Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

Xu, Sijin; Chen, Shuaipeng; Xia, Wenxin; Sui, Hong; Fu, Xueyan

doi:10.3390/molecules27093009

Cited by 47 publications

(52 citation statements)

References 80 publications

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“…Rutin’s pharmaceutical characteristics are studied best among all quercetin glycosides: this compound promotes mammalian smooth muscle relaxation [ 40 ], and rutin’s antioxidant effect protects hepatic cells [ 41 ], inhibits hemoglobin oxidation [ 42 ], and exerts an anti-inflammatory action [ 43 , 44 ]. Large reviews regularly mention the biological activity and therapeutic features of such quercetin glycosides as quercitrin [ 45 ], isoquercitrin [ 46 ], hyperoside [ 47 ], and reynoutrin [ 48 ]; some authors focus on the pharmacological activity of its methyl-containing derivative, isorhamnetin [ 49 ]. Nonetheless, quercetin derivatives that are less common in plants have attracted much attention.…”

Section: Resultsmentioning

confidence: 99%

LC–HRMS for the Identification of Quercetin and Its Derivatives in Spiraea hypericifolia (Rosaceae) and Anatomical Features of Its Leaves

Петрова

Chernonosov

Koval

et al. 2023

Plants

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Spiraea hypericifolia L. is affiliated with the section Chamaedryon Ser. of the genus Spiraea L. (Rosaceae). Similar to many other Spiraea species, S. hypericifolia most often accumulates flavonols among other flavonoids, in particular quercetin and its derivatives. An ethanol–water extract from the aerial part of S. hypericifolia collected in the vicinity of the Ilyichovo settlement (Krasnoyarsk Krai, Russia) was analyzed by liquid chromatography with high-resolution mass spectrometry. Primary and secondary metabolites were found in the extract; structural interpretation consistent with quercetin and its derivatives was proposed for 10 of them. Major compounds were various glycosides of quercetin containing glucose (four compounds), galactose (one compound), xylose (two compounds), arabinose (one compound), or rutinose (one compound) as a carbohydrate residue. Isorhamnetin and 3-O-methylquercetin-3′-O-β-D-glucopyranoside were identified among methyl-containing compounds. The latter compound and reynoutrin, rhamnetin-3-O-β-D-xylopyranosyl-β-D-glucopyranoside, and quercetin-3-O-(6″-O-malonyl)-β-D-glucoside have not been previously found in S. hypericifolia. Data on the presence of quercetin and its derivatives in the extract of S. hypericifolia expand the understanding of the possible practical use of this plant. In addition, the microscopic features of S. hypericifolia leaves were studied. The diagnostic features of the leaf blade necessary for the authentication of raw materials were revealed: straight-walled epidermis cells, stomata located on both sides of the leaf blade (amphistomatic type), two types of trichomes, and wrinkled cuticula with nodi. The main anatomical diagnostic features of the leaves of S. hypericifolia were determined, which makes it possible to assess the authenticity of the raw material.

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Section: Resultsmentioning

confidence: 99%

LC–HRMS for the Identification of Quercetin and Its Derivatives in Spiraea hypericifolia (Rosaceae) and Anatomical Features of Its Leaves

Петрова

Chernonosov

Koval

et al. 2023

Plants

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“…Among them, further investigation is required to evaluate the role of Hyp as an active constituents of Artemisia capillaris —a well-known herbal plant frequently used for treating liver disease [ 104 ]. In addition, based on above medicinal plants containing Hyp, further studies on efficient and economic extraction methods maximizing the purity and yield are needed [ 14 , 95 ]. Hence, Hyp may be an active compound present in various herbal plants that can be widely applied in clinical settings owing to its hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities.…”

Section: Discussionmentioning

confidence: 99%

“…According to recent studies, a few studies have investigated the safety of Hyp [ 14 , 95 ]. In 40 healthy BALB/c mice, Hyp treatment (5,000 mg/kg, intragastrical route once) did not result in mouse poisoning, death, acute toxicity, or genotoxicity [ 96 ].…”

