Neutrophil‐to‐lymphocyte ratio predicts recurrence after radiofrequency ablation in hepatitis B virus infection

Tajiri, Kazuto; Baba, Hayato; Kawai, Kengo; Minemura, Masami; Yasumura, Satoshi; Takahara, Taro; Sugiyama, Toshiro

doi:10.1111/jgh.13287

Cited by 40 publications

(30 citation statements)

References 37 publications

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“…NLR, a biomarker of tumor inflammation and host immunity, was associated with increased mortality in cancer (35).In agreement with the results of our study Chen et al(36) , Dan et al(37) and Tajiriet al (38) reported that high postoperative NLR is associated with high recurrence rate of HCC after RFA.…”

Section: Discussion:-supporting

confidence: 83%

Aspartate Aminotransferase to Platelet Ratio Index Versus Neutrophil to Lymphocyte Ratio for Prediction of Post Radiofrequency Ablation Recurrence of Hepatocellular Carcinoma.

Sallam.¹,

Fawzy.²,

Elsadek.³

2017

IJAR

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Background & Aims:Tumor recurrence after curative radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) is common. The burden of frequent post-ablation investigations especially triphasic computerized tomography (TCT) is high. We investigated whether post ablation measurement of aspartate aminotransferase to platelet ratio index (APRI) and neutrophil to lymphocyte ratio (NLR) as simple and cheap biomarkers can precisely predict HCC recurrence and which of them is more valuable. Methods: In this retrospective study, the demographic, clinical, laboratory and imaging data of 42 HCC patients treated with RFA were statistically analyzed. Patients were classified into two groups; those with HCC recurrence (group I) and those without (group II). In order to test the value of baseline NLR versus that of APRI in predicting tumor recurrence and compare both to alfa fetoprotein (AFP), we used receiver operating curve (ROC) statistics. Results: Mean values of AST, Platelets count, APRI, NLR and AFP showed significant correlation with HCC recurrence. Using logistic regression analysis, NLR was the only independent risk factor predicting HCC recurrence. NLR had the highest sensitivity and specificity for prediction of HCC recurrence (90.9 % and 85%) followed by that of AFP (86.4 % and 75%), and lastly by that of APRI (72.7% and 70%). Conclusion: NLR is a promising, simple and cheap surrogate marker for prediction of HCC recurrence after radiofrequency ablation, and is far more significant than APRI. .

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Section: Discussion:-supporting

confidence: 83%

Aspartate Aminotransferase to Platelet Ratio Index Versus Neutrophil to Lymphocyte Ratio for Prediction of Post Radiofrequency Ablation Recurrence of Hepatocellular Carcinoma.

Sallam.¹,

Fawzy.²,

Elsadek.³

2017

IJAR

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“…Similarly, a NLR >2.5 prior to interventional locoregional radiotherapy with radiofrequency ablation for HCC was significantly associated with tumor recurrence in patients infected with HBV (8). Although these previous studies reported prognostic value in NLR following treatment for HBV-related HCC, few examined changes in NLR related to initiation of antiviral treatment.…”

Section: Discussionmentioning

confidence: 93%

Profiling Neutrophil–to–Lymphocyte Ratio Changes in Response to Nucleoside Analog Therapy for Chronic Hepatitis B Infection

Marallag

Patel

Choi

et al. 2017

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“…Several studies had established that a higher NLR was independently associated with early mortality and poor clinical outcomes of HBV-related decompensated liver cirrhosis, resectable and advanced HCC after treatments (radical hepatectomy, radiofrequency ablation, transarterial chemoin vivo 31 embolization, liver transplantation) (31)(32)(33)(34)(35). Our recent analysis revealed that peginterferon was superior to nucleos(t)ide in reducing HCC risk (9), and immunomo-dulation may play a significant role.…”

Section: Discussionmentioning

confidence: 99%

Clinical Predictors for Neutrophil–to–Lymphocyte Ratio Changes in Patients with Chronic Hepatitis B Receiving Peginterferon Treatment

Liang

Chang

et al. 2017

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Abstract. Background: A lower neutrophil-to-lymphocyte ratio (NLR) was found to be associated with better clinical outcomes in hepatitis B (adjusted p=0.028, 0.005, and 0.028, respectivelyHepatitis B virus (HBV) infection is a global public health issue. There are about 250 million HBV carriers in the world, of whom roughly 600,000 die annually from HBVrelated liver disease, including liver cirrhosis and hepatocellular carcinoma (HCC) (1-4). Interferon and nucleos(t)ide analogs are two major classes of antiviral therapies against HBV. Both are capable of reducing the incidence of HCC (5-8). In view of HCC prevention, peginterferon remains superior to nucleos(t)ide analogs (9). One possible reason for this is the emergence of HBV surface antigen truncation mutations, which had increased oncogenic potentials, in patients receiving long-term nucleos(t)ide analogue therapy (9-11) and the other is the immunomodulatory properties of peginterferon, which is believed to exert anticancer effect (12).One of the major contributing factors for HCC development, recurrence and metastasis is the imbalance of inflammatory response (13-15). Several indicators of systemic inflammation, such as C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR) and modified Glasgow prognostic score have been used for evaluation of inflammatory status. Neutrophils and lymphocytes are the essential components of the tumor-related stroma, and are closely correlated to local inflammation and immune responses (16). Because blood neutrophil and lymphocyte counts are routinely checked during clinical practice, NLR is widely used as a reference for immunological status of the patients (17). Nowadays, a higher NLR has been correlated with poorer prognosis in several malignancies (18-23), including resectable and advanced . In this way, lower NLR seems to imply a lower risk and better outcome of HCC in chronic HBV-infected patients. We, therefore, hypothesized that the NLR change post peginterferon treatment might provide an explanation for its superior HCCprevention effect. Searching the literature, there is no study focusing on the change of NLR after peginterferon treatment in chronic hepatitis B patients. In this study, we aimed to clarify this important issue. 723

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Neutrophil‐to‐lymphocyte ratio predicts recurrence after radiofrequency ablation in hepatitis B virus infection

Abstract: Recurrence of HCC after RFA was strongly associated with survival. NLR is useful as a predictive marker of recurrence, especially in HBV-HCC patients.

Cited by 40 publications

References 37 publications

Aspartate Aminotransferase to Platelet Ratio Index Versus Neutrophil to Lymphocyte Ratio for Prediction of Post Radiofrequency Ablation Recurrence of Hepatocellular Carcinoma.

Aspartate Aminotransferase to Platelet Ratio Index Versus Neutrophil to Lymphocyte Ratio for Prediction of Post Radiofrequency Ablation Recurrence of Hepatocellular Carcinoma.

Profiling Neutrophil–to–Lymphocyte Ratio Changes in Response to Nucleoside Analog Therapy for Chronic Hepatitis B Infection

Clinical Predictors for Neutrophil–to–Lymphocyte Ratio Changes in Patients with Chronic Hepatitis B Receiving Peginterferon Treatment

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