Hypersensitivity Pneumonitis and Related Conditions in the Work Environment

Zacharisen, Michael C.; Fink, Jordan N.

doi:10.1016/j.iac.2011.07.004

Cited by 33 publications

(23 citation statements)

References 69 publications

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“…The disease is characterized by a lymphocytic alveolitis, noncaseating granulomas and, in some patients, develops into a chronic form which is associated with fibrosis and emphysema [1,3,6–8]. HP is a complex disease with components of Type III (antibody-mediated) and Type IV (cell-mediated) hypersensitivity reactions for which there are limited therapeutic options; the mainstay of treatment is avoidance of the inciting agent and corticosteroids which have limited effects on outcome.…”

Section: Introductionmentioning

confidence: 99%

“…HP is a complex disease with components of Type III (antibody-mediated) and Type IV (cell-mediated) hypersensitivity reactions for which there are limited therapeutic options; the mainstay of treatment is avoidance of the inciting agent and corticosteroids which have limited effects on outcome. The environmental antigens that induce HP include organic dusts, vapors, fungi, bacteria, and molds as well as simple chemical compounds [6,9,10]. Exposure to these airborne antigens may occur in both occupational and residential settings and the different types of HP are frequently named after the occupation or activity that results in exposure to the inciting agent.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

TLR2 Regulates Neutrophil Recruitment and Cytokine Production with Minor Contributions from TLR9 during Hypersensitivity Pneumonitis

Andrews

Abdelsamed

et al. 2013

PLoS ONE

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Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to environmental antigens. The disease results in alveolitis, granuloma formation and may progress to a fibrotic chronic form, which is associated with significant morbidity and mortality. The severity of the disease correlates with a neutrophil rich influx and an IL-17 response. We used the Saccharopolyspora rectivirgula (SR) model of HP to determine whether Toll-like receptors (TLR) 2 and 9 cooperate in neutrophil recruitment and IL-17-associated cytokine production during the development of HP. Stimulation of bone marrow derived macrophages (BMDMs) from C57BL/6, MyD88-/- and TLR2/9-/- mice with SR demonstrate that SR is a strong inducer of neutrophil chemokines and growth factors. The cytokines induced by SR were MyD88-dependent and, of those, most were partially or completely dependent on TLRs 2 and 9. Following in vivo exposure to SR, CXCL2 production and neutrophil recruitment were reduced in TLR2-/- and TLR2/9-/- mice suggesting that the response was largely dependent on TLR2; however the reduction was greatest in the TLR2/9-/- double knockout mice indicating TLR9 may also contribute to the response. There was a reduction in the levels of pro-inflammatory cytokines TNFα and IL-6 as well as CCL3 and CCL4 in the BALF from TLR2/9-/- mice compared to WT and single knockout (SKO) mice exposed one time to SR. The decrease in neutrophil recruitment and TNFα production in the TLR2/9-/- mice was maintained throughout 3 weeks of SR exposures in comparison to WT and SKO mice. Both TLRs 2 and 9 contributed to the Th17 response; there was a decrease in Th17 cells and IL-17 mRNA in the TLR2/9-/- mice in comparison to the WT and SKO mice. Despite the effects on neutrophil recruitment and the IL-17 response, TLR2/9-/- mice developed granuloma formation similarly to WT and SKO mice suggesting that there are additional mediators and pattern recognition receptors involved in the disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TLR2 Regulates Neutrophil Recruitment and Cytokine Production with Minor Contributions from TLR9 during Hypersensitivity Pneumonitis

Andrews

Abdelsamed

et al. 2013

PLoS ONE

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“…Multivariate Hypersensitivity pneumonitis (HP) is a rare and complex interstitial lung disease (ILD) triggered by inhaled antigens, with multiple known causative agents. [1][2][3][4][5][6][7][8][9] Treatment is primarily aimed at identifying and avoiding the implicated antigen. 1,10,11 Identifying the off ending antigen, however, is achieved only in about 40% of cases.…”

Section: Discussionmentioning

confidence: 99%

Lung Transplantation for Hypersensitivity Pneumonitis

Kern

Singer

Koth

et al. 2015

Chest

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“…Members of the class Actinobacteria are predominant among airborne environmental microorganisms and represent an important trigger to human respiratory health. Airborne spores of Saccharopolyspora , Streptomyces , and Thermoactinomyces genera ( Firmicutes ) are responsible for hypersensitivity pneumonitis known as farmer’s or mushroom worker’s lung (Zacharisen and Fink 2011; Xu et al 2002; Moore et al 2004) and other severe health effects (Kagen et al 1981; Lacey and Dutkiewicz 1994). …”

Section: Introductionmentioning

confidence: 99%

An airborne actinobacteria Nocardiopsis alba isolated from bioaerosol of a mushroom compost facility

et al. 2014

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Actinobacteria are widely distributed in many environments and represent the most important trigger to the occupant respiratory health. Health complaints, including hypersensitivity pneumonitis of the workers, were recorded in a mushroom compost facility (MCF). The studies on the airborne bacteria were carried out to find a possible microbiological source of these symptoms. Culture analysis of compost bioaerosols collected in different location of the MCF was performed. An assessment of the indoor microbial exposure revealed bacterial flora of bioaerosol in the mushroom compost facility represented by Bacillus, Geobacillus, Micrococcus, Pseudomonas, Staphylococcus spp., and actinobacterial strain with white aerial mycelium. The thermotolerant actinobacterial strain of the same morphology was repeatedly isolated from many locations in MCF: air, compost sample, and solid surface in production hall. On the base of complex morphological, chemotaxonomic, and phylogenetic characteristics, the isolate has been classified as Nocardiopsis alba. Dominant position of N. alba in microbial environment of the mushroom compost facility may represent an indicator microorganism in compost bioaerosol. The bioavailability of N. alba in mushroom compost facility creates potential risk for the health of workers, and the protection of respiratory tract and/or skin is strongly recommended.

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Hypersensitivity Pneumonitis and Related Conditions in the Work Environment

Cited by 33 publications

References 69 publications

TLR2 Regulates Neutrophil Recruitment and Cytokine Production with Minor Contributions from TLR9 during Hypersensitivity Pneumonitis

TLR2 Regulates Neutrophil Recruitment and Cytokine Production with Minor Contributions from TLR9 during Hypersensitivity Pneumonitis

Lung Transplantation for Hypersensitivity Pneumonitis

An airborne actinobacteria Nocardiopsis alba isolated from bioaerosol of a mushroom compost facility

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