Alterations of Urinary Microbiota in Type 2 Diabetes Mellitus with Hypertension and/or Hyperlipidemia

Liu, Fengping; Ling, Zongxin; Xiao, Yonghong; Yang, Qing; Wang, Baohong; Zheng, Li; Jiang, Ping; Li, Lanjuan; Wang, Wei

doi:10.3389/fphys.2017.00126

Cited by 29 publications

(32 citation statements)

References 54 publications

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“…We guess that these bacteria may have same influence on SFST which need to confirm. A previous study had found that high level of Prevotella was associated with the development of hypertension and hyperlipidemia ( Liu F. et al, 2017 ), which contrary in our study, the Prevotella was reduced in the SFTS patients. Furthermore, a former research had revealed that the content of Prevotella was same in patients with non-alcoholic fatty liver disease compared with healthy people ( Wang et al, 2016 ).…”

Section: Discussioncontrasting

confidence: 99%

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Wei

et al. 2018

Front. Microbiol.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus, and the number of SFTS cases increased year by year in China. Previous studies had indicated that gut microbiome closely associated with human health and diseases, including infection diseases, liver diseases, gastrointestinal diseases and metabolic diseases. The aim of this study is to investigate the alterations and involvements of gut microbial in SFTS patients. We compared the gut microbiome of 26 SFTS patients between 20 health controls using the Illumina MiSeq sequencing platform. Reduced gut microbiota diversity and dramatic shifts of fecal microbial composition in SFTS patients were observed compared with health controls. In the intestinal microbial of SFTS patients, the Lachnospiraceae and Ruminococcaceae which could produce short-chain fatty acids were clearly dropped compared with health people, meanwhile, Sutterella which have anti-inflammation properties were reduced too. On the contrary, some common opportunistic pathogens like Enterococcus and Streptococcus and endotoxin-producing bacteria Escherichia which could rise the risk of infections were increased in SFTS patients than healthy people, in addition lactate-producing bacteria Lactobacillaceae also significantly increased in SFTS patients. In addition, research findings on the correlation between gut microbiota and biochemical data found that the changes of gut microbiota of SFTS patients were closely associated with clinical symptoms, key serum enzymes, infection and mortality. These alterations of gut microbiome in SFTS patients suggest the potential contributions of gut microbial to the pathogenesis of SFTS.

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Section: Discussioncontrasting

confidence: 99%

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Wei

et al. 2018

Front. Microbiol.

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“…Furthermore, we observed a negative correlation of Faecalibacterium with TG in pregnant women. Several earlier studies showed contrasting results in gut microbiome of GDM (Crusell et al, 2018) or urinary microbiota in T2D plus hyperlipidemia (Liu et al, 2017). It could be attributed to the different species or strains of Faecalibacterium involved, which could be further verified by shot-gun sequencing-based metagenomics.…”

Section: Discussionmentioning

confidence: 98%

Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia

Liu

Pan

et al. 2019

Front. Physiol.

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Clinical gestational diabetes mellitus (GDM) is frequently associated with hyperlipidemia comorbidity. Altered human gut microbiome has been linked to GDM and hyperlipidemia, respectively but not the comorbid condition. We hypothesize that the occurrence of hyperlipidemia with GDM may be characterized by distinguishable gut microbiome and blood metabolomic patterns. We presented comprehensive microbiomic coupled with lipidomics analyses to characterize gut microbiota and lipometabolism of plasma samples in women with GDM only, hyperlipidemia only and those with diabetes plus hyperlipidemia, and to explore association of the gut microbiota composition with blood lipid profiles and clinical parameters of gestational diabetes with or without commodity. We found that the relative abundance of bacterial taxa Streptococcus , Faecalibacterium , Veillonella , Prevotella , Haemophilus and Actinomyces was significantly higher in diabetes plus hyperlipidemia cohorts. Moreover, several bacteria were correlated with fasting plasma glucose and blood lipid levels of the participants with GDM and hyperlipidemia. The altered plasma lipidome in subjects with diabetes plus hyperlipidemia suggested that characteristic blood lipid profiles were associated with the pathogenesis of gestational diabetes plus hyperlipidemia. Collectively, this study provides insights on changes in fecal microbiota and plasma lipidome to predict and characterize the development of gestational diabetes with lipid metabolic abnormality.

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“…Actinobacteria , Collinsella , Desulfovibrio , Enterobacteriaceae , Flavobacteria , Flavobacteriales , Lactobacillus and Porphyromonas were capable of distinguishing the genitourinary microbiomes of T2DM patients from those of healthy subjects 9 , 10 . Lactobacillus and Prevotella were predominant in all the four cohorts of T2DM patients in a previous study 12 : (1) T2DM only, (2) T2DM and hypertension, (3) T2DM and hyperlipidemia, and (4) T2DM, hypertension and hyperlipidemia. Bifidobacteriaceae , Thermaceae and Shuttleworthia could contribute to the presence of interleukin-8 in the urine of T2DM patients 11 .…”

Section: Introductionmentioning

confidence: 68%

“…Recently, the genitourinary microbiomes of T2DM cohorts have been studied to achieve different objectives 10 – 12 . Actinobacteria , Collinsella , Desulfovibrio , Enterobacteriaceae , Flavobacteria , Flavobacteriales , Lactobacillus and Porphyromonas were capable of distinguishing the genitourinary microbiomes of T2DM patients from those of healthy subjects 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Multiple bacteria associated with the more dysbiotic genitourinary microbiomes in patients with type 2 diabetes mellitus

Zha

Liu

Ling

et al. 2021

Sci Rep

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Type 2 diabetes mellitus (T2DM) influences the human health and can cause significant illnesses. The genitourinary microbiome profiles in the T2DM patients remain poorly understood. In the current study, a series of bioinformatic and statistical analyses were carried out to determine the multiple bacteria associated with the more dysbiotic genitourinary microbiomes (i.e., those with lower dysbiosis ratio) in T2DM patients, which were sequenced by Illumina-based 16S rRNA gene amplicon sequencing. All the genitourinary microbiomes from 70 patients with T2DM were clustered into three clusters of microbiome profiles, i.e., Cluster_1_T2DM, Cluster_2_T2DM and Cluster_3_T2DM, with Cluster_3_T2DM at the most dysbiotic genitourinary microbial status. The three clustered T2DM microbiomes were determined with different levels of alpha diversity indices, and driven by distinct urinalysis variables. OTU12_Clostridiales and OTU28_Oscillospira were likely to drive the T2DM microbiomes to more dysbiotic status, while OTU34_Finegoldia could play a vital role in maintaining the least dysbiotic T2DM microbiome (i.e., Cluster_1_T2DM). The functional metabolites K08300_ribonuclease E, K01223_6-phospho-beta-glucosidase and K00029_malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) were most associated with Cluster_1_T2DM, Cluster_2_T2DM and Cluster_3_T2DM, respectively. The characteristics and multiple bacteria associated with the more dysbiotic genitourinary microbiomes in T2DM patients may help with the better diagnosis and management of genitourinary dysbiosis in T2DM patients.

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Alterations of Urinary Microbiota in Type 2 Diabetes Mellitus with Hypertension and/or Hyperlipidemia

Cited by 29 publications

References 54 publications

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome

Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia

Multiple bacteria associated with the more dysbiotic genitourinary microbiomes in patients with type 2 diabetes mellitus

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