Hyperfunction of left lateral prefrontal cortex and automatic thoughts in social anxiety disorder: A near-infrared spectroscopy study

Kawashima, Chiwa; Tanaka, Yoshihiro; Inoue, Ayako; Nakanishi, Mari; Okamoto, Keitaro; Maruyama, Yoshihiro; Oshita, Harumi; Ishitobi, Yoshinobu; Aizawa, Saeko; Masuda, Koji; Higuma, Haruka; Kanehisa, Masayuki; Ninomiya, Taiga; Akiyoshi, Jotaro

doi:10.1016/j.jad.2016.07.028

Cited by 23 publications

(22 citation statements)

References 13 publications

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“…Chrysikou and colleagues 27 showed that anodal tDCS over the right DLPFC in healthy individuals decreased approach behavior during conflict, taking into account the anxiety baseline level (subclinical levels of anxiety) of the individuals under study. The results of this study corroborate previous studies, 13,42 which showed that the right DLPFC is involved in anxiety symptoms. This suggests that cathodal stimulation over the right DLPFC may be a treatment option to improve anxiety symptoms in humans.…”

Section: Discussionsupporting

confidence: 92%

<p>Transcranial Direct Current Stimulation in Patients with Anxiety: Current Perspectives</p>

Stein¹,

Medeiros²,

Caumo³

et al. 2020

NDT

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Anxiety is one of the most prevalent and debilitating psychiatric conditions worldwide. Pharmaco-and psycho-therapies have been employed in the treatment of human anxiety to date. Yet, either alone or in combination, unsatisfactory patient outcomes are prevalent, resulting in a considerable number of people whose symptoms fail to respond to conventional therapies with symptoms remaining after intervention. The demand for new therapies has given birth to several noninvasive brain stimulation techniques. Transcranial direct current stimulation (tDCS) has arisen as a promising tool and has been proven to be safe and well tolerated for the treatment of many diseases, including chronic pain, depression, and anxiety. Here, reports of the use of tDCS in anxiety disorders in human patients were reviewed and summarized. A literature search was conducted in mid-2019, to identify clinical studies that evaluated the use of tDCS for the treatment of anxiety behavior. The PubMed, Web of Science, and Scielo and PsycInfo databases were explored using the following descriptors: "anxiety", "anxious behavior", "tDCS", and "transcranial direct current stimulation". Among the selected articles, considerable variability in the type of tDCS treatment applied in interventions was observed. Evidence shows that tDCS may be more effective when used in combination with drugs and cognitive behavioral therapies; however future large-scale clinical trials are recommended to better clarify the real effects of this intervention alone, or in combination with others.

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Section: Discussionsupporting

confidence: 92%

<p>Transcranial Direct Current Stimulation in Patients with Anxiety: Current Perspectives</p>

Stein¹,

Medeiros²,

Caumo³

et al. 2020

NDT

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“…Thus, prefrontal activity markers during chewing and somatic state examinations, such as SCL-90-R, may be useful in clinical settings to analyze the neuro-pathological background in patients complaining of persistent OD. This suggestion is in line with previous research results showing that fNIRS is a functional imaging method that relies on the principal of neurovascular couplings and applicable for evaluation of psychiatric state using prefrontal cortex blood flow in patients with psychiatric disorders [22,23,[58][59][60][61][62][63].…”

Section: Discussionsupporting

confidence: 91%

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

et al. 2018

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Objectives Neuropsychological associations can be considerable in occlusal dysesthesia (OD) patients who routinely complain of persistent occlusal discomfort, and somatization effects in the superior medial prefrontal cortex and the temporal and parietal regions are also present. However, the relationship between physical activity, i.e., chewing, prefrontal cognitive demand, and psychiatric states in OD patients remains unclear. We investigated this relationship in this study. Materials and methods OD patients (n = 15) and healthy control (n = 15; HC) subjects were enrolled in this study. Occlusal contact, chewing activities of the masticatory muscles, prefrontal activities, and psychiatric states such as depression and somatization, of the participants were evaluated. Functional near-infrared spectroscopy was used to determine prefrontal hemodynamics and the Symptom Checklist-90-R was used to score the psychiatric states. Results We observed a significant association between prefrontal deactivation during chewing and somatization subscales in OD patients. Further, there were no significant differences with regard to the occlusal state and chewing physical activities between the OD patients and HC subjects. Conclusions Chewing-related prefrontal deactivation may be associated with somatization severity in OD patients. Clinical relevance fNIRS is a functional imaging method that uses the principal of neuro-vascular couplings. It is applicable for evaluation of psychiatric state based on prefrontal cortex blood flow in patients with psychiatric disorders.

