Hyperlipidemia in Coronary Heart Disease III. EVALUATION OF LIPOPROTEIN PHENOTYPES OF 156 GENETICALLY DEFINED SURVIVORS OF MYOCARDIAL INFARCTION

Hazzard, William R.; Goldstein, Joseph L.; Schrott, Helmut G.; Motulsky, Arno G.; Bierman, Edwin L.

doi:10.1172/jci107333

Cited by 116 publications

(35 citation statements)

References 18 publications

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“…12 " 14 However, some of the unexamined relatives could have had hypercholesterolemia and, therefore, we cannot exclude a diagnosis of FCHL. In the remaining six patients, hyperlipidemia could not be detected in the family; again, some may have had FCHL or FHTG.…”

Section: Poorly-classified Hypertriglyceridemiamentioning

confidence: 98%

Triglyceride and cholesterol metabolism in primary hypertriglyceridemia.

Beil¹,

Grundy²,

Crouse³

et al. 1982

Arteriosclerosis

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To determine mechanisms of elevated plasma trlglycerldes (TG) in patients with primary hypertrlglyceridemlas, simultaneous studies were carried out on kinetics of very low density llpoproteln-triglycerides (VLDL-TG) and synthesis of cholesterol and bile acids. Sixteen hypertrlglyceridemlc patients with familial combined hyperllpldemla (FCHL) and 12 patients with poorly classified, primary hypertriglyceridemia were studied, and their results were compared to a series of normal and obese subjects previously studied In our laboratory. The mean value for transport (synthesis) of VLDL-TG in patients with FCHL was about twice normal. Although the upper normal synthesis rates overlapped with transport rates of some patients with FCHL, It appeared that the major cause of hypertriglyceridemia in FCHL was an elevated production of VLDL-TG. However, the height of the plasma TG in FCHL patients also was influenced by Individual clearance capacities for VLDL-TG, and fractional clearance rates In several seemed particularly low. Synthesis rates for cholesterol and/or bile acids were high In several patients with FCHL, suggesting simultaneous overproduction of VLDL-TG and sterols; however, Increased synthesis of both was not observed In all the patients. Most patients with poorly classified hypertriglyceridemia had overproduction of VLDL-TG, but an apparent reduction in clearance was common. In these patients, Increased synthesis of cholesterol and bile acids was Infrequent. Our results indicate that abnormally high production of VLDL-TG seemed to be the major factor In causing primary hypertriglyceridemia, but that clearance capacity can play an important role In determining the severity of the TG elevation. (Arteriosclerosis 2:44-57, January/February 1982)

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Section: Poorly-classified Hypertriglyceridemiamentioning

confidence: 98%

Triglyceride and cholesterol metabolism in primary hypertriglyceridemia.

Beil¹,

Grundy²,

Crouse³

et al. 1982

Arteriosclerosis

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“…The second paper (12) reports the analysis of family members, presents evidence for a newly recognized inherited disorder (combined hyperlipidemia), and suggests an approach to classifying hyperlipidemia on the basis of plasma lipid levels in relatives. The third paper (13) (14,15). The diagnosis of myocardial infarction was accepted when two of these three criteria were met: (a) compatible clinical history; (b) serial electrocardiograms showing development of a diagnostic Q wave or S-T segment elevation followed by T wave inversion (16); and (c) characteristic changes in activity of glutamicoxalacetic transaminase, lactic dehydrogenase, and/or creatine phosphokinase (17) and parenteral hyperalimentation after a small bowel resection.…”

Section: Introductionmentioning

confidence: 99%

Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTION

Goldstein¹,

Hazzard²,

Schrott³

et al. 1973

J. Clin. Invest.

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586

154

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“…Triglyceride concentrations in VLDL are 13% and 24% higher in hypercholesterolemic males and female nonusers, respectively, than in normolipidemics. Previously, twofold elevations were observed in the familial and polygenic hypercholesterolemic survivors of myocardial infarction studied by Hazzard et al 14 The higher VLDL levels associated with hypercholesterolemia may reflect a defect in VLDL catabolism that is related to the pathophysiology of the higher LDL concentrations or to an overproduction of VLDL with more LDL as a byproduct. 15 LDL triglyceride is 26% to 47% higher in hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 92%

Hyperlipidemia in the Pacific Northwest Bell Telephone Company Health Survey. Part 1. Lipoprotein cholesterol and triglyceride concentrations.

Walden¹,

Wahl²,

Knopp³

et al. 1983

Arteriosclerosis

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Lipoprotein triglyceride and cholesterol concentrations and characteristics are described in normolipidemic and in three categories of hyperlipidemic subjects participating in the Pacific Northwest Bell Telephone Company Health Survey. For this study, 350 white participants 20 to 59 years of age with cholesterol or triglyceride values exceeding the age, sex, and hormone-use specific, population-based 90th percentile values were defined as having hypercholesterolemia, hypertriglyceridemia, or combined hyperlipidemia; 722 participants were classified as normolipidemic. In hypercholesterolemia, very low density lipoprotein cholesterol and triglyceride and high density lipoprotein cholesterol concentrations were higher than in normolipidemia. In hypertriglyceridemia, high density lipoprotein cholesterol was significantly lower in men and women not using sex hormones and low density lipoprotein triglyceride was significantly higher in men and women using hormones compared to normolipidemia. In combined hyperlipidemia, high density lipoprotein cholesterol concentrations were lower than in normolipidemia, but higher than in pure hypertriglyceridemia. The presence of beta migrating very low density lipoprotein and chylomicrons was seen primarily in hypertriglyceridemic or combined hyperlipidemic men. Sinking prebeta lipoprotein was equally common (20%) among all normolipidemic and hypercholesterolemic subjects, but was less common (5% to 10%) in hypertriglyceridemic and combined hyperlipidemic men and female hormone users. Quantitative and qualitative lipoprotein abnormalities associated with hyperlipidemia were found to vary by gender and by sex hormone use in women and were often, but not always, more marked in men. (Arteriosclerosis 3:117-124, March/April 1983)

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Hyperlipidemia in Coronary Heart Disease III. EVALUATION OF LIPOPROTEIN PHENOTYPES OF 156 GENETICALLY DEFINED SURVIVORS OF MYOCARDIAL INFARCTION

Abstract: A B S T R A

Cited by 116 publications

References 18 publications

Triglyceride and cholesterol metabolism in primary hypertriglyceridemia.

Triglyceride and cholesterol metabolism in primary hypertriglyceridemia.

Hyperlipidemia in Coronary Heart Disease I. LIPID LEVELS IN 500 SURVIVORS OF MYOCARDIAL INFARCTION

Hyperlipidemia in the Pacific Northwest Bell Telephone Company Health Survey. Part 1. Lipoprotein cholesterol and triglyceride concentrations.

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