Lack of association of joint hypermobility with urinary incontinence subtypes and pelvic organ prolapse

Derpapas, Alex; Cartwright, Rufus; Upadhyaya, Purnima; Bhide, Alka; Digesu, Alex; Khullar, Vik

doi:10.1111/bju.12823

Cited by 10 publications

(8 citation statements)

References 27 publications

(40 reference statements)

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“…Findings on UI were mixed, with 4 of 18 studies finding no association between either EDS or HSD and UI. Among the 14 studies reporting a positive correlation for EDS or HSD and UI, rates between 68% and 84% were reported for adult women .…”

Section: Resultsmentioning

confidence: 99%

Urogenital and pelvic complications in the Ehlers‐Danlos syndromes and associated hypermobility spectrum disorders: A scoping review

2019

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The Ehlers-Danlos syndromes (EDS) and associated hypermobility spectrum disorders (HSD) are a heterogenous group of connective tissue disorders associated with significant morbidity. The urogenital aspects of these disorders are understudied and there is little guidance on the prevalence, types, or outcomes of urogenital complications in EDS/HSD. Our objective was to perform a scoping review to characterize and synthesize the literature reporting urogenital and pelvic complications in EDS/HSD patients. We performed a systematic search of three databases (Medline, CINAHL, Embase) to January 2019. English language, full-text articles reporting on urogenital or pelvic complications in EDS/HSD were included. A total of 105 studies were included (62 case reports/series, 43 observational) involving patients with hypermobile (23%), vascular (20%), classical (12%) EDS, and HSD (24%). Some studies looked at multiple subtypes (11%) or did not report subtype (33%). Reported complications included urinary (41%), gynecological (36%), obstetrical (25%), renal (9%), and men's health problems (7%), with some studies reporting on multiple areas. Urinary and gynecological complications were most prevalent in patients with HSD, while a broad range of complications were reported in EDS. While further research is required, results suggest a higher index of suspicion for urogenital problems is probably warranted in this population.

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Section: Resultsmentioning

confidence: 99%

Urogenital and pelvic complications in the Ehlers‐Danlos syndromes and associated hypermobility spectrum disorders: A scoping review

2019

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“…However, another recent study [Derpapas et al, ] reported a lack of strong association of JH with UI or POP. The study involved 270 women scheduled to undergo urodynamic investigations.…”

Section: Clinical Descriptionmentioning

confidence: 99%

Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history

Tinkle

Castori²,

Berglund

et al. 2017

American J of Med Genetics Pt C

357

348

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The hypermobile type of Ehlers-Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue. It has been described largely in those with musculoskeletal complaints including joint hypermobility, joint subluxations/dislocations, as well as skin and soft tissue manifestations. Many patients report activity-related pain and some go on to have daily pain. Two undifferentiated syndromes have been used to describe these manifestations-joint hypermobility syndrome and hEDS. Both are clinical diagnoses in the absence of other causation. Current medical literature further complicates differentiation and describes multiple associated symptoms and disorders. The current EDS nosology combines these two entities into the hypermobile type of EDS. Herein, we review and summarize the literature as a better clinical description of this type of connective tissue disorder.

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“…Foram avaliadas 270 mulheres e a prevalência para SHA foi de 31,1% (n=84), sendo que os sintomas urinários relatados não apresentaram diferença significativa entre as mulheres com SHA e nem entre as mulheres com SHA e sem SHA. Contudo, a análise da SHA mostra uma tendência para desenvolvimento de POP, que só se tornou significativa após ajuste para a associação negativa apresentada entre a idade e a SHA (4) . Com a finalidade de avaliar a associação entre o POP, distúrbios relacionados com o colágeno e a prevalência de POP nos membros da família, dividiram mulheres em 2 grupos (grupo POP = 110 e grupo controle = 100) para realizar análise.…”

Section: Resultsunclassified

“…O sexo feminino, idade avançada, menopausa e predisposição genética são os principais fatores de risco, podendo incluir ainda a obesidade, gravidez e paridade, ressaltando que os mecanismos relacionados à "falha" do diafragma da pelve ainda não são totalmente compreendidos (12) . Geralmente a SHA se manifesta na infância ou no início da idade adulta, podendo ser um marcador precoce de risco (4) e resultar em alterações do diafragma da pelve em mulheres (20) . Além da identificação dos principais fatores de relação das disfunções do diafragma da pelve com a SHA, o presente estudo identificou a ausência de pesquisas que divulguem sugestões de prevenção.…”

Section: Resultsunclassified

“…Em meio a uma carência literária na genética molecular de IU e POP, despertou-se maior empenho sobre polimorfismos de outro tipo de colágeno I α1 (COL1A1) ou colágeno tipo III α1 (COL3A1). Em diversas populações, variantes comuns nesses genes estavam associados com um aumento dobrado da probabilidade de IU de esforço ou POP, indicando uma plausível causa associada para os distúrbios do diafragma da pelve e hipermobilidade articular (4) . Esta pesquisa buscou atualizar os conhecimentos em relação à associação entre a hipermobilidade articular e as disfunções do diafragma da pelve na população comum.…”

Section: Introductionunclassified

See 1 more Smart Citation

Síndrome De Hipermobilidade Articular Nos Pacientes Com Disfunções Do Diafragma Da Pelve: Revisão De Literatura

Leal

Cavenaghi

Carvalho

2016

ACS

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Con lito de interesses:Não Contribuição dos autores: TTL delineamento do estudo, elaboração e redação do manuscrito. SC orientação e delineamento do estudo. LHC orientação do projeto. Abstract Introduction: Joint hypermobility is the ability to perform joint movements with greater amplitude than normal. We use the term "hypermobility syndrome joint" when there is a combination of extra-skeletal and musculoskeletal signs and symptoms that include a larger number of detaching disorders, including pelvic dysfunction. Pelvic floor dysfunction is a broad term that encompasses urinary incontinence and prolapse of pelvic organs considered greatly prevalent. Objective: Update knowledge of the association between joint hypermobility and dysfunction of the pelvic floor in the common population. Patients and Methods: English and Portuguese articles were selected published between 2010 and 2015 in the electronic databases PubMed, LILACS, and SciELO. Results: The structure of this study was based on references that present significant aspects related to the demand of our research. It comprises 11 studies showing significance in the results towards the existence of the relationship between joint hypermobility and changes in the pelvic floor. Conclusion: It is believed that existing alterations in the collagen composition can be the main cause of the relationship between Articular hypermobility and dysfunction of the pelvic floor. In general, the articles examined in this update tend to support this relationship. However, future implications of this new knowledge for better practice should be considered. Contato para correspondência: Talita Teixeira LealDescriptors: Joint Instability; Pelvic Floor; Collagen.

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Lack of association of joint hypermobility with urinary incontinence subtypes and pelvic organ prolapse

Cited by 10 publications

References 27 publications

Urogenital and pelvic complications in the Ehlers‐Danlos syndromes and associated hypermobility spectrum disorders: A scoping review

Urogenital and pelvic complications in the Ehlers‐Danlos syndromes and associated hypermobility spectrum disorders: A scoping review

Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history

Síndrome De Hipermobilidade Articular Nos Pacientes Com Disfunções Do Diafragma Da Pelve: Revisão De Literatura

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