased probability of remaining at stage 2 hypertension. However, consumption of recommended servings of fruits and vegetables per day was associated with a delay in the onset of stage 1 hypertension and a recovery to normal/elevated blood pressure. This is the first study to show estimated transition probabilities between the stages of hypertension severity across the lifespan in sub-Saharan Africa. The results are important for understanding progression through hypertension severity and can be used in simulating cost-effective models to evaluate policies and the burden of future healthcare.

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Section: Discussionsupporting

confidence: 85%

Measuring Hypertension Progression With Transition Probabilities: Estimates From the WHO SAGE Longitudinal Study

Boateng

Lartey

Baiden

et al. 2021

Front. Public Health

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“…[8,9] Hypertension is the largest risk factor associated with mortality worldwide. [10] Therefore, a medication can effectively reduce blood pressure, but synthetic antihypertensive drugs can lead to serious adverse side effects. The widely used are angiotensin converting enzyme (ACE) inhibitors, an enzyme widely distributed, zinc-dependent metallopeptidase that converts angiotensin I to angiotensin II.…”

Section: Introductionmentioning

confidence: 99%

“…Hypertension is the largest risk factor associated with mortality worldwide [10] . Therefore, a medication can effectively reduce blood pressure, but synthetic antihypertensive drugs can lead to serious adverse side effects.…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Santos

Soares

Beltrame

et al. 2021

Chemistry & Biodiversity

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The present study investigates the chemical composition, anti-inflammatory, and antihypertensive activities, in vitro, from extracts of Cuphea lindmaniana and Cuphea urbaniana leaves. The extraction was performed ultrasound-assisted, and UHPLC/MS analysis was in positive mode ionization. The anti-inflammatory activity of the extracts and miquelianin were assayed at concentrations 0.001 -10 μg/mL by chemotaxis on rat polymorphonuclear neutrophils. The antihypertensive activity was performed by angiotensin-converting enzyme (ACE) inhibition. From the nineteen proposed compounds, six of them are described for the first time in this genus. The extracts displayed antichemotactic effect with a reduction of 100 % of the neutrophil migration, in vitro, in most concentrations. The ACE-inhibition presented results ranging from 19.58 to 22.82 %. In conclusion, C. lindmaniana and C. urbaniana extracts contain a rich diversity of flavonoids and display in vitro anti-inflammatory and antihypertensive potential. Thus, this study could serve as a scientific baseline for further investigation, on developmental novel products with therapeutic actions.

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“…Hypertension is very important health problem causing death around the World, and it is associated with coronary diseases [1]. Pathogenesis of this disease has indicated that the angiotensin-converting enzyme (ACE) is a powerful regulator for the balance of blood pressure [2].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Coriandrum sativum L. and Chaerophyllum macropodum Boiss. (Apiaceae) on human plasma angiotensin-converting enzyme (ACE) in vitro

Çelikezen

Türkoğlu

Fırat

et al. 2021

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

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Hypertension is a very important problem around the world. The inhibition of the Angiotensin-converting enzyme (ACE, EC.3.4.15.1.) is regarded as fundamental of hypertension treatment. However, synthetic ACE inhibitors have several side effects. For this reason, there are lots of studies to improve green ACE inhibitors. Therefore, this study was designed to determine the potential inhibitory effects of two members of Apiaceae, Coriandrum sativum and Chaerophyllum macropodum, on human plasma ACE. For this purpose, water extracts of the plants were used. ACE inhibition activity was detected spectrophotometrically. Both plant extracts showed an inhibitory effect on ACE activity. The obtained results showed that Coriandrum sativum and Chaerophyllum macropodum have inhibitory effects on human plasma ACE with an IC50 value of 0.7 mg/mL and 1.14 mg/mL, respectively. Lineweaver-Burk graph was used to determine the inhibition type. The inhibition types were found as reversible noncompetitive. According to the obtained results, Coriandrum sativum and Chaerophyllum macropodum are valuable functional food with ACE inhibition capacity which may be used to balance blood pressure efficiently.

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Hypertension

Cited by 20 publications

References 8 publications

Measuring Hypertension Progression With Transition Probabilities: Estimates From the WHO SAGE Longitudinal Study

Measuring Hypertension Progression With Transition Probabilities: Estimates From the WHO SAGE Longitudinal Study

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

The Effects of Coriandrum sativum L. and Chaerophyllum macropodum Boiss. (Apiaceae) on human plasma angiotensin-converting enzyme (ACE) in vitro

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