Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ: Interchangeable cancer promoters

Cole, Laurence A.; Butler, Stephen A.

doi:10.1016/j.mce.2011.10.029

Cited by 81 publications

(71 citation statements)

References 37 publications

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“…Studies with hCG and cancer show that cancer cells produce a hyperglycosylated hCG free β-subunit, which retains the TGF-β-II receptor binding potential and activating the TGF-β-II receptor [4,6,29]. Studies show, that while the hormone hCG has no TGF-β-II activity, that dissociated hormone hCG β-subunit has full TGF-β-II biological activity [4,24,25]. Many researchers have used dissociated hormone β-subunit to stimulate cancer cells [4,6].…”

Section: Discussionmentioning

confidence: 99%

“…It is established that the TGF-β-II receptor binds hyperglycosylated hCG dissociation products (nicked hyperglycosylated hCG β-subunit), and hyperglycosylated hCG free β-subunit as produced by nontrophoblastic neoplasms [4,24,25]. As such, the receptor contains a β-subunit-specific binding site.…”

Section: Discussionmentioning

confidence: 99%

“…It controls deep implantation of hemochorial placentation at the end of the first trimester of pregnancy [22], controls placenta growth during pregnancy [23] and controls malignancy by all human cancer cells [24,25].…”

Section: Introductionmentioning

confidence: 99%

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The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

Cole¹

2017

J Glycobiol

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Introduction: In 1997 I discovered hyperglycosylated hCG, a separate and independent molecule to the hormone hCG. The structure of hyperglycosylated hCG was also examined, it was a molecule varying from hCG by just 3 or 4 small sugar side chains, or 2.8% of molecular weight. While the hormone hCG binds a luteinizing hormone (LH)/hCG hormone receptor, hyperglycosylated hCG and its β-subunit are autocrines binding and antagonizing a TGF-β-II receptor. Here structural differences between the two molecules are investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

Cole¹

2017

J Glycobiol

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“…Hyperglycosylated hCG (H hCG) plays an essential role in angiogenesis, immunosuppression, and growth during pregnancy. Studies have already demonstrated measuring H hCG is useful in diagnosing gestational trophoblastic neoplasia (GTN) [14][15][16]. When hCG is excreted into urine, it is degraded to "nicked" forms [17,18].…”

Section: Discussionmentioning

confidence: 99%

Elevated Human Chorionic Gonadotrophin Due to Pancreatic Cancer

Manohar¹,

Werner²,

Murphy³

2012

OJAnes

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Preoperative pregnancy testing is common practice among anesthesiologists. Little is re-ported in anesthesia literature on causes other than pregnancy for elevated human chorionic go-nadotrophin (hCG) levels. Among these causes is hCG secretion by tumors. This is a report of a female with pancreatic cancer that presented for a Whipple procedure, who on routine pregnancy testing was found to have an elevated hCG level. This unexpected result led to significant delay and undue stress for the patient. After determining pregnancy was unlikely and multiple poorly differentiated metastatic masses were discovered, it was decided that the most likely cause of her hCG levels was cancer. Multiple cancers have been reported to secrete hCG, and more specifically β hCG [1]. Studies of elevated hCG in pancreatic cancer patients report an incidence of 40% -56% [2,3]. Serum β hCG testing done prior to the date of surgery (DOS) in cancer patients that are pre-or perimenopausal should be considered as it would allow time for a more definitive pregnancy evaluation to be performed.

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“…In addition, hCG-H has a particular double molecular size O-linked oligosaccharide when compared with the normal trisaccharide structures (19). The roles of hCG-H include promoting the invasion and growth of choriocarcinoma and reproductive cancer cells, as well as driving malignancy in these cancers (20).…”

mentioning

confidence: 99%

Recognition of N-Glycoforms in Human Chorionic Gonadotropin by Monoclonal Antibodies and Their Interaction Motifs

Zhang

et al. 2015

Journal of Biological Chemistry

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Background:The N-linked oligosaccharides of human chorionic gonadotropin become more complicated in cancer. Results: MCA1024 alters its binding affinity against different human chorionic gonadotropin glycoforms. Conclusion:The N-glycosylations at Asn-13 and Asn-30 on the ␤ subunit are crucial to the binding affinity of MCA1024. Significance: The aberrant glycosylation of cancer biomarkers might potentially be monitored by specific antibodies.

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Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ: Interchangeable cancer promoters

Cited by 81 publications

References 37 publications

The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

Elevated Human Chorionic Gonadotrophin Due to Pancreatic Cancer

Recognition of N-Glycoforms in Human Chorionic Gonadotropin by Monoclonal Antibodies and Their Interaction Motifs

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