Hypersensitivity to pituitary snuff with miliary shadowing in the lungs.

Vasopressin Analogue DDAVP in Diabetes Insipidus: Clinical and Laboratory Studies

“…Furthermore, for effective chlorpropamide therapy some functioning posterior pituitary must remain, and in many patients the "Antabuse"-like actions of chlorpropamide are unacceptable. Synthetic lysine vasopressin (LVP) given as a nasal spray has advantages over pituitary snuff in that it does not result in local hypersensitivity phenomena (Pepys et al, 1965) or pulmonary complications (Mahon et al, 1967). Its effects, however, are too short-lasting to be useful in patients with severe diabetes insipidus.…”

Demonstration of Circulating Antibodies to Neurophysin in Patients Treated With Pitressin

“…It is known that nasal insufflation of 'pituitary snuff' (acetone-dried posterior pituitary tissue) can result in the production of antibodies to its protein constituents (Pepys, Jenkins, Lachman & Mahon, 1965;Mahon, Scott, Ansell, Manson & Fraser, 1967). However, when more purified preparations are used, hypersensitivity reactions are uncommon.…”

Mediastinal and retroperitoneal fibrosis with fibrotic pulmonary nodules: a case report

“…Pituitary snuff is known to cause extrinsic allergic alveolitis (Pepys et al 1966, Mahon et al 1967), but our patient was symptomless, and the chest radiograph did not become abnormal until three years after he had switched from pituitary snuff to vasopressin nose drops.…”