Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy

Hosokawa, Takanori; Kurosaki, Masayuki; Tsuchiya, Kaoru; Matsuda, Shuya; Muraoka, Masaru; Suzuki, Yuichiro; Tamaki, Nobuharu; Yasui, Yutaka; Nakata, Toru; Nishimura, Takashi; Suzuki, Shinichi; Ueda, Ken; Nakanishi, Hiroyuki; Itakura, Jun; Takahashi, Yuka; Izumi, Namiki

doi:10.3748/wjg.v19.i2.249

Cited by 49 publications

(42 citation statements)

References 42 publications

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“…Insulin resistance prior to cancer treatment was identified as an independent negative factor influencing overall survival, progression-free survival and development of treatment resistance in various cancer types [28,[77][78][79][80][81][82]. A retrospective study in 130 lymphoma patients identified high fasting blood glucose levels at diagnosis as a predictor of decreased overall-and progression-free survival [77].…”

Section: Influence Of Insulin and Glucose Levels On Therapy Efficacymentioning

confidence: 99%

Cancer-drug induced insulin resistance: Innocent bystander or unusual suspect

Ariaans

Jong

Gietema

et al. 2015

Cancer Treatment Reviews

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Section: Influence Of Insulin and Glucose Levels On Therapy Efficacymentioning

confidence: 99%

Cancer-drug induced insulin resistance: Innocent bystander or unusual suspect

Ariaans

Jong

Gietema

et al. 2015

Cancer Treatment Reviews

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“…Nine studies [79][80][81][82][83][84][85][86][87] assessed the association between alcohol consumption and survival in hepatocellular carcinoma patients (Supplementary table 3). Many of these studies used measures of historical heavy alcohol consumption rather than current alcohol use.…”

Section: Alcohol and Survival In Liver Cancer Patientsmentioning

confidence: 99%

Do smoking and alcohol behaviours influence GI cancer survival?

McMenamin

McCain

Kunzmann

2017

Best Practice & Research Clinical Gastroenterology

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Little is known about the role of alcohol and smoking in GI cancer survival compared to GI cancer development. We systematically reviewed the evidence for a role of smoking and alcohol in prognosis among GI cancer patients and inform whether smoking or alcohol cessation interventions or guidelines for GI cancer patients are likely to improve prognosis. A total of 84 relevant studies were identified. Continued smokers, particularly heavy smokers, had worse prognosis than never smokers in most GI cancers. However, more evidence is needed to establish the likely impact of smoking cessation interventions amongst GI cancer patients. Heavy alcohol drinkers had worse prognosis in oesophageal squamous cell carcinoma and hepatocellular carcinoma patients. Light alcohol consumption was not associated with worse prognosis from any GI cancer, though further studies are needed. UK guidelines for the general population recommending under 14 units (∼7 drinks) per week may be sufficient for GI cancer patients, until further evidence is available.

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“…11 Furthermore, metabolic factors, such as diabetes mellitus and hyperglycemia, were also reported to be related to recurrence after RFA. 12,13 Thus, various systemic factors, not only tumor factors but also host factors, are associated with recurrence.…”

Section: Introductionmentioning

confidence: 99%