Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF‐κB pathway

Xu, Tan; Wu, Xiao; Zhou, Zhou; Ye, Yu; Yan, Chaoting; Zhuge, Nanshan; Yu, Jinhua

doi:10.1002/2211-5463.12937

Cited by 13 publications

(6 citation statements)

References 51 publications

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“…Bone marrow stromal cells were isolated from two-week-old male Sprague–Dawley rats obtained from the Experimental Animal Centre, Nanjing Medical University, China, as previously described [ 23 ]. All protocols were carried out in accordance with the guidelines of the Animal Experiment Committee of Nanjing Medical University.…”

Section: Methodsmentioning

confidence: 99%

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

Yan

et al. 2020

Stem Cells International

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The regeneration of bone and tooth tissues, and related cellular therapies, has attracted widespread attention. Bone marrow mesenchymal stem cells (BMSCs) are potential candidates for such regeneration. iRoot SP is a premixed bioceramic root canal sealer widely used in clinical settings. However, the effect of iRoot SP on the biological features of BMSCs has not been elucidated. In the present study, we found that 0.2 mg/ml iRoot SP conditioned medium promoted osteo/odontogenic differentiation and enhanced mineralization of BMSCs without affecting the proliferative ability. Mechanistically, the NF-κB and MAPK signaling pathways were activated in SP-treated BMSCs, and differentiation was inhibited when cultured with the specific inhibitor. Taken together, these findings demonstrate that iRoot SP promotes osteo/odontogenic differentiation of BMSCs via the NF-κB and MAPK signaling pathways, which could provide a new theoretical basis for clinical applications of iRoot SP and a new therapeutic target for the regeneration of bone and tooth tissue in the future.

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Section: Methodsmentioning

confidence: 99%

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

Yan

et al. 2020

Stem Cells International

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“…Subsequently, some crucial external parameters could be evaluated including bone volume and mineral density, trabeculae thickness, and cementoenamel junction (CEJ)-alveolar bone crest (ABC) distance (Liu et al 2010). In ligature-induced periodontitis model, some crucial internal parameters relating to cellular substances could be observed, where histological analyses show osteoclast activity (Ihn et al 2018;Qiao et al 2018) and arrangement of collagen fibers (Adhikari et al 2019;Xu et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Ligature-induced Periodontitis in Rats and Mice: A Systematic Review on Therapeutic Targets

Abd. Aziz,

Zainal Ariffin,

Mhd Zukhi

et al. 2023

Compend. Oral Sci.

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Introduction: Periodontitis is currently managed through plague removal, both mechanically and chemically. However, limitation to reach the base of deep pockets often results in incomplete protection from periodontal pathogens. Therefore, new treatment modalities are emerging with the aim of controlling the inflammationassociated surrounding tissue damage. There have been strong evidences of preclinical studies on the mechanisms of protection, which may bring insights into the potential therapeutic target(s). We performed a systematic review to identify the therapeutic target(s) in rodent model of periodontitis. Method: The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), ID: CRD42022355578. We searched PubMed, Scopus, and Wiley databases from 2017 to 2021. This systematic review was conducted in accordance with the PRISMA guidelines and studies were selected based on predefined inclusion criteria. We developed a diagram to show the cellular location of the targets. These targets were summarized based on their effects on the outcome determinants such as inflammatory response and the extend of alveolar bone and/or periodontal attachment loss. Decision matrix analysis was used to identify which target(s) hold the most potential. Result: Eleven studies met the inclusion criteria. Result showed that protection in early and late phases of periodontitis involve targets such as transcription factor, protein and lipid kinases, transmembrane receptor, and extracellular protein. Further analysis showed that transcription factor is the most investigated target with the most reported protective outcomes. Conclusion: Protective targets in periodontitis involve different cellular levels. Transcription factor appears as the most potential therapeutic target in rodent model of periodontitis.

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“…Alleviated LPS-induced inflammation, oxidative stress, and apoptosis by upregulating SIRT1 to activate Wnt/β-catenin and sonic hedgehog pathways. [ 83 ] 26 Rat peritoneal macrophages 100 μM Inhibited NO production via inhibition of expression of iNOS by attenuation of p44/p42 MAPK, p38 MAPK and JNK [ 84 ] 27 Chondrocytes, Male C57BL/6 mice 10, 20, 40 μM; 20 mg/kg Suppression of PI3K/AKT/NF-κB and MAPK pathways Enhanced Nrf2/HO-1 [ 85 ] 28 HK-2 cells 10, 50, 100 μM Activation of miR-499a-5p/NRIP1 signal pathway [ 86 ] 29 Male SD rats, BMSCs 40 μg/mL Activation of NF-κB pathway to proliferation and osteogenic differentiation [ 87 ] 30 Mouse peritoneal macrophages 5 μM Inhibition of TNF-α, IL-6, NO production, NF-κB activation [ 25 ] 31 Antidepressant effect C6 glioblastoma cells 1 μM Reduced β2-adrenergic sensitivity [ 88 ] 32 C6 glioblastoma cells 1 μM Reduction in β2-AR density in plasma membrane and decrease in corresponding downstream signaling [ 89 ] 33 PC12 cells 2.5, 5, 10 μg/mL Decreased Ca 2+ , upregulation of CREB and BNDF through the cAMP-CREB signal pathway [ 90 ] 34 …”

Section: Pharmacologic Effectmentioning

confidence: 99%

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Wang,

Zhang,

Yuan

et al. 2023

JIR

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Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and Crataegus , and also detected in many plant species such as Abelmoschus manihot , Ribes nigrum , Rosa rugosa , Agrostis stolonifera , Apocynum venetum and Nelumbo nucifera . This compound exhibits a multitude of biological functions including anti-inflammatory, antidepressant, antioxidative, vascular protective effects and neuroprotective effects, etc. This review summarizes the quantification, original plant, chemical structure and property, structure–activity relationship, pharmacologic effect, pharmacokinetics, toxicity and clinical application of hyperoside, which will be significant for the exploitation for new drug and full utilization of this compound.

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Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF‐κB pathway

Cited by 13 publications

References 51 publications

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

Ligature-induced Periodontitis in Rats and Mice: A Systematic Review on Therapeutic Targets

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

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