Hypersensitivity pneumonitis among wind musicians – an overlooked disease?

Møller, Janne; Hyldgaard, Charlotte; Kronborg-White, Sissel; Rasmussen, Finn; Bendstrup, Elisabeth

doi:10.1080/20018525.2017.1351268

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…Mycobacterium chelonae was isolated from a bassoon played by a professional musician diagnosed with HP, but molds were also isolated and no NTM or molds were isolated from the BAL from the patient (Moller et al, 2017). Thus, the association may not be causal.…”

Section: Discussionmentioning

confidence: 99%

Host Variability in NTM Disease: Implications for Research Needs

2018

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Non-tuberculous mycobacteria (NTM) are ubiquitous environmental organisms that may cause opportunistic infections in susceptible hosts. Lung infections in immunocompetent persons with structural lung disease are most common, while disseminated disease occurs primarily in immunocompromised individuals. Human disease caused by certain species, such as Mycobacterium avium complex, Mycobacterium abscessus, and Mycobacterium kansasii, is increasing in incidence and varies by geographic distribution. The spectrum of NTM disease varies widely in presentation and clinical outcome, but certain patterns can be organized into clinical phenotypes. Treatment options are limited, lengthy, and often toxic. The purpose of this case-based review is to provide non-clinician scientists with a better understanding of human NTM disease with an aim to stimulate more research and development.

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Section: Discussionmentioning

confidence: 99%

Host Variability in NTM Disease: Implications for Research Needs

2018

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“…These observations are corroborated by a case study, published in 2017, where molds and mycobacteria isolated from wind instruments were associated with 2 cases of HP. 35 The first case, was a 56-year-old woman that played the bassoon. Her respiratory symptoms had disappeared during a summer holiday, where she had not been playing.…”

Section: Resultsmentioning

confidence: 99%

The association between fungi exposure and hypersensitivity pneumonitis: a systematic review

Gomes¹,

Morais

Rufo

2021

Porto Biomedical Journal

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A systematic review of published studies focused on the association between hypersensitivity pneumonitis (HP) and fungi exposure was conducted on PubMed, following PRISMA guidelines for systematic reviews. A total of 14 studies met the inclusion criteria but only 6 of these studies were eligible, as the remaining 8 represented case reports that were separately included for further discussion. HP is an interstitial lung disease (ILD) characterized by a hypersensitization response to inhalable antigens and represents 1.5% to 12% of all ILD in the European population. Several fungi species that populate the indoor environment have been associated with the incidence of HP upon cumulative exposure, with Penicillium spp and Aspergillus spp being the fungi species most frequently associated with the onset of disease. Although some studies have shown that avoiding exposure to causative HP fungi tends to improve patients’ symptoms, other studies were unable to identify the source of sensitization. More microbial exposure studies are needed to properly estimate the risk of HP development in the built environment.

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“…In addition to type 1 allergies, mold can also induce type 3 and 4 hypersensitive reactions, known as hypersensitivity pneumonitis (HP) [36]. These reactions are mediated by immune complexes and T helper 1 cells, respectively [37,38].…”

Section: Mold-induced Hypersensitivitymentioning

confidence: 99%

Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?

Kraft

Buchenauer

Polte

2021

IJMS

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Fungi represent one of the most diverse and abundant eukaryotes on earth. The interplay between mold exposure and the host immune system is still not fully elucidated. Literature research focusing on up-to-date publications is providing a heterogenous picture of evidence and opinions regarding the role of mold and mycotoxins in the development of immune diseases. While the induction of allergic immune responses by molds is generally acknowledged, other direct health effects like the toxic mold syndrome are controversially discussed. However, recent observations indicate a particular importance of mold/mycotoxin exposure in individuals with pre-existing dysregulation of the immune system, due to exacerbation of underlying pathophysiology including allergic and non-allergic chronic inflammatory diseases, autoimmune disorders, and even human immunodeficiency virus (HIV) disease progression. In this review, we focus on the impact of mycotoxins regarding their impact on disease progression in pre-existing immune dysregulation. This is complemented by experimental in vivo and in vitro findings to present cellular and molecular modes of action. Furthermore, we discuss hypothetical mechanisms of action, where evidence is missing since much remains to be discovered.

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Hypersensitivity pneumonitis among wind musicians – an overlooked disease?

Cited by 9 publications

References 8 publications

Host Variability in NTM Disease: Implications for Research Needs

Host Variability in NTM Disease: Implications for Research Needs

The association between fungi exposure and hypersensitivity pneumonitis: a systematic review

Mold, Mycotoxins and a Dysregulated Immune System: A Combination of Concern?

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