Hypersensitivity reactions to cephalosporins

Minimal cross-intolerance with nilotinib in patients with chronic myeloid leukemia in chronic or accelerated phase who are intolerant to imatinib

“…For example, cephalosporin and penicillin can cause significant cross-reactivity. 14 In the case of nilotinib and imatinib, however, nonhematologic cross-intolerance leading to discontinuation did not occur. None of the 75 patients with grade 3/4 or persistent grade 2 nonhematologic toxicity during imatinib therapy required a dose reduction or discontinuation of nilotinib because of the same AE, and only 1 patient experienced grade 3/4 toxicity of the same nature (diarrhea).…”

Validation of the cephalosporin intradermal skin test for predicting immediate hypersensitivity: a prospective study with drug challenge

“…Cephalosporins are currently one of the most widely prescribed antibiotics along with penicillins, because of their broad spectrum of activity on both gram‐positive and gram‐negative bacteria . The therapeutic use of cephalosporins has been increasing since the 1990s, and reports of hypersensitivity reactions to cephalosporins are also increasing.…”

Practical management of antibiotic allergy in adults

“…Newer cephalosporins such as cefuroxime, ceftazidime, ceftriaxone are unlikely to be associated with cross-reactivity because of differences in chemical structure and do not appear to pose the same level of risk 39. Nevertheless, immunologist/allergist evaluation is strongly recommended where possible 41. A clinician faced with a patient with possible penicillin allergy has a number of options (figure 2).…”