Hormones and the Kidney: Possible Therapeutic Role of Testosterone in a Patient with Regression of Metastases from Renal Adenocarcinoma

Bloom, H. J. G.; Wallace, D. M. A.

doi:10.1136/bmj.2.5407.474

Cited by 44 publications

(8 citation statements)

References 20 publications

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“…However, these changes, like those seen in breast cancer, may have an endocrine basis. Thus, low levels of androsterone occur in carcinoma of the prostate (Marmorston, Geller, and Weiner, 1969) and, whilst human metastatic renal carcinomas sometimes respond to treatment with androgens (Bloom and Wallace, 1964), in the male golden hamster renal tumours can be produced experimentally by oestrogen administration (Kirkman, 1959).…”

Section: Other Cancersmentioning

confidence: 99%

Aspects of tryptophan metabolism in health and disease: a review.

Rose¹

1972

J Clin Pathol

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In recent years, considerable interest has been developed in the effect of various diseases upon the metabolic pathway by which L-tryptophan is converted to nicotinic acid derivatives. As the list of diseases associated with abnormal tryptophan metabolism has grown, there has been mounting scepticism abc;ut the specificity and clinical significance of many of the observed changes. The aim of this article is to review some of the more recent developments which have taken place in the study of tryptophan metabolism in man, and to show that many of the reported abnormalities may have as their origin the influence of hormonal and nutritional factors upon the metabolic pathway. Recognition of these factors should help to distinguish between non-specific changes brought about by the metabolic response to the 'stress' of any severe illness, and abnormalities of tryptophan metabolism that are of pathological or clinical significance.Clinical research into tryptophan metabolism in man has been largely concerned with the levels of intermediate metabolites that are present in urine collected after the patient has received an oral dose of L-tryptophan. The techniques involved have been discussed by Price, Brown, and Yess (1965), and by Musajo and Benassi (1964), who also reviewed the published results obtained in a variety of diseases. Biochemistry of Tryptophan Metabolism and the Effect of HormonesThe steps involved in the biosynthesis of nicotinic acid and 5-hydroxytryptamine from L-tryptophan are summarized in Figure 1. Some of these enzymatic reactions require pyridoxal 5-phosphate, the coenzyme derived from the various forms of vitamin B6, as a cofactor. Impaired function of this coenzyme results in an elevated urinary excretion ofkynurenine, 3-hydroxykynurenine, and xanthurenic acid, apparently because the kynureninase which is responsible for the conversion of 3-hydroxykynurenine

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Section: Other Cancersmentioning

confidence: 99%

Aspects of tryptophan metabolism in health and disease: a review.

Rose¹

1972

J Clin Pathol

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“…Thirdly, the cytoplasmic ribosonie profile of the estrogen-induced kidney tumor is identical to that of human renal cell carcinoma, in contrast to the ribosome distribution of virus-induced tumors of kidney and other tissues (9). Fourthly, the inhibition of this experimental tumor by progesterone compounds was the basis for hornional treatment of human metastatic renal carcinoma proposed by Bloom and Wallace (1). There was objective palliation in a number of patients treated with natural or synthetic progesterones.…”

Section: Discussionmentioning

confidence: 99%

The response of the stilbestrol‐induced renal tumor to chemotherapeutic agents

deKernion

Resnick

Persky

1973

Journal of Surgical Oncology

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The inhibition of growth of the stilbestrol‐induced hamster kidney tumor by various chemotherapeutic agents was studied in vivo. 5‐Fluorouracil significantly retarded tumor growth and prolonged survival of the treated animals. The antibiotics mithramycin and dactinomycin markedly inhibited the tumor but did not prolong survival. The absence of drug toxicity in the doses used indicated that a more pronounced effect might have been obtained by retreatment at regular intervals. Cyclophosphamide at standard dosage levels did not influence tumor growth rate. The effect of vinblastine could not be properly assessed because of severe drug toxicity.

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“…tained growth and survival and acquires autonomy after serial grafting. This further emphasizes the hormone dependent nature of the tumor (Bloom and Wallace, 1964).…”

mentioning

confidence: 80%

Experimental aspects of renal tumors

Grabstald

1973

Journal of Surgical Oncology

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Spontaneously observed and exogenously induced renal tumors in mice and rats have been described. Occasionally occurring tumors in other species have been reviewed. The relationships between the spontaneously observed and induced tumors and endocrine factors are reviewed. Practical applications for the use of induced tumors as screening techniques for chemotherapy of advanced renal cancer in man are discussed. Limitations in the present models are apparent. Both hormonal and nonhormonal environments can effect relative growth rates in several species of the induced tumors. Common metabolic pathways in several of the alkylating agents for the inductions of renal tumors are described. The virus relationships to frog tumors have been appreciated for some time and have becn further studied. Present clinical problems and controversies, however, remain. Important areas for further study of these models can provide helpful clinical information and have becn discussed.

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Hormones and the Kidney: Possible Therapeutic Role of Testosterone in a Patient with Regression of Metastases from Renal Adenocarcinoma

Cited by 44 publications

References 20 publications

Aspects of tryptophan metabolism in health and disease: a review.

Aspects of tryptophan metabolism in health and disease: a review.

The response of the stilbestrol‐induced renal tumor to chemotherapeutic agents

Experimental aspects of renal tumors

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