Hyperoncotic Dextran and Systemic Aprotinin in Necrotizing Rodent Pancreatitis

Abstract

DEX-70 given 3 h and 4 h after induction of pancreatitis significantly reduced the levels of TAP, limited acinar necrosis, and improved survival rate in acute necrotizing rodent pancreatitis. There was no additional benefit from the combination with aprotinin.

The Enteral Factor in Pancreatic Infection

“…Due to capillary leakage with massive fluid loss from the intra-into the extravascular space, patients with severe AP usually present with extreme hemoconcentration. Isovolemic hemodilution using plasma expanders like dextran or hydroxyethyl starch is a very suitable method for rapidly decreasing hematocrit and improving microcirculation and has been tested with good results in animals and patients with severe AP [42,43].…”

Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis

“…Besides perfusion abnormalities, AP is also characterized by local and systemic inflammatory responses, including leukocyte activation as well as release of free radicals and cytokines [12][13][14] . Many therapeutic agents, such as dextran, heparin, p r o c a i n e, L -a r g i n i n e, a n t i ox i d a n t s, o r c y t o k i n e antagonists, have been tested experimentally and/or clinically to improve pancreatic tissue perfusion during AP, however, no significantly successful result has been achieved [1,4,[15][16][17][18] . Epidural anesthesia (EA) that is used to induce analgesia in the perioperative period might be an interesting treatment of the microcirculatory blood flow abnormalities.…”

Contrast-enhanced computed tomography in acute pancreatitis: does contrast medium worsen its course due to impaired microcirculation?

“…released locally from the inflamed pancreas [40][41][42][43][44][45][46][47]. In a series of experimental studies using a rat model of acute pancreatitis [48][49][50][51], several investigators have provided evidence to suggest that the intravenous contrast media used for imaging of parenchymal enhancement in CECT aggravates the impairment of the pancreatic microcirculation during the early phases of acute pancreatitis.…”