Hypernephroma with Erythrocythemia

Erythropoietin in Human Plasma in Various Pathological Disorders

“…This increased activity is probably produced by the kidney tissue in these conditions and is responsible for the polycythemia (17). Other investigators (13,15) have found extracts of tumor cells and fluid from cysts of the kidney to be rich in erythropoietin. These findings may suggest that, in some instances, kidney tissue is capable of producing more erythropoietin than is normally needed.…”

“…8, 12, 14, 24) and this has been interpreted as indi cating deficient erythropoietin production by the diseased kidneys. On the other hand high erythropoietin activity has been found in cases of renal tumor, polycystic kidney and hydronephrosis with polycythemia (4,8,12,14,15,17,24). This increased activity is probably produced by the kidney tissue in these conditions and is responsible for the polycythemia (17).…”

Hormones and the Kidney: Possible Therapeutic Role of Testosterone in a Patient with Regression of Metastases from Renal Adenocarcinoma

“…Thus removal of a renal tumour may bring about remission of polycythaemia which recurs with the appearance of metastases. Hewlett et al (1960) have found increased amounts of erythropoietin in extracts of renal adenocarcinoma from polycythaemic patients. As Riches (1963) points out, some renal tumours resemble those of the thyroid, parathyroid, and suprarenals in the ability of both the primary tumour and its metastases to produce a specific hormonal effect.…”

Endocrine Dysfunction in Malignant Disease

“…(Table 1). Polycythaemia with renal carcinoma: In a number of instances (Lange & Gallagher 1962, Penington 1962 increase in erythropoietin in plasma has been demonstrated in patients with erythrocytosis associated with renal carcinoma, and erythropoietin has been recovered from the tumour (Hewlett et al 1960, Gurney 1962, Penington 1962 …”