Hypernociception and wound healing after application of cyanoacrylate ester as a tissue adhesive in rats

Dip, Etyene Castro; Luz, Diogo; Castro-Silva, Igor Iuco; Pires, Andrea; Linhares, Alvaro; Granjeiro, José Mauro

doi:10.1016/j.tripleo.2011.08.032

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…We demonstrate that the use of cyanoacrylate tissue adhesive is an effective method for closing the CCA after removal of an occluding suture. Cyanoacrylate tissue adhesive has been shown to elicit significantly less inflammation than silk sutures in rats [8] . No site reactions have been observed in animals undergoing MCAO with complete reperfusion as described in this manuscript and consistent and significant infarction and recovery have been observed.…”

Section: Additional Informationmentioning

confidence: 99%

Transient middle cerebral artery occlusion with complete reperfusion in spontaneously hypertensive rats

Hill

Nemoto

2014

MethodsX

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Middle cerebral artery occlusion (MCAO) by the intraluminal suture method is widely used to model ischemic stroke in rats. Current methods include transection or ligation of the external carotid or common carotid artery and thus result in partial restoration of perfusion after transient MCAO. Since incomplete reperfusion may influence recovery and thus confound studies of the impact of neuroprotective compounds and therapies on outcomes after stroke, we have devised a novel method to induce transient MCAO with complete reperfusion. Advantages of the method include: MCAO is achieved through insertion of an intraluminal suture into the internal carotid artery through the common carotid artery.At the end of the occlusion period, the suture is withdrawn and the incision in the common carotid artery is closed with cyanoacrylate tissue adhesive and complete reperfusion is established.No residual subcutaneous sutures remain during recovery.Vasculature is restored to the preoperative state.

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Section: Additional Informationmentioning

confidence: 99%

Transient middle cerebral artery occlusion with complete reperfusion in spontaneously hypertensive rats

Hill

Nemoto

2014

MethodsX

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“…Los organismos Gram negativos serían relativamente poco afectados debido a su membrana de polisacáridos, que aísla la célula de la pared (35) . Además, los ACA ofrecerían una barrera para los microorganismos en el sitio de la incisión, aislando los márgenes de la herida de la saliva y placa bacteriana (17,28,39) .…”

Section: Efecto Antimicrobianounclassified

Adhesivos de cianoacrilato en cirugía oral y maxilofacial

Vargas

Foncea

Campolo

2017

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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RESUMENLos adhesivos de cianoacrilatos (ACA) son materiales sintéticos con propiedades adhesivas. Al ser aplicados en los tejidos polimerizan uniéndose con el tejido subyacente. Desde la década de los 70' se han explorado sus aplicaciones quirúrgicas para el cierre de heridas y fístulas, control de sangrado y fijación de injertos, entre otros, siendo su uso como alternativa para el cierre de heridas en piel y mucosas uno de los más estudiados. Los ACA presentan un limitado grado de absorción, sin evidencia de efectos tóxicos sistémicos. Tienen la ventaja de ser aplicados de forma rápida, indolora, con efecto antibacteriano y hemostático según los reportes de la literatura, pero presentan una reducida fuerza de tensión. El objetivo de esta revisión de la literatura es describir los usos y aplicaciones de los ACA, con enfoque en la cirugía oral y maxilofacial, evaluando de forma crítica sus aplicaciones. PALABRAS CLAVECianoacrilatos, suturas, cierre de heridas, cirugía oral.Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 10(2); 107-110, 2017. ABSTRACTThe cyanoacrylate adhesives (ACA) are synthetic materials with adhesive properties. When is applied in tissues, it polymerizes and bonds with the underlying tissue. Since the 70s' have been explored their surgical applications for closing wounds, fistulas, bleeding control, and graft fixation, among others. Its use as an alternative for closing wounds in skin and mucous is one of the most studied. The ACA have a limited absorption degree, with no evidence of systemic toxic effects. They have the advantage of being applied quickly, painlessly, with antibacterial effect and hemostatic according to the report of literature, but with reduced tensile strength. The objective of this literature review is to describe the use and applications of ACA, with focus on oral and maxillofacial surgery, with a critically evaluation of their applications.

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Hypernociception and wound healing after application of cyanoacrylate ester as a tissue adhesive in rats

Cited by 2 publications

References 35 publications

Transient middle cerebral artery occlusion with complete reperfusion in spontaneously hypertensive rats

Transient middle cerebral artery occlusion with complete reperfusion in spontaneously hypertensive rats

Adhesivos de cianoacrilato en cirugía oral y maxilofacial

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