Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Implications in acute and chronic infections

Chen, Shuai; Lin, Guo; You, Xiaoqing; Lei, Lang; Li, Yanfen; Lin, Minkun; Luo, Kai; Yan, Fuhua

doi:10.1016/j.archoralbio.2014.06.004

Cited by 25 publications

(26 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may indicate that there is a microbiota-related regulating system that prevented those in the DM+HLP cohort from developing UTIs. This is consistent with the finding that, although the co-occurrence of hyperlipidemia and diabetes can increase the body's inflammatory response (Casqueiro et al, 2012; Chen S. et al, 2014), there were no indications of UTIs (by either asymptomatic bacteriuria or nitrite-positive samples) in the DM+HLP cohort.…”

Section: Discussionsupporting

confidence: 89%

“…Bifidobacterium has been shown to be able to reduce levels of intestinal endotoxins and improve the mucosal barrier, which results in reduced systemic inflammation (Cani et al, 2008). Although T2DM, hypertension, and hyperlipidemia can increase an individual's inflammatory response (Casqueiro et al, 2012; Mangin, 2014; Chen S. et al, 2014), the subjects in the DM, DM+HT, and DM+HLP cohorts did not have a higher incidence of UTIs (in the previous year) compared to the incidence of UTIs (0.5–0.7 per year) reported by Hooten et al in healthy women (Hooton et al, 1996). This may be due to the presence of bacteria in urine (such as Akkermansia and Bifidobacterium ) that help to combat the inflammatory responses caused by diabetes, hypertension, and hyperlipidemia in order to maintain healthy urinary conditions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations of Urinary Microbiota in Type 2 Diabetes Mellitus with Hypertension and/or Hyperlipidemia

et al. 2017

View full text Add to dashboard Cite

Evidence shows urine specimens from different women have different populations of bacteria. The co-occurrence of hypertension and hyperlipidemia in those with diabetes may alter the composition of urine and the microenviroment of the bladder in which bacteria live. The aim of this study was to characterize the urinary microbiota in women with type 2 diabetes mellitus only and those with diabetes plus hypertension and/or hyperlipidemia, and to explore whether the composition of the urinary microbiota is affected by fasting blood glucose, blood pressure, and blood lipids. We enrolled 28 individuals with diabetes only, 24 with diabetes plus hypertension, 7 with diabetes plus hyperlipidemia, and 11 with diabetes plus both hypertension and hyperlipidemia. Modified midstream urine collection technique was designed to obtain urine specimens. Bacterial genomic DNA was isolated using magnetic beads and the urinary microbiota was analyzed using the Illumina MiSeq Sequencing System based on the V3-V4 hypervariable regions of the 16S rRNA gene. Among the four cohorts, the diabetes plus hypertension cohort had the highest relative abundance of Proteobacteria. In contrast, the diabetes plus hyperlipidemia cohort had the lowest relative abundance of Proteobacteria. In addition, Escherichia and Gardnerella were not found in the diabetes plus hyperlipidemia cohort but they were found in all of the other cohorts. Cetobacterium was only present in the diabetes plus hypertension cohort. The most abundant bacteria in the diabetes only and diabetes plus hyperlipidemia cohorts was Lactobacillus, while Prevotella was the most abundant bacteria in the diabetes plus hypertension and diabetes plus hypertension and hyperlipidemia cohorts. Moreover, the relative abundance of Lactobacillus was significantly lower in the diabetes plus hypertension cohort than in the diabetes only and diabetes plus hyperlipidemia cohorts. Several bacteria were correlated with the participants' fasting blood glucose, blood pressure, and blood lipids. In conclusion, hypertension and/or hyperlipidemia and other patient factors can affect the composition of the urinary microbiota in those with diabetes. The insights from this study could be used to develop microbiota-based treatment for comorbid conditions, including urinary tract infections, in those with diabetes.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Alterations of Urinary Microbiota in Type 2 Diabetes Mellitus with Hypertension and/or Hyperlipidemia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…25,38,39,40 Our study found that patients with hyperlipidemia with periodontitis had higher GCF PC and MDA levels and lower GCF TAOC levels compared with systemically healthy subjects with periodontitis. Moreover, serum lipid levels varied according to periodontal status, but the difference was more pronounced among patients with hyperlipidemia than with normolipidemic subjects.…”

mentioning

confidence: 74%

“…By interfering directly with membrane-bound receptors and altering gene expression, serum lipids play a role in tissue response, which when compromised, may predispose a patient to periodontal disease or exaggerated periodontal destruction. 38,39 This study's finding of higher OS markers and lower TAOC levels in patients with hyperlipidemia with periodontitis compared with patients with normolipidemia with periodontitis may be an indication of alterations in tissue response caused by lipid mediators at this later stage of periodontal destruction.…”

mentioning

confidence: 97%

“…It has been claimed that the changes in lipid metabolism affect the host susceptibility via OS-related periodontal destruction. 25,38,39 In conclusion, increased OS and decreased TAOC level in the GCF of patients with hyperlipidemia and periodontal disease combination may be the possible cause of the alteration of host susceptibility to periodontal inflammation. Moreover, the bidirectional relationship between local periodontal and systemic factors should be taken into consideration in the treatment of patients with periodontal disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia

et al. 2017

View full text Add to dashboard Cite

Rabbit M1 and M2 macrophages can be induced by human recombinant GM‐CSF and M‐CSF

Yamane

Leung

2016

FEBS Open Bio

View full text Add to dashboard Cite

Macrophages can change their phenotype in response to environmental cues. Polarized macrophages are broadly classified into two groups: classical activated M1 and alternative activated M2. Characterization of human macrophages has been widely studied, but polarized macrophages in rabbits have not been characterized. We characterized rabbit macrophages that were polarized using human recombinant GM‐CSF and M‐CSF. GM‐CSF‐treated macrophages had higher mRNA expression of proinflammatory cytokines (M1 phenotype) than did the M‐CSF‐treated counterpart. By contrast, high levels of TGF‐β and IL‐10 expression (M2 phenotype) were found in M‐CSF‐treated macrophages. The present study may be useful to understand roles of polarized macrophages in rabbit disease models.

show abstract

Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Implications in acute and chronic infections

Cited by 25 publications

References 44 publications

Alterations of Urinary Microbiota in Type 2 Diabetes Mellitus with Hypertension and/or Hyperlipidemia

Alterations of Urinary Microbiota in Type 2 Diabetes Mellitus with Hypertension and/or Hyperlipidemia

Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia

Rabbit M1 and M2 macrophages can be induced by human recombinant GM‐CSF and M‐CSF

Contact Info

Product

Resources

About