Hyperlipidemia as a predictor of physical functioning for stroke

Abstract

Objective: Elevated cholesterol levels contribute to changes of the arterial endothelial permeability. Hyperlipidemia promotes atherosclerosis and is associated with an increased risk of stroke incidence. The purpose of this study was to investigate the effects of having a history of hyperlipidemia prior to a stroke incidence on postural balance, anticipatory dynamic postural control, gait endurance and gait performance in individuals with hemiparetic stroke. Design: Cross-sectional study. Methods: Fifty-two adults who were diagnosed with stroke 6 months ago or more were enrolled in this study. They were divided into two different groups according to hyperlipidemia history before stroke. All participants were assessed with the Activities-specific into Balance Confidence (ABC) scale, Berg Balance scale (BBS), Dynamic Gait Index (DGI), Timed Up and Go test (TUG), and the 6-minute walk test (6MWT). An independent t-test was used to analyze the difference between the hyperlipidemia group and non-hyperlipidemia group. Results: After analysis, the BBS, TUG, and 6MWT scores were significantly different between the hyperlipidemia and non-hyperlipidemia group, but not the ABC and DGI scores. Conclusions:The results of this study show that having a history of hyperlipidemia before stroke affects static and dynamic postural balance performance, anticipatory dynamic postural balance, and gait endurance in individuals with chronic hemiparetic stroke. Based on the results of this study, we also suggest treatment for hyperlipidemia should be implemented throughout the therapeutic interventions, such as pharmacological or exercise programs, in order to restore the physical function of stroke survivors.

Predictors for Returning to Paid Work after Transient Ischemic Attack and Minor Ischemic Stroke

“…Approximately half of ischemic stroke patients are diagnosed with hyperlipidemia [ 29 ] (~70% in our sample), which makes it a predominant cause of stroke occurrence [ 30 ] while its consequences regarding post-stroke recovery remain largely unexplored. Accordingly, Sim et al [ 12 ] illustrated in a sample of hemiparetic stroke patients that a history of hyperlipidemia was related with impairments in physical functioning while Xu et al [ 11 ] showed that higher serum levels of triglycerides, low- and high-density lipoprotein cholesterol levels lead to increased NIHSS and death rate at discharge. More specifically, Zeljkovic et al [ 31 ] reported that solely LDL-C (and not HDL-C) was related to the occurrence of acute ischemic stroke and further in-hospital mortality rate.…”

“…Moreover, emotional factors such as psychological well-being [ 10 ] as well as lesion size and location [ 3 ] have been reported as predictors. Finally previous cardiovascular risk factors such as high blood pressure and hyperlipidemia possibly mediated through increasing stroke severity [ 11 ] and post-stroke physical disabilities [ 12 ] have been suggested to indirectly impact RTW propensity [ 13 , 14 ].…”

Swimming training on moderate intensity significantly reduces total cholesterol and bodyweight on hypercholesterolemic rat model

“…Hyperlipidemia is a condition occurred due to lipid metabolism disorder in the human body, resulting in elevation of one or more plasma lipid concentration in blood, including the increase of triglycerides (TC) or hypertriglyceridemia; total cholesterol (TC) or hypercholesterolemia, low density lipoprotein or hyper-LDL cholesterolemia, and very low density lipoprotein (VLDL), along with the decrease of high density lipoprotein (HDL) (He & Ye, 2020;Shattat, 2014;Vafa et al, 2011). The alterations of these different forms of lipids cause atherosclerosis which is characterized by the accumulations of plaques on the arterial walls, resulting in the narrowing and blockage of blood vessels (Sim et al, 2018;Wu et al, 2017). Atherosclerosis is associated with an increased risk of cardiovascular diseases, a number one leading cause of death and morbidity worldwide, taking over 17,9 million lives each year globally (Roever et al, 2017;WHO, 2017).…”