Hyperparathyroidism and Pregnancy

Spingarn, Clifford L.; Geist, Samuel H.

doi:10.1001/jama.1939.02800520013003

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…'Perusing the literature we found reports of 40 pregnant women with HPT (1-2, 4-16, [18][19][20][21][22][23][24][25][27][28][29][30][31], including the patient of this case report. These women went through a minimum of 93 pregnancies while suffering from HPT.…”

Section: Discussionmentioning

confidence: 99%

Hyperparathyroidism and Pregnancy

Pedersen

Permin

1975

Acta Obstet Gynecol Scand

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A 28-year-old gravida III, with a history of two unsuccessful pregnancies, was admitted with hyperemesis gravidarum and was found to be suffering from hyperparathyroidism (HPT). She was treated surgically and was later delivered of a wellformed, premature girl. The literature is reviewed and the histories of 40 females (including the patient of this case report) with a minimum of 93 pregnancies while suffering from HPT shows, that HPT during pregnancy is a serious condition for the fetus as well as for the mother. There was an increased incidence of spontaneous abortion, perinatal death, premature birth and neonatal morbidity. The mothers suffered from increased episodes of renal calculi and hyperemesis gravidarum. The exacerbations nearly always occurred in the first and second trimesters or post partum.

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Section: Discussionmentioning

confidence: 99%

Hyperparathyroidism and Pregnancy

Pedersen

Permin

1975

Acta Obstet Gynecol Scand

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“…Its incidence considerably increases after the fourth decade with a prevalence of 0.15% to 0.36% in the general population (1,2). During pregnancy, PHP is rare and approximately 110 cases have been described between 1930 and 1990 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). It is associated with a high prevalence of neonatal morbidity and mortality.…”

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confidence: 99%

Alterations of calcium and phosphate metabolism in primary hyperparathyroidism during pregnancy

Ammann

Irion

Gast

et al. 1993

Acta Obstet Gynecol Scand

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Primary hyperparathyroidism (PHP) is rare during pregnancy and has been claimed to be associated with significant increase of neonatal morbidity and mortality. Whether the well recognized changes in calcium (Ca) and phosphate (Pi) homeostasis occurring in pregnancy might influence the biochemical expression of PHP is unclear. We evaluated biochemical parameters of calcium and phosphate metabolism in two cases of PHP in pregnancy diagnosed in the third trimester (patient 1) and in the second trimester (patient 2). Both patients displayed increase in protein-adjusted plasma Ca, bone resorption evaluated by the fasting urinary Ca-to-creatinine ratio, renal tubular reabsorption of Ca, urinary cAMP excretion and decrease in renal tubular reabsorption of Pi. These alterations were identical to those found in 12 non-pregnant women with PHP. The biochemical expression of PHP did not change after delivery in patient 1. This patient underwent the excision of a 1 g parathyroid adenoma on the 13th day after delivery, which led to normalization of all biochemical parameters. The lowest plasma Ca of the newborn of patient 1 was 2.02 mM 72 hours after birth. Thus, the results indicate that these two pregnant women with PHP displayed biochemical alterations of calcium and phosphate metabolism similar to those observed in non-pregnant women with primary hyperparathyroidism.

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Hyperparathyroidism and pregnancy

Whalley

1963

American Journal of Obstetrics and Gynecology

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Hyperparathyroidism and Pregnancy

Cited by 8 publications

References 21 publications

Hyperparathyroidism and Pregnancy

Hyperparathyroidism and Pregnancy

Alterations of calcium and phosphate metabolism in primary hyperparathyroidism during pregnancy

Hyperparathyroidism and pregnancy

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