2009
DOI: 10.2337/db08-1112
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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

Abstract: The HAPO Study Cooperative Research Group* OBJECTIVE-To examine associations of neonatal adiposity with maternal glucose levels and cord serum C-peptide in a multicenter multinational study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, thereby assessing the Pederson hypothesis linking maternal glycemia and fetal hyperinsulinemia to neonatal adiposity. RESEARCH DESIGN AND METHODS-Eligible pregnantwomen underwent a standard 75-g oral glucose tolerance test between 24 and 32 weeks gestation (as c… Show more

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Cited by 564 publications
(282 citation statements)
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“…The studies fall into four categories: (1) 28 studies (including BiB and Atlantic DIP) 6,61, reported associations between glucose levels (from OGTT or OGCT) split into three or more categories and adverse perinatal outcomes (see Table 7); (2) 20 studies [88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107] reported associations between glucose levels (from OGTT or OGCT) split into two categories with adverse perinatal outcomes (see Table 8) -these studies were mostly comparisons of women with lower glucose levels at OGCT [typically < 140 mg/dl (7.8 mmol/l)] compared with women with higher glucose levels at OGCT; (3) five studies 36,41,65,108,109 reported longer-term outcomes in either mother or offspring (see Table 9) (it was not possible to pool studies reporting longer-term outcomes because they were too diverse); and (4) the remaining five studies [110][111][112][113] did not present numerical data that were suitable for analysis and therefore could not be included in any of the meta-analyses (see Appendix 2, Table 63). One study 114 used a 75-g OGTT in a non-fasted population.…”
Section: Included Studiesmentioning
confidence: 99%
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“…The studies fall into four categories: (1) 28 studies (including BiB and Atlantic DIP) 6,61, reported associations between glucose levels (from OGTT or OGCT) split into three or more categories and adverse perinatal outcomes (see Table 7); (2) 20 studies [88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107] reported associations between glucose levels (from OGTT or OGCT) split into two categories with adverse perinatal outcomes (see Table 8) -these studies were mostly comparisons of women with lower glucose levels at OGCT [typically < 140 mg/dl (7.8 mmol/l)] compared with women with higher glucose levels at OGCT; (3) five studies 36,41,65,108,109 reported longer-term outcomes in either mother or offspring (see Table 9) (it was not possible to pool studies reporting longer-term outcomes because they were too diverse); and (4) the remaining five studies [110][111][112][113] did not present numerical data that were suitable for analysis and therefore could not be included in any of the meta-analyses (see Appendix 2, Table 63). One study 114 used a 75-g OGTT in a non-fasted population.…”
Section: Included Studiesmentioning
confidence: 99%
“…Six studies 22,36,41,65,108,109 reported longer-term and/or anthropometric outcomes, either measures of adiposity or incidence of diabetes. The characteristics of these studies are presented in Table 9.…”
Section: Studies Of Longer-term and Anthropometric Outcomesmentioning
confidence: 99%
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“…High maternal body mass index (BMI), large pregnancy weight gains, and high maternal blood glucose levels are associated with increased risk of giving birth to large infants (Clausen et al, 2005, HAPO Study Cooperative Research Group, 2009), and high birth weight (BW) is associated with OWOB later in life (Yu et al, 2011). Insights into epigenetic mechanisms and fetal programming may imply that preventive measures before or during pregnancy may make important contributions to curtail the future risk of OWOB (Hanson & Gluckman, 2014).…”
Section: Introductionmentioning
confidence: 99%