Hyperpolarized 3He Magnetic Resonance Functional Imaging Semiautomated Segmentation

Kirby, Miranda; Heydarian, Mohammadreza; Svenningsen, Sarah; Wheatley, Andrew; McCormack, David G.; Etemad-Rezai, Roya; Párraga, Grace

doi:10.1016/j.acra.2011.10.007

Cited by 176 publications

(202 citation statements)

References 41 publications

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“…Eighteen subjects (18 of 60 = 30%) reported normal VDP and 42 (42 of 60 = 70%) subjects reported abnormally elevated VDP. As shown in Figure 1 for three representative subjects, volunteers with normal VDP showed small or no ventilation defects along the periphery of the lung, whereas (16) 27 (14) 28 (17) .86 (1.0) Years quit smoking 19 (15) 13 (12) 21 (15) .06 (1.0) BMI, kg/m 2 29 (4) 29 (5) 30 (4) .5 (1.0) FVC, % pred 97 (13) 100 (10) 95 (14) .18 (1.0) FEV 1 , % pred 104 (13) 106 (12) 102 (14) .28 (1.0) FEV 1 /FVC 80 (6) 80 (6) 80 (6) .78 (1.0) RV/TLC, % pred 103 (15) 104 (12) 103 (16 ADC, apparent diffusion coefficient; BMI, body mass index; BSA, body surface area; DL CO , diffusing capacity for carbon monoxide; FEV 1 , forced expiratory volume in 1 second; FVC, forced vital capacity; LA, mean fifth generation airway lumen area; 6MWD, six-minute walk distance; RA 950 , relative area of the lung parenchyma with attenuation #À950 HU; RV, residual volume; SD, standard deviation; SGRQ, St. Georges Respiratory Questionnaire; TLC, total lung capacity; VDP, ventilation defect percent; WA%, mean fifth generation airway wall area percent.…”

Section: Resultsmentioning

confidence: 99%

“…Ventilation heterogeneity or regions of ''signal void'' were quantified as 3 He ventilation defect percent (VDP) using semiautomated software generated in MATLAB (Mathworks, Natick, MA) as previously described (15). Lobar VDP was generated by registering the segmented thoracic CT lobe mask from VIDA Pulmonary Workstation 2.0 (VIDA Diagnostics Inc., Coralville, IA) to 3 (15).…”

Section: Image Analysismentioning

confidence: 99%

“…Lobar VDP was generated by registering the segmented thoracic CT lobe mask from VIDA Pulmonary Workstation 2.0 (VIDA Diagnostics Inc., Coralville, IA) to 3 (15).…”

Section: Image Analysismentioning

confidence: 99%

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Ventilation Heterogeneity in Ex-smokers without Airflow Limitation

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

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Ventilation Heterogeneity in Ex-smokers without Airflow Limitation

et al. 2015

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“…Ventilation defect percent (VDP) estimates were calculated by one observer using semi-automated segmentation software previously described (43).…”

Section: Image Analysismentioning

confidence: 99%

Pulmonary MRI morphometry modeling of airspace enlargement in chronic obstructive pulmonary disease and alpha‐1 antitrypsin deficiency

Ouriadov

Lessard

Sheikh

et al. 2017

Magnetic Resonance in Med

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Purpose: We generated lung morphometry measurements using single-breath diffusion-weighted MRI and three different acinar duct models in healthy participants and patients with emphysema stemming from chronic obstructive lung disease (COPD) and alpha-1 antitrypsin deficiency (AATD). Methods: Single-breath-inhaled 3 He MRI with five diffusion sensitizations (b-value ¼ 0, 1.6, 3.2, 4.8, and 6.4 s/cm 2 ) was used, and signal intensities were fit using a cylindrical and single-compartment acinar-duct model to estimate MRIderived mean linear intercept (L m ) and surface-to-volume ratio (S/V). A stretched exponential model was also developed to estimate the mean airway length and L m . Results: We evaluated 42 participants, including 15 elderly never-smokers (69 6 5 years), 12 ex-smokers without COPD (67 6 11 years), 9 COPD ex-smokers (80 6 6 years), and 6 AATD patients (59 6 6 years). In the never-and ex-smokers, the diffusing capacity of the lung for carbon monoxide (DL CO ) and computed tomography relative area of less than 2950 Hounsfield units (RA 950 ) were normal, but these were abnormal in the COPD and AATD patients, which is reflective of emphysema. Although cylindrical and stretched-exponential-model estimates of L m and S/V were not significantly different, the single-compartment-model estimates were significantly different (P < 0.05) for the never-and ex-smoker subgroups. All models estimated significantly worse L m and S/V in the AATD and COPD subgroups compared with the never-and exsmokers without emphysema. Conclusions: Differences in airspace enlargement may be estimated using L m and S/V, generated using MRI and a stretchedexponential or cylindrical model of the acinar ducts. Magn Reson Med 79:439-448,

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“…Carotid total plaque volume (TPV) and vessel wall volume (VWV) were measured as previously described (43). 3 He MRI ventilation defect percent (VDP) and apparent diff usion coeffi cients (ADC) were measured using semi-automated segmentation generated using custombuilt software in MATLAB R2007b (Th e Math-works Inc., Natick, Massachusetts, USA) as previously described (44,45). CT volumes were analyzed using Pulmonary Workstation 2.0 (PW2, VIDA Diagnostics Inc., Coralville, Iowa, USA).…”

Section: Image Analysismentioning

confidence: 99%

Pulmonary Abnormalities and Carotid Atherosclerosis in Ex-Smokers without Airflow Limitation

Pike

Kirby

Lindenmaier

et al. 2014

COPD: Journal of Chronic Obstructive Pulmonary Disease

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It is well-established that COPD patients have a burden of vascular disease that cannot be fully-explained by smoking history but the mechanistic links between atherosclerosis and pulmonary disease in COPD patients are not well-understood. Moreover, in ex-smokers without symptoms or other evidence of COPD, subclinical pulmonary and vascular disease, although potentially present, has not been described or evaluated. Hence our aim was to use sensitive three-dimensional (3D) pulmonary and carotid imaging to quantify pulmonary airway/parenchyma abnormalities and atherosclerosis in ex-smokers without airfl ow limitation or symptoms consistent with COPD. We evaluated 61 subjects without airfl ow limitation including 34 never-(72 ؎ 6 years) and 27 ex-smokers (73 ؎ 9 years), who provided written informed consent to spirometry, plethysmography,

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Hyperpolarized 3He Magnetic Resonance Functional Imaging Semiautomated Segmentation

Cited by 176 publications

References 41 publications

Ventilation Heterogeneity in Ex-smokers without Airflow Limitation

Ventilation Heterogeneity in Ex-smokers without Airflow Limitation

Pulmonary MRI morphometry modeling of airspace enlargement in chronic obstructive pulmonary disease and alpha‐1 antitrypsin deficiency

Pulmonary Abnormalities and Carotid Atherosclerosis in Ex-Smokers without Airflow Limitation

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