Hypersegmented granulocytes and COVID-19 infection

Salib, Christian; Teruya‐Feldstein, Julie

doi:10.1182/blood.2020006483

Cited by 13 publications

(18 citation statements)

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“… 24 Similar inclusions were found by us in one patient’s lymphocytes with a severe stage ( Figure 1H ), showing that they are not specific for myeloid lineage. Alterations of granulocytes can be different in COVID-19; Christian Salib et al showed hypersegmented granulocytes infected patients; 25 in our study, we found that pseudo-Pelger-Huet anomalies were significantly present, especially in severe patients. Similarly, Gina Zini et al reported morphological anomalies of circulating blood cells in COVID-19 patients.…”

Section: Discussionsupporting

confidence: 57%

Simple Peripheral Blood Smear Findings of Covid-19 Patients Provide Information About the Severity of the Disease and the Duration of Hospital Stay.

Berber

Çağaşar

Sarıcı

et al. 2020

Mediterr J Hematol Infect Dis

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Backround Data about the morphological changes of Covid-19 infection in peripheral blood smear are limited and association with clinical severity of the disease are not known yet. We aimed to examine the characteristics of the cells detected in the pathological rate and / or appearance and whether these findings are related to the clinical course by evaluating the peripheral blood smear at the time of diagnosis in Covid-19 patients. Methods Clinical features, laboratory data, peripheral blood smear of fifty patients diagnosed with Covid-19 by PCR was evaluated at diagnosis. Peripheral smear samples of the patients were compared with the age and sex matched 30 healthy controls. Pictures were taken from the paitients’peripheral blood smear. Patients were divided into two groups. Early and advanced stage patient groups were compared in terms of laboratory data and peripheral smear findings. The relationship between the laboratory values of all patients and the duration of hospitalization was analyzed. Results Pseudo pelger-huet, atypical lymphocytes, vacuole monocytes and pycnotic neutrophils rates were high in the patient group. Increased pseudo pelger-huet anomaly, psodo-pelger huet/mature lymphocyte ratio, decreased number of mature lymphocytes, and eosinophils in peripheral blood smear were observed in the advanced stage patients (p <0.05). A negative correlation was observed between the duration of hospitalization and mature lymphocyte, and monocytes with vacuoles rates (p <0.05). Conclusion Peripheral smear is a cheap, easily performed, and rapid test. Increased pseudo-pelger huet anomaly/mature lymphocytes rate is suggesting advanced stage disease, while high initial monocytes with vacuoles and mature lymphocyte rates at the time of diagnosis may be an indicator of shortened duration of hospitalization.

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Section: Discussionsupporting

confidence: 57%

Simple Peripheral Blood Smear Findings of Covid-19 Patients Provide Information About the Severity of the Disease and the Duration of Hospital Stay.

Berber

Çağaşar

Sarıcı

et al. 2020

Mediterr J Hematol Infect Dis

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“…Los neutrófilos en pacientes con enfermedad severa pueden presentar valores absolutos de 11,6 x 10 9 /L (12). La morfología reportada en la línea granulocítica comprende hipergranulación, hiposegmetación e hipercondensación nuclear, así como la posibilidad de hipersegmentación (13,14).…”

Section: Alteración De Los Valores Del Hemogramaunclassified

Alteraciones hematológicas en COVID-19

Palacio

Henao

2020

nova

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El SARS (síndrome respiratorio agudo grave) es el estadio grave de la COVID-19 ocasionado por el SARS-CoV-2, que causa infecciones respiratorias en humanos y cuya transmisión se da principalmente por contacto. El virus ingresa a la célula huésped por la interacción de la proteína S con la enzima convertidora de angiotensina II (ACE2), presente en el tracto respiratorio, así como en monocitos, macrófagos, células endoteliales, corazón y tracto gastrointestinal. El aumento de IFN frena la replicación viral y activa la respuesta inmune adaptativa. Así, las manifestaciones clínicas de la infección se presentan frecuentemente a nivel del tracto respiratorio; sin embargo, también pueden involucrar otros sistemas como el hematopoyético. En el hemograma se observan recuentos celulares alterados, principalmente leucocitos y plaquetas. La linfopenia y neutrofilia se asocian con enfermedad severa y la trombocitopenia se presenta de manera heterogénea en la infección. Entre las complicaciones se encuentra la coagulación intravascular diseminada, producida cuando los monocitos y las células endoteliales son activadas por la liberación de citoquinas; esto genera daño endotelial, con la síntesis del factor tisular, secreción de factor tisular, activación plaquetaria y liberación del factor Von Willebrand, así como una condición hiperfibrinolítica especialmente en estadios tardíos de la infección. Las pruebas de laboratorio como el dímero D, los productos de degradación de la fibrina (PDF), tiempo de protrombina (TP), tiempo de tromboplastina parcial activado (TTPA), entre otras, son fundamentales para el diagnóstico, seguimiento y pronóstico de la enfermedad.

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“…Taking oxidative stress into consideration, granulocytes play a relevant role in viral infections, even COVID-19 [ 76 ]. Neutrophils may represent the most important cell type in this context, since they produce significant superoxide free radicals and H 2 O 2 , constituting an important mechanism in the elimination of pathogens [ 77 ].…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?

Fernandes

Brito

Reis

et al. 2020

Oxidative Medicine and Cellular Longevity

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The phenomenon of oxidative stress, characterized as an imbalance in the production of reactive oxygen species and antioxidant responses, is a well-known inflammatory mechanism and constitutes an important cellular process. The relationship of viral infections, reactive species production, oxidative stress, and the antiviral response is relevant. Therefore, the aim of this review is to report studies showing how reactive oxygen species may positively or negatively affect the pathophysiology of viral infection. We focus on known respiratory viral infections, especially severe acute respiratory syndrome coronaviruses (SARS-CoVs), in an attempt to provide important information on the challenges posed by the current COVID-19 pandemic. Because antiviral therapies for severe acute respiratory syndrome coronaviruses (e.g., SARS-CoV-2) are rare, knowledge about relevant antioxidant compounds and oxidative pathways may be important for understanding viral pathogenesis and identifying possible therapeutic targets.

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Hypersegmented granulocytes and COVID-19 infection

Cited by 13 publications

References 0 publications

Simple Peripheral Blood Smear Findings of Covid-19 Patients Provide Information About the Severity of the Disease and the Duration of Hospital Stay.

Simple Peripheral Blood Smear Findings of Covid-19 Patients Provide Information About the Severity of the Disease and the Duration of Hospital Stay.

Alteraciones hematológicas en COVID-19

SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?

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