Hyperoxaluria; a risk factor or a consequence of recurrent pyelonephritis?

Stepanova, N.

doi:10.34172/jnp.2021.36

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…cause frequent visits to doctors, lead to a sharp decrease in physical and psycho-emotional activity, leave their mark on the quality of life. In fact, the above category of patients needs long-term medical and social care [11,13,14]. Therefore, detailed information on common diseases with the progressive and disabling course is usually important.…”

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confidence: 99%

Acute cystitis in children: age and regional features in Ukraine

Saidakova

Shulyak

Klys

et al. 2021

Ukr. J. Nephrol. and Dial.

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Abstract. The present study aimed to evaluate the dynamics of the incidence of acute cystitis in Ukrainian children in the regional aspect. Methods. The primary documentation is presented by the data of state and branch statistical reports of the institutions of the Ministry of Health of Ukraine for 2013-2017. There are age periods - children under 14 and 15 - 17 years. The indicators were analyzed for Ukraine as a whole, five of its regions, and the regions that make them up. Results. At stabilization of morbidity of children till 14 years which specific weight reaches 70%, annual growth of sick teenagers (on 28,0% from 2013 to 2017) is noted. Conclusionі. Administrative areas have been identified that require increased attention from health authorities and clinicians to develop appropriate measures.

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confidence: 99%

Acute cystitis in children: age and regional features in Ukraine

Saidakova

Shulyak

Klys

et al. 2021

Ukr. J. Nephrol. and Dial.

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“…Проте із зменшенням діаметра тубуса нефроскопа виникає низка недоліків, зокрема підвищення тиску у збиральній системі нирки та необхідність більшої фрагментації конкрементів для видалення, що збільшує тривалість операції, особливо у пацієнтів з великим кам'яним навантаженням [18][19][20].…”

Section: результати дослідження та їх обговоренняunclassified

Comparative Evaluation of the Choice of the Method of Percutaneous Nephrolithotripsy in Patients with Nephrolithiasis

Andrii

Yaroslav

Yаroslav

et al. 2022

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The objective: to analyze the effectiveness and safety of mini-percutaneous nephrolithotripsy (mPCNL) compared to standard percutaneous nephrolithotripsy (sPCNL) in the treatment of nephrolithiasis. Materials and methods. The study analyzed the results of treatment of 1021 patients with solitary (10–30 mm), coral-like and multiple kidney stones for the period from 2016 to 2022. Patients were divided into two groups: sPCNL (500 patients) and mPCNL (521 patients). The average age of patients in both groups was 44.5±15 years. The results of treatment in both groups were compared with each other according to the following parameters: stone-free rate (SFR), duration of surgery, presence of complications, and length of postoperative hospital stay. Results. Both methods are highly effective in the surgical treatment of nephrolithiasis. At the same time, the duration of the operation in the mPCNL group was longer than in the sPCNL group (81.0±15.5 min vs. 69.1±13.9 min; p<0.001), mCPNL was more often finished with drainageless methods (41.1% vs. 6.8%; p<0.001). The postoperative SFR after mPCNL was generally higher (96.4% vs. 91.8%; p=0.002) both in the treatment of solitary stones (98.5% vs. 97.4%; p>0.05) and in treatment of coral-like (90.1% vs. 77.3%; p<0.05) and multiple nephrolithiasis (89.5% vs. 70.8%; p=0.03). The postoperative hemoglobin decrease was smaller in the mPCNL group (1.1±0.34 g/dL vs. 2.1±0.26 g/dL; p<0.001). The infectious complications frequency and length of postoperative stay in the hospital were less in the mPCNL group than in the sPCNL group – 7.3% vs. 13.2% (p=0.03) and 1.9±0.6 days vs. 4.3± 2.4 days, respectively (p<0.001). Conclusions. Mini-percutaneous nephrolithotripsy (m-PCNL) has been proven to be a safe and effective method of nephrolithiasis treatment. Compared with standard percutaneous nephrolithotripsy (sPCNL), patients after mPCNL have a higher SFR, a lower frequency of postoperative complications and duration of postoperative stay in the hospital. An increase operation time by mPCNL is associated with a decrease in the diameter of the tube.

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“…However, besides the overabundance of ExPEC per se, antibiotics can violate the quantitative and qualitative composition of gut microbiota and promote dysbiosis and the intestinal colonization of antibiotic-resistant bacteria ( Lau et al, 2015 ; Yang et al, 2018; Stepanova, 2021 ). Patients with RUTIs must constantly take antibiotics, including long-term antibiotic prophylaxis ( Fine et al, 2019 ; Issakhanian and Behzadi, 2019 ; Toor et al, 2019 ; Meštrović et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections

Stepanova

2022

Front. Pharmacol.

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A comprehensive understanding of urinary tract infections (UTIs), one of the most common human infections, is required as they are complex and poorly understood diseases. Periurethral and vaginal colonization by rectal flora, with the constant presence of pathogens in the urethra, is the initial step of the recurrent UTIs pathway. Current scientific data describe the genetic, etiological, biological, and behavioral risk factors for recurring UTIs, but they do not include the effect of intestinal barrier function on the disease. Although gut microbiota has been proposed as the main source for UTIs, the cross-talk between intestinal barrier dysfunction and the recurrence of UTIs has not yet been supported by scientific data. In this opinion review, based on published data and the results of our clinical studies, I aimed to outline the possible contribution of intestinal barrier dysfunction to the pathogenesis of recurrent UTIs. I believe that the unanswered questions raised by this review can guide further experimental and controlled studies to clarify the mechanisms underlying the role of intestinal barrier dysfunction in the pathogenesis of recurrent UTIs.

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Hyperoxaluria; a risk factor or a consequence of recurrent pyelonephritis?

Cited by 3 publications

References 16 publications

Acute cystitis in children: age and regional features in Ukraine

Acute cystitis in children: age and regional features in Ukraine

Comparative Evaluation of the Choice of the Method of Percutaneous Nephrolithotripsy in Patients with Nephrolithiasis

How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections

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