Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia

Abstract

Clinical gestational diabetes mellitus (GDM) is frequently associated with hyperlipidemia comorbidity. Altered human gut microbiome has been linked to GDM and hyperlipidemia, respectively but not the comorbid condition. We hypothesize that the occurrence of hyperlipidemia with GDM may be characterized by distinguishable gut microbiome and blood metabolomic patterns. We presented comprehensive microbiomic coupled with lipidomics analyses to characterize gut microbiota and lipometabolism of plasma samples in women with GDM only, hyperlipidemia only and those with diabetes plus hyperlipidemia, and to explore association of the gut microbiota composition with blood lipid profiles and clinical parameters of gestational diabetes with or without commodity. We found that the relative abundance of bacterial taxa Streptococcus , Faecalibacterium , Veillonella , Prevotella , Haemophilus and Actinomyces was significantly higher in diabetes plus hyperlipidemia cohorts. Moreover, several bacteria were correlated with fasting plasma glucose and blood lipid levels of the participants with GDM and hyperlipidemia. The altered plasma lipidome in subjects with diabetes plus hyperlipidemia suggested that characteristic blood lipid profiles were associated with the pathogenesis of gestational diabetes plus hyperlipidemia. Collectively, this study provides insights on changes in fecal microbiota and plasma lipidome to predict and characterize the development of gestational diabetes with lipid metabolic abnormality.

Association Of Gut Microbiota During Early Pregnancy With Risk Of Incident Gestational Diabetes Mellitus: A Nested Case-Control Study

“…Since Actinobacteria was reported to correlate positively with in ammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) levels [22], as a whole phylum it could be a good target for treatment to prevent host from developing GDM. However, other con icting results from previous studies reported over-represented Actinobacteria in aberrant gut microbiota of pregnant women [6,21] and type 2 diabetes mellitus patients [23,24]. This may due to elevated Collinsella of Actinobacteria that have potential deleterious effects on regulation of glucose metabolism in middle and late stage of pregnancy [6,21,25], while such deleterious members were not signi cantly different between GDM cases and controls in our study.…”

Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations

“…In humans, the diversity of the gut microbiome has been found to have a negative association with BMI and serum triacylglycerols (TGs) [ 9 ]. Liu et al reported that gestational diabetes mellitus comorbidity was strongly associated with both a specific gut microbial composition and with the circulating lipidome [ 10 ]. Here, relative abundances of Faecalibacterium and Prevotella showed linkage with circulating lipids, in particular with lysophosphatidylethanolamine, and phosphatidylglycerols.…”

Altered gut bacterial and metabolic signatures and their interaction in gestational diabetes mellitus

“…Disturbances of fecal and blood metabolic signatures were also reported in GDM. 18 Given that the gut microbiome modulates diverse host metabolic pathways, it is important to simultaneously characterize how microbial and metabolic signatures change and interact in GDM.…”