Hyperglycemia Following the Portal Injection of Insulin.

The Physiologic Significance of the Secretion of Endogenous Insulin Into the Portal Circulation. I. Comparison of the Effects of Glucagon-Free Insulin Administered via the Portal Vein and via a Peripheral Vein on the Magnitude of Hypoglycemia and Peripheral Glucose Utilization1

“…Arteriovenous glucose differences were not measured, and the studies were concerned primarily with the hyperglycemic effect of insulin (18,19) (6,24). For these reasons the effects obtained with insulin known to contain glucagon are not comparable to those obtained with glucagon-free insulin.…”

The Effect of Glucagon on Net Splanchnic Balances of Glucose, Amino Acid Nitrogen, Urea, Ketones, and Oxygen in Man*

“…For some time the liver has been known to play a primary role in the mediation of this effect (2,3). More recently, Shoemaker, Van Itallie, and Walker (4, 5) demonstrated a marked increase in hepatic glucose output in dogs after the administration of glucagon.…”

Efeitos do Glucagon no metabolismo glicídico de Chrysemys d'orbignyi (Reptilia, Chelonia) sob a influência das variações estacionais

“…Coube a M urlin e colaboradores investigar, pela prim ei ra vez, as propriedades biológicas dessa fração do extrato, e sugerir que se poderia tr a ta r de m aterial fisiològicamente a ti vo. Denominaram-na «glucagon» o que significa «mobiliza dor de glicose» (Kimbal e Gibbs et al, 1923;Collens e Murlin, 1929). E stas descobertas foram logo con firm adas por B ürger e K ram er (1928).…”