Hyperparathyroidism and Pregnancy

Abstract

A 28-year-old gravida III, with a history of two unsuccessful pregnancies, was admitted with hyperemesis gravidarum and was found to be suffering from hyperparathyroidism (HPT). She was treated surgically and was later delivered of a wellformed, premature girl. The literature is reviewed and the histories of 40 females (including the patient of this case report) with a minimum of 93 pregnancies while suffering from HPT shows, that HPT during pregnancy is a serious condition for the fetus as well as for the mother. There was an increased incidence of spontaneous abortion, perinatal death, premature birth and neonatal morbidity. The mothers suffered from increased episodes of renal calculi and hyperemesis gravidarum. The exacerbations nearly always occurred in the first and second trimesters or post partum.

Hypercalcemia during pregnancy: management and outcomes for mother and child

“…Most outcomes on the fetal consequences of hypercalcemia were described in reports on patients with PHPT. Untreated hypercalcemia was associated with fetal or neonatal complications in the majority of cases [3,36,39,40]. However, these findings are based on early literature of PHPT patients when hypercalcemia was often diagnosed in an advanced stage and more recent literature has shown that, compared to age-matched controls, women with PHPT had no difference in most pregnancy outcomes, including stillbirths [39].…”

Hyperparathyroidism in Pregnancy: A Review of the Literature

“…For this review of the literature, we identified 137 case reports with 269 total cases of hyperparathyroidism in pregnancy with the earliest case report published in 1947. There were 85 cases with a single report and 32 case series with the numbers of cases reported varying from 2 to 28 patients in each case report 1,3,5,10–143 …”