No abstract

During chemotherapy, patients with cancer present a more complex oral microbiota under favorable conditions for their development during immunosuppression, and these may be responsible for different serious local or systemic pathologies.

Background The aim of the present study was to evaluate the methylation pattern in the suppressor of cytokine signaling 1 (SOCS1) gene in smokers and non‐smokers with chronic periodontitis (CP). Methods Methylation‐specific polymerase chain reaction (PCR) was performed to determine the methylation status of the SOCS1 promoter in 45 saliva samples from smokers and non‐smokers with CP. Results Cells from the saliva of CP patients who smoked were 7.08 times more likely to have a methylated SOCS1 promoter than cells from the saliva of non‐smoking patients. Conclusions SOCS1 gene promoter methylation, with its potential effects on the expression of this gene, seems to be a consequence of exposure to tobacco and not to periodontal disease. Further studies are needed to elucidate the relationship between the epigenetic control of immune response gene expression, exposure to environmental factors, and the development, progression, and prognosis of CP.

No abstract

Messora. Quero agradecer por estes dois anos de aprendizado, sinto a necessidade de transmitir-lhes minha profunda admiração, que gera em mim a vocação pelo ensino. Devo a essa equipe a construção do meu currículo. Tive grande oportunidade de ter trabalhado com todos. Obrigado aos senhores pela sua dedicação, ajuda, por cada aporte e por me fazerem sentir que meus sonhos e metas as posso cumprir, transitando um caminho que posso desfrutar. À Profa. Dra. Esther Silveira Ramos da FMRP, pela dedicação, confiança, paciência, oportunidade de trabalhar em seu grupo, e pela orientação no desenvolvimento dessa dissertação.