Hyperpolarized 3Helium Magnetic Resonance Imaging in Patients Undergoing Surgery for Emphysema

Chronic Obstructive Pulmonary Disease: Safety and Tolerability of Hyperpolarized129Xe MR Imaging in Healthy Volunteers and Patients

“…For the healthy volunteer group, both heart and respiratory rates did increase slightly from baseline to the 1-minute postdose interval, with a gradual return to near mean baseline levels. A similar trend has been reported for 3 He MR imaging and attributed to a likely slight anxiety associated with imaging examination ( 13 ). There was also a trend toward slightly higher heart rate at the 30-and 60-minute time points after the last dose.…”

“…Considerable experience at numerous institutions has proved hyperpolarized 3 He MR imaging to be safe, not only in healthy subjects, but also in subjects with obstructive airfl ow ( 13 ). Unfortunately, dissemination of 3 He MR imaging faces challenges given the constrained supply of 3 He and recent increased 3 He use for homeland security applications, which has driven up costs from approximately $100 per liter to approximately $500 per liter ( 14 ).…”

“…Adverse events recorded for all subjects resolved within 1.6 minutes 6 0.9 without treatment or clinical intervention. The longest lasting adverse event was that of somnolence experienced by the age-matched control subject, and this resolved within 10 minutes as documented Table 3 Summary of Adverse Event Intensity THORACIC IMAGING: Safety and Tolerability of 129 Xe MR Imaging Driehuys et al approach was important to preserve our relatively modest 129 Xe polarization and is identical to the one used to administer hyperpolarized 3 He for many years without adverse consequences ( 13 ). The present study has shown that O 2 saturation after inspiration and breath hold changed, on average, by less than 1% during the 10 minutes of recording after all xenon doses.…”

“…Moreover, each subject received 1 L of 129 Xe, regardless of their lung volume, which likely caused some variability in the alveolar xenon concentrations from subject to subject. While a very detailed panel of vital signs was collected during this study, there was no effort to capture the nadir of O 2 saturation that may have occurred before the fi rst recording at 1 minute after dose ( 13 ). Finally, subjects were only observed for 24 hours.…”