Hypersensitivity to aloe

Morrow, D. M.

doi:10.1001/archderm.116.9.1064

Cited by 37 publications

(25 citation statements)

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“…But others give indications for caution (Atherton, 1998), indications of an inconclusive data (Vogler and Ernst, 1999;Ernst et al, 2002), contradictory results (Kaufman et al, 1988;Schmidt and Greenspoon, 1991) or toxic consequences resulting from the use of aloe gel (Morrow Figure 1 Mean number of papulopustules counted on subjects' faces relative to baseline counts (%) on Days 3 and 7 of treatment with test preparations, placebo and controls. et al, 1980;Avila et al, 1997;Hunter and Frumkin, 1991). The present study has followed up on the promising clinical literature reports of efficacy of aloe gel in pathologic skin conditions.…”

Section: Discussionmentioning

confidence: 99%

“…A 0.5% aloe vera extract in a hydrophilic cream, for instance, was found more effective than placebo, eliciting neither toxicity nor side effects in a 60-patient randomized controlled clinical study that investigated the management of Psoriasis vulgaris with aloe extract (Syed et al, 1996). However, contradictory results have been occasionally encountered, such as a case of adverse (hypersensitivity) side effect (Morrow et al, 1980) and delay in wound healing in both animal and human experiments (Kaufman et al, 1988;Schmidt and Greenspoon, 1991).…”

Section: Introductionmentioning

confidence: 99%

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The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf – a preliminary clinical investigation

Orafidiya

Agbani

Oyedele

et al. 2004

International Journal of Aromatherapy

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf – a preliminary clinical investigation

Orafidiya

Agbani

Oyedele

et al. 2004

International Journal of Aromatherapy

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“…Acute hepatitis could be linked to ingestion of Aloe barbdensis compounds. An acute bullous allergic reaction and urticaria have also been reported to result from the use of aloe vera gel (Morrow et al 1980).…”

Section: Aloe Powder and Its Food Applicationsmentioning

confidence: 99%

Processing, food applications and safety of aloe vera products: a review

Ahlawat¹,

Khatkar²

2011

J Food Sci Technol

224

143

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Aloe vera is used for vigor, wellness and medicinal purposes since rigvedic times. Health benefits of aloe vera include its application in wound healing, treating burns, minimizing frost bite damage, protection against skin damage from x-rays, lung cancer, intestinal problems, increasing high density lipoprotein (HDL), reducing low density lipoprotein (LDL), reducing blood sugar in diabetics, fighting acquired immune deficiency syndrome (AIDS), allergies and improving immune system. Phytochemistry of aloe vera gel has revealed the presence of more than 200 bioactive chemicals. Aloe vera gel is extracted from its leaves and appropriate processing techniques are needed for stabilization as well as preparation of the end products. The industries involved in processing of aloe vera need Government surveillance to ensure that the aloe vera products have beneficial bio-active chemicals as per claims of the manufacturers. Regulatory bodies also need to look into the safety and toxicological aspects of aloe vera products for food applications. The claims made for medicinal value of aloe products should be supported by authentic and approved clinical trial data. It is presumptive to mention that nutraceutical claims of aloe products made by the manufacturers are numerous. However, approved clinical evidences are available only for lowering LDL, increasing HDL, decreasing blood glucose level, treating genital herpes and psoriases.

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“…vera is known to cause hypersensitivity reactions in the form of contact dermatitis [7,28] . The A. vera gel preparation (97.5%) used in our study was well tolerated without any side effects.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Anti-Inflammatory Potential of <i>Aloe vera</i> Gel (97.5%) in the Ultraviolet Erythema Test

Reuter

Jocher

Stump

et al. 2008

Skin Pharmacol Physiol

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Background:Aloe vera is a natural product that is frequently used in soothing skin care products such as aftersun lotions. In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo. Methods: 40 volunteers with skin types II and III were included in the randomized, double-blind, placebo-controlled, phase III monocenter study. Test areas on the back were irradiated with the 1.5-fold minimal erythema dose of UVB. Subsequently, the test areas were treated occlusively on 2 subsequent days with A. vera gel (97.5%), the positive controls (0.25% prednicarbate, 1% hydrocortisone in placebo gel and 1% hydrocortisone cream) and a placebo gel. Erythema values were determined photometrically after 24 and 48 h. Results:A. vera gel (97.5%) significantly reduced UV-induced erythema after 48 h, being superior to 1% hydrocortisone in placebo gel. In contrast, 1% hydrocortisone in cream was more efficient than A. vera gel. Conclusions: In this study after 48 h the A. vera gel (97.5%) displayed some anti-inflammatory effects superior to those of 1% hydrocortisone in placebo gel. The A. vera gel tested here might be useful in the topical treatment of inflammatory skin conditions such as UV-induced erythema.

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Hypersensitivity to aloe

Abstract: Hypersensitivity, manifested by generalized nummular eczematous and papular dermatitis, and presumably by contact urticaria, developed in a 47-year-old man after four years of using oral and topical aloe. Patch tests for aloe were positive in this patient.

Cited by 37 publications

References 0 publications

The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf – a preliminary clinical investigation

The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf – a preliminary clinical investigation

Processing, food applications and safety of aloe vera products: a review

Investigation of the Anti-Inflammatory Potential of <i>Aloe vera</i> Gel (97.5%) in the Ultraviolet Erythema Test

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