Hyperleukocytosis, leukostasis and leukapheresis: Practice management

Ganzel, Chezi; Becker, Joanne; Mintz, Paul D.; Lazarus, Hillard M.; Rowe, Jacob M.

doi:10.1016/j.blre.2012.01.003

Cited by 182 publications

(236 citation statements)

References 43 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…(1) Hyperleukocytosis is a relevant prognostic factor in several types of leukaemias. (2) In acute leukaemia it carries a high early mortality rate. (3) Hyperleukocytosis can cause leukostasis syndrome, the accumulation of leukemic cells within the capillary lumen, resulting in neurological and pulmonary manifestations that can lead to intracranial haemorrhage and respiratory failure.…”

Section: Discussionmentioning

confidence: 99%

Migraine due to intraparenchymal hemorrhage during a blast crisis

2013

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Migraine due to intraparenchymal hemorrhage during a blast crisis

2013

View full text Add to dashboard Cite

show abstract

“…Bu sebeple tüm hastalarda tanı anında kemik iliği örneğinden sitogenetik inceleme yapılmalıdır 1 Mutlak nötrofil sayımı 500/mm3'ün altında olması sıklıkla yaşamı tehdit eden enfeksiyonlarla ilişkilidir 1 . AML hastalarında hiperlökositoz (>100.000/mm 3 ) insidansı %20 olarak saptanmıştır, sıklıkla pulmoner ve nörolojik sistem bulgularıyla karşımıza çıkar 8,9 . Yapılan çalışmalar AML M1, M4, M5, inv 16 ve FLT3-ITD pozitif olan hastalarda hiperlökositoz riskinin arttığını göstermiştir …”

Section: Who 2008 Sınıflamasıunclassified

Çocukluk Çağında Akut Myeloid Lösemi

Yöntem¹,

Bayram²

2018

Arşiv Kaynak Tarama Dergisi

View full text Add to dashboard Cite

Acute leukemia is basically divided into acute lymphoblastic leukemia and acute myeloid leukemia (AML). About 15-20% of childhood leukemia is caused by AML. AML is classified according to morphological, cytochemical and immunophenotypic characteristics. AML patients may present with various clinical signs and symptoms due to leukemic cell infiltration. Age, gender, race, structural features of the patient and cytogenetic abnormalities are important factors affecting prognosis in AML. The goal in the treatment of AML is to provide complete remission with the least toxicity given to the patient and to maintain this remission. In this study, etiology, classification, clinical features, prognosis and treatment strategies of childhood AML were investigated.

show abstract

“…Цитокиновая теория основана на феномене взаимодей-ствия лейкемических клеток и эндотелия. Известно, что бластные клетки способны активировать клетки эндотелия путем секреции цитокинов (в частности, α-фактора некро-за опухоли, интерлейкина-1β), в результате чего опосредо-ванно, через специфические рецепторы адгезии (селекти-ны, молекулы сосудистой клеточной адгезии-1) возникает бластно-эндотелиальное взаимодействие, а затем происхо-дит агрегация бластных клеток в микроциркуляторном русле [3].…”

Section: терапевтический архив 7 2015unclassified

“…В среднем для достижения лейкоредукции, позволившей на-чать проведение индукционной ХТ (до 50-70·10 9 /л), по-требовалось 1-2 (медиана 2) процедуры лейкоцитафереза. Аналогичные данные приводят и зарубежные исследовате-ли [3,26,27]. Объемы возмещения составили за 1 процеду-ру 500-1000 мл кристаллоидов, части больным дополни-тельно вводили 50-100 мл 10-20% альбумина.…”

unclassified