Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behçet's disease

Feki, Moncef; Houman, H.; Ghannouchi, Mohamed Mehdi; Smiti-Khanfir, Monia; Hamzaoui, K; Matri, L. El; Mebazaa, Abderraouf; Kaabachi, N.

doi:10.1515/cclm.2004.263

Cited by 30 publications

(22 citation statements)

References 34 publications

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“…However, the association between hcy and thrombosis remains statistically significant in many of the studies that considered in the analysis the impact of other potential risk factors, such as male sex or smoking habits. 8,12,25,[27][28][29][30]32,34,35 Furthermore, hcy appeared to be a risk factor for thrombosis even in the 2 studies in which immunosuppressive therapy had been withdrawn before measurement. 28,36 Third, 3 studies 4,25,28 have included also some patients with aneurysms as vascular manifestations.…”

Section: Discussionmentioning

confidence: 99%

“…Sixteen studies were therefore included in our systematic review. 4,7,11,24 -36 The studies performed by Houman et al 35 and Feki et al 34 may have considered in part the same population. However, both the studies were included in our metaanalysis because they considered different end points (Feki et al measured mean hcy levels, and Houman et al assessed the presence of hyperhomocysteinemia).…”

Section: Study Identification and Selectionmentioning

confidence: 99%

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Homocysteine in Vascular Behçet Disease

Regina

Orlandini

Prisco

et al. 2010

ATVB

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Objective-Behçet disease (BD) is a vasculitis of unknown etiology, characterized by oral or genital aphtosis and uveitis.Homocysteine (hcy) is an independent risk factor for venous and arterial thrombosis. The association between hyperhomocysteinemia and thrombosis has been investigated in some studies in BD patients. However, information on this association is based only on the results of small studies with conflicting results. To overcome such limitations, we performed a metaanalysis comparing the plasma levels of hcy in BD patients with and without history of thrombosis. Methods and Results-We searched for all published studies using the Medline and Embase databases. Two reviewers performed study selection independently. Studies were included if hcy was measured in adult BD patients with and without thrombosis. Two reviewers independently extracted data on study and population characteristics. The mean value of hcy in BD patients and the presence of hyperhomocysteinemia in patients with and without thrombosis were collected. Association between thrombosis and hyperhomocysteinemia, and the mean difference of hcy levels in BD patients with and without thrombosis were calculated. Sixteen studies, for a total of 979 patients, were included. Hyperhomocysteinemia was more prevalent in patients with thrombosis than in those without (odds ratio 3.14; 95% CI 1.26 to 7.80) Mean levels of hcy were significantly higher in patients with thrombosis in comparison with patients without (mean difference 3.30 mol/L; 95% CI 2.09 to 4.51). This high prevalence of thromboses, known since the 1950s, 3 promoted several studies aimed at investigating their pathobiology. Endothelial injury itself, common to other vasculitis, cannot clearly account for thrombosis development, so a hypercoagulable state was early hypothesized and investigated. 4 In the last several years, several inherited or acquired factors causing hypercoagulability have been studied in patients with venous and arterial thromboembolic events. 5-7 These thrombophilic factors have also been studied in patients with BD with a history of thrombosis, and conflicting results were obtained. 8 -11 Recently, Ricart et al performed a metaanalysis evaluating the role of FV Leiden, prothrombin G2021A mutation, and the homozygous 677TT mutation of the methyltetrahydrofolate reductase as risk factors for venous thrombosis in BD patients. 12 In this study, FV Leiden and G2021A prothrombin mutation were found to increase the risk of thrombosis in these patients, whereas 677TT mutation of methyltetrahydrofolate reductase did not. Conclusion-OurThese findings are consistent with the results of recent studies performed in general populations in which the presence of 677TT mutation of methyltetrahydrofolate reductase is not a risk factor for venous thromboembolism in the absence of hyperhomocysteinemia. 13 On the other hand, in the general population, increased levels of homocysteine (hcy) have been reported to be an independent risk factor for venous thromboembolism in addition to c...

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Section: Discussionmentioning

confidence: 99%

Section: Study Identification and Selectionmentioning

confidence: 99%

Homocysteine in Vascular Behçet Disease

Regina

Orlandini

Prisco

et al. 2010

ATVB

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“…Hyperhomocysteinaemia was significantly higher in our male patients. It was found in the studies of Ates et al [18] and Feki et al [23]. These studies are summarized in Table 5.…”

Section: Discussionmentioning

confidence: 85%

“…Our present results showed that serum tHcy levels and HHCY were higher in the active patients than those of the inactive patients and the control subjects. It was demonstrated by Feki et al [23], Ates et al [18], Sarican et al [21], and Aksu et al [13]. …”

Section: Discussionmentioning

confidence: 97%

Hyperhomocysteinaemia in Behçet's Disease

Hamzaoui

Harzallah²,

Klii³

et al. 2010

Biochemistry Research International

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Objectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD). Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fifty healthy volunteers matched for age and sex with the BD group were included as a negative control group. Patients, with any condition that might affect plasma homocysteine concentration, were excluded. Results. Mean serum homocysteine concentration was significantly higher in patients with BD than in the healthy controls (P < .001), in patients with active disease (P = .04), and in masculine gender (P = .05). There was no significant difference between homocysteine level and clinical involvement. Conclusions. We demonstrated that plasma total homocysteine level (tHcy) is increased in BD and correlated with disease activity. No association was found between homocysteine levels and clinical involvement.

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“…Hyperhomocysteinemia was related to male gender, disease severity, and uveitis. The association between uveitis and hyperhomocysteinemia persisted after adjusting for gender, age, disease activity and duration, smoking, deep venous thrombosis, and serum concentrations of creatinine, vitamin B 12 , and folate [30].…”

Section: Pathogenesismentioning

confidence: 88%

Visual aspects of behçet’s disease

Kansu

Kadayıfçılar

2006

Curr Treat Options Neurol

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Behçet's disease is a systemic vasculitis characterized by recurrent oral and genital ulcers and ocular inflammation. The disease may also involve the joints, skin, central nervous system, the lungs, and gastrointestinal tract. Ocular manifestations include anterior uveitis, posterior uveitis, macular edema, retinal vasculitis, conjunctival ulcers, optic neuropathy, papilledema, secondary glaucoma, cataract, and neovascularization of iris or retina. The cause of Behçet's disease is unknown, but autoimmune and genetic factors are considered important in its pathogenesis. Promising new imaging techniques and treatments are available to provide better management for patients. This review focuses on recent data on visual aspects, pathogenesis, and the treatment of Behçet's disease.

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Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behçet's disease

Cited by 30 publications

References 34 publications

Homocysteine in Vascular Behçet Disease

Homocysteine in Vascular Behçet Disease

Hyperhomocysteinaemia in Behçet's Disease

Visual aspects of behçet’s disease

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