Hypermobility syndrome in 105 women with pure urinary stress incontinence and in 105 controls

Karan, Ayşe; Işıkoğlu, Mete; Aksac, Buket; Attar, Erkut; Eskiyurt, Nurten; Yalçın, Önay

doi:10.1007/s00404-002-0429-x

Cited by 13 publications

(9 citation statements)

References 13 publications

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“…Most studies in literature [10,11] have attempted to identify the prevalence of BJHS in women with urinary or anal incontinence, whereas our study attempts the reverse, i.e., to identify the prevalence of urinary and fecal incontinence in women already known to have BJHS. There have been several studies, which have assessed the prevalence of urinary incontinence and pelvic organ prolapse in more severe connective tissue disorders such as Marfan's syndrome and Ehlers-Danlos syndrome [12][13][14].…”

Section: Discussionmentioning

confidence: 89%

Prevalence of incontinence in women with benign joint hypermobility syndrome

Arunkalaivanan

Situnayake

2006

Int Urogynecol J

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The objective of this study was to determine whether the prevalence of urinary and anal incontinence in women with benign joint hypermobility syndrome (BJHS) was more than in a control group without this condition. The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) and the Manchester Health Questionnaire were sent to 30 patients with benign joint hypermobility syndrome and 30 healthy women without this condition and results were compared. It was found out that the prevalence of urinary incontinence in the study group we surveyed was 18/30 and in the control group was 9/30 (60 vs 30%; p=0.037). Twenty-three percent (7/30) of the women with BJHS had a problem with anal incontinence but none of the controls had problems with anal incontinence (23 vs 0%; p=0.01). Therefore, the prevalence of both urinary and anal incontinence appears to be significantly higher in women with BJHS when compared to women without this condition.

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Section: Discussionmentioning

confidence: 89%

Prevalence of incontinence in women with benign joint hypermobility syndrome

Arunkalaivanan

Situnayake

2006

Int Urogynecol J

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“…In fact, the scarcity of descriptive manifestations of JHS/EDS-HT in the medical literature lays on the actual lack of shared knowledge and general unawareness of the practitioners on the multifaceted manifestations of JHS/EDS-HT. The conundrum is further complicated by the increasing number of studies highlighting (generalized) JHM as a possible predisposing factor and/or noncasually associated features for a series of extra-articular disorders (Table 4) [38–64]. At the moment, whether these complaints belong to the wider picture of the JHS/EDS-HT or rather represent nonsyndromic associations needs further investigations.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Clinical manifestations mainly include urinary stress incontinence [64], uterine prolapse, and faecal incontinence [50]. Although prolapses may occur in the nullipara [141], they are most often facilitated by episiotomy and vaginal tears [92].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Castori¹

2012

ISRN Dermatology

176

239

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Ehlers-Danlos syndrome, hypermobility type, constituting a phenotypic continuum with or, perhaps, corresponding to the joint hypermobility syndrome (JHS/EDS-HT), is likely the most common, though the least recognized, heritable connective tissue disorder. Known for decades as a hereditary condition with predominant rheumatologic manifestations, it is now emerging as a multisystemic disorder with widespread manifestations. Nevertheless, the practitioners' awareness of this condition is generally poor and most patients await years or, perhaps, decades before reaching the correct diagnosis. Among the various sites of disease manifestations, skin and mucosae represent a neglected organ where the dermatologist can easily spot diagnostic clues, which consistently integrate joint hypermobility and other orthopedic/neurologic manifestations at physical examination. In this paper, actual knowledge on JHS/EDS-HT is summarized in various sections. Particular attention has been posed on overlooked manifestations, including cutaneous, mucosal, and oropharyngeal features, and early diagnosis techniques, as a major point of interest for the practicing dermatologist. Actual research progresses on JH/EDS-HT envisage an unexpected link between heritable dysfunctions of the connective tissue and a wide range of functional somatic syndromes, most of them commonly diagnosed in the office of various specialists, comprising dermatologists.

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“…The failure to replicate this association in a large sample might reflect either to differences in sampled populations, or differences in diagnostic criteria. Despite the distinction between JHM and BJHS, some previous studies have erroneously claimed to have examined associations with BJHS , despite using diagnostic criteria that only identify JHM. This lack of clarity may also be responsible for a failure to replicate previously reported associations.…”

Section: Discussionmentioning

confidence: 99%

“…Since the initial report of an association between JHM and POP in 1982 , the relationship has been consistently replicated in various populations using either the clinical Beighton criteria or the validated five‐item Hakim questionnaire , which are broadly comparable . Several studies have also considered an association with SUI, but have had conflicting results (Table ) . Pathophysiologically JHM could also be related to urinary storage symptoms, as JHM syndrome involves various autonomic nervous system‐related symptoms, associated with adrenoceptor hyper‐responsiveness .…”

Section: Introductionmentioning

confidence: 99%

Lack of association of joint hypermobility with urinary incontinence subtypes and pelvic organ prolapse

et al. 2014

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ObjectiveTo test the hypothesis that joint hypermobility (JHM) is associated with specific urinary incontinence (UI) subtypes and uterovaginal prolapse. Patients and MethodsIn all, 270 women scheduled to undergo urodynamic investigations were invited to self-complete a validated five-item JHM questionnaire. Women underwent history taking, symptoms assessing via the King's Health Questionnaire and clinical examination using the Pelvic Organ Prolapse Quantification system. Associations between JHM and pelvic floor disorders in univariate and multivariate ordinal regression were reported using odds ratios (ORs) and 95% confidence intervals (CIs). ResultsThe prevalence of JHM was 31.1%. JHM had a negative association with age (OR 0.98/year, P = 0.04). There was no association between JHM and either urodynamic (P = 0.41), or symptomatic stress UI (P = 0.48). Nor was there association with detrusor overactivity or symptomatic urgency UI. Multivariate ordinal regression of JHM with maximum prolapse stage, adjusting for age, showed a significant relationship (OR 1.26/stage, 95% CI 1.06-1.46, P < 0.05). ConclusionAlthough JHM is highly prevalent amongst women with lower urinary tract symptoms (LUTS), there is no strong association of JHM with any UI subtype. There is a trend towards higher prolapse staging in women with JHM, which becomes significant only after adjustment for the confounding negative association between age and JHM.

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Hypermobility syndrome in 105 women with pure urinary stress incontinence and in 105 controls

Cited by 13 publications

References 13 publications

Prevalence of incontinence in women with benign joint hypermobility syndrome

Prevalence of incontinence in women with benign joint hypermobility syndrome

Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Lack of association of joint hypermobility with urinary incontinence subtypes and pelvic organ prolapse

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