Section: Safety Of Hyperosidementioning

confidence: 99%

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Jang

2022

Antioxidants

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Hyperoside (Hyp), also known as quercetin-3-O-galactoside or 3-O-β-D-galactopyranosyl, is a well-known flavonol glycoside that is abundant in various fruits, vegetables, and medicinal plants. Hyp has been suggested to exhibit a wide range of biological actions, including cardiovascular, renal, neuroprotective, antifungal, antifibrotic, and anticancer effects. Accumulating evidence supports the pharmacological activities of Hyp in improving liver pathophysiology. Hence, the present literature review aims to summarize preclinical data suggesting the beneficial effects and underlying mechanisms of Hyp. In addition, our study focuses on hepatic antioxidant defense signaling to assess the underlying mechanisms of the biological actions of Hyp that are closely associated with liver diseases. Experimental findings from an up-to-date search showed that Hyp possesses hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities in cellular and animal models related to liver dysfunction by enhancing antioxidant responses. In particular, hepatocellular antioxidant defense via activation of erythroid-related nuclear factor 2 by Hyp chiefly explains how this compound acts as a therapeutic agent in liver diseases. Thus, this review emphasizes the therapeutic potential of Hyp as a strong antioxidative substance that plays a crucial role in the regulation of various liver disorders during their pathogenesis.

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“…Hyperoside (Hyp) is a kind of flavonoid compound extracted from many plants, such as Hypericum perforatum L. Flavonoid compounds have been proven to contribute to the treatment of CVD ( Russo et al, 2019 ; Parmenter et al, 2020 ; Gao et al, 2021 ). Some researchers found that Hyp preconditioning reduced the myocardial infraction area and the apoptotic rate in rats, the mechanism of which was likely to be anti-lipid peroxidation, anti-free radical synthesis, and anti-apoptosis ( Xu et al, 2022 ). Recently, a study revealed the effect of Hyp on H/R-induced cell injury by suppressing Bcl-2-interacting protein 3 (Bnip3) expression ( Xiao et al, 2017 ).…”

Section: Herb Medicines and Their Active Chemical Ingredients In Tcm ...mentioning

confidence: 99%

Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review

et al. 2022

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Ischemic heart disease (IHD) is a high-risk disease in the middle-aged and elderly population. The ischemic heart may be further damaged after reperfusion therapy with percutaneous coronary intervention (PCI) and other methods, namely, myocardial ischemia–reperfusion injury (MIRI), which further affects revascularization and hinders patient rehabilitation. Therefore, the investigation of new therapies against MIRI has drawn great global attention. Within the long history of the prevention and treatment of MIRI, traditional Chinese medicine (TCM) has increasingly been recognized by the scientific community for its multi-component and multi-target effects. These multi-target effects provide a conspicuous advantage to the anti-MIRI of TCM to overcome the shortcomings of single-component drugs, thereby pointing toward a novel avenue for the treatment of MIRI. However, very few reviews have summarized the currently available anti-MIRI of TCM. Therefore, a systematic data mining of TCM for protecting against MIRI will certainly accelerate the processes of drug discovery and help to identify safe candidates with synergistic formulations. The present review aims to describe TCM-based research in MIRI treatment through electronic retrieval of articles, patents, and ethnopharmacology documents. This review reported the progress of research on the active ingredients, efficacy, and underlying mechanism of anti-MIRI in TCM and TCM formulas, provided scientific support to the clinical use of TCM in the treatment of MIRI, and revealed the corresponding clinical significance and development prospects of TCM in treating MIRI.

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Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

Cited by 47 publications

References 80 publications

LC–HRMS for the Identification of Quercetin and Its Derivatives in Spiraea hypericifolia (Rosaceae) and Anatomical Features of Its Leaves

LC–HRMS for the Identification of Quercetin and Its Derivatives in Spiraea hypericifolia (Rosaceae) and Anatomical Features of Its Leaves

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Research progress on effects of traditional Chinese medicine on myocardial ischemia–reperfusion injury: A review

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