Hypermethylation and low transcription of TLR2 gene in chronic periodontitis

Amormino, Simone Angélica de Faria; Arão, Telma Cristina; Saraiva, Adriana Machado; Gomez, Ricardo Santiago; Dutra, Walderez Ornelas; Costa, José Eustáquio da; Silva, Jeane de Fátima Correia; Moreira, Paula Rocha

doi:10.1016/j.humimm.2013.04.037

Cited by 51 publications

(56 citation statements)

References 44 publications

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“…The TLR4 gene promoter was unmethylated in most samples in all groups, 42 whereas the TLR2 promoter was both methylated and unmethylated in most samples. A hypermethylation and a subsequent low transcription of TLR2 in periodontitis tissues was reported 43 . Interestingly, a positive correlation was found between TLR2 methylation and periodontal probing depth.…”

Section: Epigeneticsmentioning

confidence: 95%

“…In addition to methylation level of cytokines, a number of other genes related to inflammation have been analyzed in periodontitis 42‐45 . The DNA methylation pattern in the Toll‐like receptor 2 ( TLR2 ) and TLR4 genes was evaluated in gingival tissue samples 42 .…”

Section: Epigeneticsmentioning

confidence: 99%

“…32 Epigenetic mechanisms may also explain why some patients may not respond to treatment and why some individuals are more susceptible to periodontitis. 32 Studies on epigenetic mechanisms in relation to periodontitis [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] are presented in Table 1.…”

Section: Epigeneticsmentioning

confidence: 99%

See 2 more Smart Citations

Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

Larsson

Castilho

Giannobile

2015

Journal of Periodontology

112

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The immune response to oral bacteria and the subsequent activation of inflammatory signaling is not only dependent on genetic factors. The importance of so-called epigenetic mechanisms presents additional regulatory pathways of genes involved in maintaining chronic inflammation, including gingivitis and periodontitis. The term epigenetics relates to changes in gene expression that are not encoded in the DNA sequence itself and include chemical alterations of DNA and its associated proteins. These changes lead to remodeling of the chromatin and subsequent activation or inactivation of a gene. Epigenetic mechanisms have been found to contribute to disease, including cancer and autoimmune or inflammatory diseases. In this state-of-the art review, the authors provide the latest findings on the involvement of epigenetic modifications in the development of periodontal disease and present emerging therapeutic strategies aimed at epigenetic targets (epidrugs) associated with the disruption of tissue homeostasis and the development of periodontitis.

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Section: Epigeneticsmentioning

confidence: 95%

Section: Epigeneticsmentioning

confidence: 99%

See 1 more Smart Citation

Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

Larsson

Castilho

Giannobile

2015

Journal of Periodontology

112

View full text Add to dashboard Cite

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“…Hypermethylation of TLR2 [36], TNFα [37], E-cadherin [38] and COX-2 [39], and hypomethylation of IFN-γ [40] were detected in chronic periodontitis. In patients with chronic periodontitis, decreased expression of TNFα [37] and COX-2 [39], and increased expression of IFN-γ were confirmed [40]. It is not known whether these aberrant methylations are specific to chronic periodontitis.…”

Section: Dna Methylation In Oral Inflammatory Diseasesmentioning

confidence: 97%

Epigenetics of oral infection and inflammatory diseases—DNA methylation changes in infections and inflammation diseases

Abiko

Uehara

Fukumoto

et al. 2014

Journal of Oral Biosciences

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“…As an inflammatory disease, periodontitis is known to alter the immune response, a complex process involving several factors with roles in the regulating of gene expression, including the cytokine network, gene polymorphisms, and epigenetic modulation . Epigenetic modulation involves changes in gene expression without changes in the DNA sequence .…”

Section: Introductionmentioning

confidence: 99%

Effect of smoking on the DNA methylation pattern of the SOCS1 promoter in epithelial cells from the saliva of patients with chronic periodontitis

Martinez

Villafuerte

Luchiari

et al. 2019

Journal of Periodontology

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Background The aim of the present study was to evaluate the methylation pattern in the suppressor of cytokine signaling 1 (SOCS1) gene in smokers and non‐smokers with chronic periodontitis (CP). Methods Methylation‐specific polymerase chain reaction (PCR) was performed to determine the methylation status of the SOCS1 promoter in 45 saliva samples from smokers and non‐smokers with CP. Results Cells from the saliva of CP patients who smoked were 7.08 times more likely to have a methylated SOCS1 promoter than cells from the saliva of non‐smoking patients. Conclusions SOCS1 gene promoter methylation, with its potential effects on the expression of this gene, seems to be a consequence of exposure to tobacco and not to periodontal disease. Further studies are needed to elucidate the relationship between the epigenetic control of immune response gene expression, exposure to environmental factors, and the development, progression, and prognosis of CP.

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Hypermethylation and low transcription of TLR2 gene in chronic periodontitis

Cited by 51 publications

References 44 publications

Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

Epigenetics of oral infection and inflammatory diseases—DNA methylation changes in infections and inflammation diseases

Effect of smoking on the DNA methylation pattern of the SOCS1 promoter in epithelial cells from the saliva of patients with chronic periodontitis

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