Hyperoside Attenuates Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Inhibiting Apoptosis in Rats

Shi, Yaoping; Qiu, Xiaoxia; Dai, Mengjun; Zhang, Xuebin; Jin, Guoxi

doi:10.1016/j.transproceed.2019.04.066

Cited by 27 publications

(16 citation statements)

References 34 publications

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“…t-BHP and H 2 O 2 are typical oxidants, which can directly cause oxidative damage of liver cells (Kucera et al, 2014). In our previous in vitro study, we demonstrated that Hyp was able to protect liver injury (Xing et al, 2015), while others showed the Hyp protective effects in ischemia injury (Shi et al, 2019), heart failure-induced liver fibrosis (Guo et al, 2019), and toxins-induced liver injury (Xie et al, 2016;Zou et al, 2017). Our current study further supports these findings of Hyp antioxidant effects.…”

Section: Discussionsupporting

confidence: 86%

“…Our results suggested that Hyp inhibited PHLPP2 expression, promoted AKT phosphorylation and GSK-3b inactivation to possess the liver protective effects in vitro and in vivo. In fact, Nrf2/AKT/GSK-3b/Fyn and AKT/Nrf2 signaling pathway are involved in the protection of natural products against xenobioticse-induced organ toxicity (Liu et al, 2018a;Liu et al, 2018b;Jin et al, 2019). In this present study, we also found that the AKT/GSK-3b/Nrf2 was involved in the protection of Hyp against oxidative stress in liver cells.…”

Section: Figure 7 |supporting

confidence: 74%

“…Hyperoside (Hyp), isolated from Drosera rotundifolia L., seeds of Cuscuta chinensis Lam., or Hypericum perforatum L. originally showed to possess numerous pharmacological effects, including anti-inflammatory, anti-thrombotic, anti-diabetic, anti-viral, anti-fungal, hepato-protective ( Choi et al, 2011 ), and especially anti-oxidative properties ( Li et al, 2005 ; Park et al, 2016 ). More recently , Hyp exhibits an anti-oxidative activity against a series of diseases or conditions, such as carbon tetrachloride (CCl4)-induced liver injury ( Zou et al, 2017 ), and hepatic and renal ischemia-reperfusion injury ( Shi et al, 2019 ; Wu et al, 2019 ). However, the exact mechanisms involved in Hyp-mediated protection of the oxidative damaged liver are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

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Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3β Signaling Pathway In Vivo and In Vitro

Xing

Cheng

et al. 2020

Front. Pharmacol.

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Hyperoside, isolated from Drosera rotundifolia L., seeds of Cuscuta chinensis Lam., or Hypericum perforatum L., originally showed to possess an antifungal and antibacterial activity, while recently showed the protective effects against oxidative stress-induced liver injury. This study investigated such a protective effect of hyperoside and the underlying molecular mechanisms in vitro and in carbon tetrachloride (CCl4)-injured rat livers. The data showed that hyperoside was able to prevent the oxidative stress-induced liver morphological changes and CCl4-induced rat liver injury. Hyperoside reversed the decrease of superoxidase dismutase (SOD) level and the increase of malondialdehyde (MDA) level in vivo. Moreover, hyperoside regulated the pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 2 (PHLPP2)-protein kinase B (AKT)-glycogen synthase kinase 3b (GSK-3b) signaling pathway in tert-butylhydroquinone (t-BHP)-treated liver cells, e.g., Hyperoside reduced PHLPP2 expression to activate AKT phosphorylation, induce GSK-3b phosphorylation, and then increased nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation, reduced nuclear translocation of phosphorylated Fyn, and promoted heme oxygenase-1 (HO-1) expression in vivo and in vitro. In contrast, siRNA-mediated knockdown of PHLPP2 expression enhanced hyperoside-mediated activation of the AKT-GSK-3b kinase pathway in liver cells. In conclusion, the present study demonstrated that hyperoside could protect against oxidative stress-induced liver injury by regulating the PHLPP2-AKT-GSK-3b signaling pathway in vivo and in vitro.

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Section: Discussionsupporting

confidence: 86%

Section: Figure 7 |supporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3β Signaling Pathway In Vivo and In Vitro

Xing

Cheng

et al. 2020

Front. Pharmacol.

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“…Administration of Hyp significantly inhibited the caspase 3 activities induced by Ni in rat brains. A recent study showed that decreased caspase 3 expression was associated with the treatment of Hyp (Shi et al, 2019). Our present study also suggested that Hyp had a potential antiapoptotic effect on neurons.…”

Section: Discussionsupporting

confidence: 82%

Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside

Deniz¹,

Altun²

2020

Turk J Zool

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“…Although hyperoside has been found as a component of some plants with antimicrobial and antioxidant activity [50,51,52,53,54], its mechanism of antimicrobial action of has not been reported yet. In our work, hyperoside showed the lowest in vitro antioxidant action among the tested compounds; however, this biomolecule has shown antioxidant properties in in vivo [55,56,57] and cell-based models [56,58,59]. The antioxidant activity of hyperoside is also highlighted by its anti-inflammatory effects as shown by several reports [54,60,61,62].…”

Section: Discussionsupporting

confidence: 48%

Bioguided Purification of Active Compounds from Leaves of Anadenanthera colubrina var. cebil (Griseb.) Altschul

et al. 2019

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Anadenanthera colubrina var cebil (Griseb.) Altschul is a medicinal plant found throughout the Brazilian semi-arid area. This work performed a bioguided purification of active substances present in ethyl acetate extract from A. colubrina leaves. The anti-Staphylococcus aureus and antioxidant actions were used as markers of bioactivity. The extract was subjected to flash chromatography resulting in five fractions (F1, F2, F3, F4, and F5). The fractions F2 and F4 presented the highest antimicrobial action, with a dose able to inhibit 50% of bacteria growth (IN50) of 19.53 μg/mL for S. aureus UFPEDA 02; whereas F4 showed higher inhibitory action towards DPPH radical (2,2-diphenyl-1-picryl-hydrazyl-hydrate) [dose able to inhibit 50% of the radical (IC50) = 133 ± 9 μg/mL]. F2 and F4 were then subjected to preparative high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR), resulting in the identification of p-hydroxybenzoic acid and hyperoside as the major compounds in F2 and F4, respectively. Hyperoside and p-hydroxybenzoic acid presented IN50 values of 250 μg/mL and 500 μg/mL against S. aureus UFPEDA 02, respectively. However, the hyperoside had an IN50 of 62.5 μg/mL against S. aureus UFPEDA 705, a clinical isolate with multidrug resistant phenotype. Among the purified compounds, the proanthocyanidins obtained from F2 exhibited the higher antioxidant potentials. Taken together, these results highlight the potential of A. colubrina leaves as an alternative source of biomolecules of interest for the pharmaceutical, food, and cosmetic industries.

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Hyperoside Attenuates Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Inhibiting Apoptosis in Rats

Cited by 27 publications

References 34 publications

Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3β Signaling Pathway In Vivo and In Vitro

Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3β Signaling Pathway In Vivo and In Vitro

Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside

Bioguided Purification of Active Compounds from Leaves of Anadenanthera colubrina var. cebil (Griseb.) Altschul

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