2012
DOI: 10.1016/j.acra.2011.10.007
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Hyperpolarized 3He Magnetic Resonance Functional Imaging Semiautomated Segmentation

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Cited by 176 publications
(202 citation statements)
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“…Eighteen subjects (18 of 60 = 30%) reported normal VDP and 42 (42 of 60 = 70%) subjects reported abnormally elevated VDP. As shown in Figure 1 for three representative subjects, volunteers with normal VDP showed small or no ventilation defects along the periphery of the lung, whereas (16) 27 (14) 28 (17) .86 (1.0) Years quit smoking 19 (15) 13 (12) 21 (15) .06 (1.0) BMI, kg/m 2 29 (4) 29 (5) 30 (4) .5 (1.0) FVC, % pred 97 (13) 100 (10) 95 (14) .18 (1.0) FEV 1 , % pred 104 (13) 106 (12) 102 (14) .28 (1.0) FEV 1 /FVC 80 (6) 80 (6) 80 (6) .78 (1.0) RV/TLC, % pred 103 (15) 104 (12) 103 (16 ADC, apparent diffusion coefficient; BMI, body mass index; BSA, body surface area; DL CO , diffusing capacity for carbon monoxide; FEV 1 , forced expiratory volume in 1 second; FVC, forced vital capacity; LA, mean fifth generation airway lumen area; 6MWD, six-minute walk distance; RA 950 , relative area of the lung parenchyma with attenuation #À950 HU; RV, residual volume; SD, standard deviation; SGRQ, St. Georges Respiratory Questionnaire; TLC, total lung capacity; VDP, ventilation defect percent; WA%, mean fifth generation airway wall area percent.…”
Section: Resultsmentioning
confidence: 99%
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“…Eighteen subjects (18 of 60 = 30%) reported normal VDP and 42 (42 of 60 = 70%) subjects reported abnormally elevated VDP. As shown in Figure 1 for three representative subjects, volunteers with normal VDP showed small or no ventilation defects along the periphery of the lung, whereas (16) 27 (14) 28 (17) .86 (1.0) Years quit smoking 19 (15) 13 (12) 21 (15) .06 (1.0) BMI, kg/m 2 29 (4) 29 (5) 30 (4) .5 (1.0) FVC, % pred 97 (13) 100 (10) 95 (14) .18 (1.0) FEV 1 , % pred 104 (13) 106 (12) 102 (14) .28 (1.0) FEV 1 /FVC 80 (6) 80 (6) 80 (6) .78 (1.0) RV/TLC, % pred 103 (15) 104 (12) 103 (16 ADC, apparent diffusion coefficient; BMI, body mass index; BSA, body surface area; DL CO , diffusing capacity for carbon monoxide; FEV 1 , forced expiratory volume in 1 second; FVC, forced vital capacity; LA, mean fifth generation airway lumen area; 6MWD, six-minute walk distance; RA 950 , relative area of the lung parenchyma with attenuation #À950 HU; RV, residual volume; SD, standard deviation; SGRQ, St. Georges Respiratory Questionnaire; TLC, total lung capacity; VDP, ventilation defect percent; WA%, mean fifth generation airway wall area percent.…”
Section: Resultsmentioning
confidence: 99%
“…Ventilation heterogeneity or regions of ''signal void'' were quantified as 3 He ventilation defect percent (VDP) using semiautomated software generated in MATLAB (Mathworks, Natick, MA) as previously described (15). Lobar VDP was generated by registering the segmented thoracic CT lobe mask from VIDA Pulmonary Workstation 2.0 (VIDA Diagnostics Inc., Coralville, IA) to 3 (15).…”
Section: Image Analysismentioning
confidence: 99%
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“…Ventilation defect percent (VDP) estimates were calculated by one observer using semi-automated segmentation software previously described (43).…”
Section: Image Analysismentioning
confidence: 99%
“…Carotid total plaque volume (TPV) and vessel wall volume (VWV) were measured as previously described (43). 3 He MRI ventilation defect percent (VDP) and apparent diff usion coeffi cients (ADC) were measured using semi-automated segmentation generated using custombuilt software in MATLAB R2007b (Th e Math-works Inc., Natick, Massachusetts, USA) as previously described (44,45). CT volumes were analyzed using Pulmonary Workstation 2.0 (PW2, VIDA Diagnostics Inc., Coralville, Iowa, USA).…”
Section: Image Analysismentioning
confidence: 99%