Hyperplasia of the Adrenal Medulla

Drukker, W; Formijne, P.; Schoot, J. B. van der

doi:10.1136/bmj.1.5012.186

Cited by 25 publications

(6 citation statements)

References 2 publications

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“…This was indeed the case in our patient for six months after adrenalectomy. In two cases published in the literature where bilateral adrenalectomies were performed, both patients remained mildly hypertensive 3,5 . Since our patient has had a recurrence of her hypertensive paroxysms, she may be a case of bilateral adrenal involvement.…”

Section: Discussionmentioning

confidence: 65%

“…Biochemical evidence supports the diagnosis of a phaeochromocytoma if collected during an episode. Fifteen cases of adrenal medullary hyperplasia without MEN association have been published in the literature before this case report 2‐10 . Twelve cases have been described as having only unilateral involvement 2,4‐9 and three as having bilateral disease 3,5,10 .…”

Section: Discussionmentioning

confidence: 99%

“…All 12 cases were cured of their paroxysms but two remained mildly hypertensive but were easily controlled with medication 4‐9 . Of the three cases with bilateral adrenal medullary hyperplasia without MEN association, two were cured of their paroxysms but remained mildly hypertensive and easily controlled on low‐dose antihypertensive medication 3,5 . The third patient died of a massive myocardial infarction; bilateral adrenal medullary hyperplasia was found at autopsy 10 …”

Section: Discussionmentioning

confidence: 99%

“…In their case, no associated diseases were described. Unilateral or bilateral adrenal medullary hyperplasia outside the context of a MEN Type 2 syndrome has been described in 14 different cases 3‐10 …”

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confidence: 99%

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Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Bailey

Herle

Giuliano

et al. 1999

Int J Clinical Practice

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SUMMARYA case of unilateral adrenal medullary hyperplasia is presented in a 49‐year‐old caucasian female without multiple endocrine neoplasia association. The patient presented with episodic hypertension and paroxysms suggesting an underlying phaeochromocytoma. Biochemical supported this diagnosis but no discrete tumour was found on preoperative localising studies or at the time of surgery. The patient underwent a unilateral adrenalectomy with confirming adrenal medullary hyperplasia with complete resolution of her symptoms for six months.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Bailey

Herle

Giuliano

et al. 1999

Int J Clinical Practice

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“…The clinical entity of adrenomedullary hyperplasia was shown to exist by Drukker et al (1957), reporting a possible case of adrenomedullary hyperplasia. Then, Montalbano et al (1962) reported a convincing case whose hypertension disappeared after the removal of a diffusely enlarged right adrenal gland that had no tumors.…”

Section: Discussionmentioning

confidence: 99%

A case of Cushing's syndrome associated with possible adrenomedullary hyperplasia.

et al. 1985

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A 57-year-old male, who had been suffered from hypertension and diabetes mellitus for 10 years, was admitted to the hospital because of thirst, lassitude and muscle wasting. On admission, his urinary excretion of 17-OHCS and plasma cortisol levels were elevated without diurnal variations. Plasma ACTH levels were found to be very low with repeated determinations. Dexamethasone suppression test, 2 mg 4 times a day orally for 2 days, showed no changes in plasma cortisol levels and only a mild reduction in urinary 17-OHCS excretion. Estimation of urinary catecholamines showed an increase only in norepinephrine. Abdominal computerized tomography and radionuclide scanning of adrenal glands with 131I-adosterol demonstrated a well-defined adrenal mass in the left side without apparent changes in the right side. 131I-metaiodobenzylguanidine scintigraphy was negative. At surgery, his left adrenal medulla was found to be hypertrophic in addition to the cortical tumor. The left adrenal gland was also removed. After surgery, excretion of urinary catecholamines fell to nearly the normal range and he was discharged without insulin and antihypertensive drugs. Microscopically, the cortical tumor is an adenoma consisting of lipid laden cells and eosinophilic compact cells. Medullary cells were distinctly hyperplastic in appearance and many of the cells were extensively vacuolated, suggesting an active functional status. The present report describes a patient with Cushing's syndrome who showed increased urinary catecholamine excretion due to the possible coexistence of adrenal medullary hyperplasia. As far as we know, this is the first case of Cushing's syndrome with this abnormality.

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Unilateral Adrenal Catecholamine Excess

Bauman¹

1982

Arch Intern Med

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Hyperplasia of the Adrenal Medulla

Abstract: As an incidental observation, it was noted that completely adrenalectomized monkeys given 2-8 mg. of Me-F-COL per day rapidly died showing a syndrome characterized by acute cardiovascular damage and leucocytic infiltrations, especially in the liver and kidney.

Cited by 25 publications

References 2 publications

Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

A case of Cushing's syndrome associated with possible adrenomedullary hyperplasia.

Unilateral Adrenal Catecholamine Excess

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