Hyperparathyroidism Diagnosed Due to Brown Tumors of the Jaw: A Case Report and Literature Review

Brabyn, Philip; Capote, Ana; Belloti, Marko; Zylberberg, Ian

doi:10.1016/j.joms.2017.03.013

Cited by 32 publications

(31 citation statements)

References 10 publications

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“…On radiographic and computed tomography exams, well-defined radiolucent or hypodense image are described, usually not demonstrating cortical disruptions and periosteal reactions or inflammatory signs [ 6 ]. This typical cyst-like radiographic appearance can be replaced by a multiloculated lesion with a “ground-glass opacification” which was found in our case [ 4 ].…”

Section: Discussionmentioning

confidence: 57%

“…The brown tumor also known as osteitis fibrosa cystica or Von Recklinghausen's disease of bone is a reactive nonneoplastic giant cell lesion associated with hyperparathyroidism. Products from microbleeding like hemosiderin assign the brown color to the lesion [ 4 , 5 ]. The lesion is more prevalent in patients older than 50 years and three times more frequent in women [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…When biological disorder guides to brown tumor diagnosis, it is useless. Histologically, the presence of diffuse giant cells is characteristic, but there is no pathognomonic sign [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Brown tumors occur in 4.5% of patients with PHPT and between 1.5% and 1.7% in cases of SHPT [ 5 , 8 ] with an overall prevalence of 0.1% [ 4 , 6 ]. The treatment of brown tumors is the cure of the underlying hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Then, a proper diagnosis could have avoided inadequate excision and teeth extractions. Surgical therapy is required in a second step if the lesion persists or if bone healing is compromised, but only after HPT is controlled [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency

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et al. 2018

Case Reports in Dentistry

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Introduction Brown tumors of hyperparathyroidism are locally destructive bone lesions. They are the late clinical consequence of the disease. They can occur in primary, secondary, and rarely tertiary forms. They affect usually long bones and less frequently those of the maxilla. Case Report Our 45-year-old female patient presented with a mandibular tumor next to the first right lower molar. At first, we have chosen tooth extraction and tumor excision. When the histological report showed the giant cell tumor we suspected a metabolic bone disorder. Biochemical tests screened hyperparathyroidism and severe vitamin D deficiency, and parathyroid scintiscan revealed parathyroid adenoma. Discussion The association of hyperparathyroidism and vitamin D deficiency leads to diagnostic uncertainty. First, secondary hyperparathyroidism can be due vitamin D deficiency. Second, data available show that vitamin D deficiency is more prevalent in patients with primary hyperparathyroidism than in general population. Hyperparathyroidism management is based on correct and precise diagnosis. Furthermore, the resolution of brown tumors depends on the cure of hyperparathyroidism. In fact, bone lesions should regress after biological tests' normalization. Conclusion Clinicians should be aware of such rare and complicated presentation. They must consider the diagnosis of the brown tumor to avoid extensive surgical excision and teeth extractions.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

“…When biological disorder guides to brown tumor diagnosis, it is useless. Histologically, the presence of diffuse giant cells is characteristic, but there is no pathognomonic sign [ 4 ].…”

Section: Discussionmentioning

confidence: 99%