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“…Recent functional brain imaging studies have identified abnormal activities in several brain regions of patients with SAD (Zhu et al, 2017;Doruyter et al, 2018). These brain regions largely belong to the limbic system including the amygdala (Kraus et al, 2018;Figel et al, 2019;Frick et al, 2020), bed nucleus of the stria terminalis (BNST; Figel et al, 2019), and PFC (Buff et al, 2016;Kawashima et al, 2016;Frick et al, 2020). In particular, both near-infrared spectroscopy (Kawashima et al, 2016) and functional magnetic resonance imaging (fMRI) studies (Buff et al, 2016) revealed that hyperactivity of PFC is tightly linked to excessive and long-lasting fear states in patients with SAD.…”

Section: Functions Of the Prefrontal Cortex In Social Fearmentioning

confidence: 99%

“…These brain regions largely belong to the limbic system including the amygdala (Kraus et al, 2018;Figel et al, 2019;Frick et al, 2020), bed nucleus of the stria terminalis (BNST; Figel et al, 2019), and PFC (Buff et al, 2016;Kawashima et al, 2016;Frick et al, 2020). In particular, both near-infrared spectroscopy (Kawashima et al, 2016) and functional magnetic resonance imaging (fMRI) studies (Buff et al, 2016) revealed that hyperactivity of PFC is tightly linked to excessive and long-lasting fear states in patients with SAD. In human, the PFC is mainly composed of four subregions, namely, orbitofrontal cortex (OFC), dorsolateral PFC, ventrolateral PFC, and mPFC (Ko, 2017), which have an important role in the processing of complicated cognitive and executive behaviors (e.g., social behaviors; Amodio and Frith, 2006) as well as emotion (Etkin et al, 2011).…”

Section: Functions Of the Prefrontal Cortex In Social Fearmentioning

confidence: 99%

“…Accumulating evidence from human functional brain imaging studies suggests that the prefrontal cortex (PFC) contributes essentially to the processes of social fear responses (Buff et al, 2016;Kawashima et al, 2016). The PFC is composed of a majority of principal neurons (PNs) and a minority of inhibitory interneurons (INs) which exhibit remarkable diversity in morphology, physiological properties, immunohistochemical characteristics, and connectivity (Kawaguchi and Kubota, 1997;Rudy et al, 2011;Xu et al, 2013;Hattori et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Prefrontal Disinhibition in Social Fear: A Vital Action of Somatostatin Interneurons

Wang

Tian

Zeng

et al. 2020

Front. Cell. Neurosci.

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Social fear and avoidance of social partners and social situations represent the core behavioral symptom of Social Anxiety Disorder (SAD), a prevalent psychiatric disorder worldwide. The pathological mechanism of SAD remains elusive and there are no specific and satisfactory therapeutic options currently available. With the development of appropriate animal models, growing studies start to unravel neuronal circuit mechanisms underlying social fear, and underscore a fundamental role of the prefrontal cortex (PFC). Prefrontal cortical functions are implemented by a finely wired microcircuit composed of excitatory principal neurons (PNs) and diverse subtypes of inhibitory interneurons (INs). Disinhibition, defined as a break in inhibition via interactions between IN subtypes that enhances the output of excitatory PNs, has recently been discovered to serve as an efficient strategy in cortical information processing. Here, we review the rodent animal models of social fear, the prefrontal IN diversity, and their circuits with a particular emphasis on a novel disinhibitory microcircuit mediated by somatostatin-expressing INs in gating social fear behavior. The INs subtype distinct and microcircuit-based mechanism advances our understanding of the etiology of social fear and sheds light on developing future treatment of neuropsychiatric disorders associated with social fear.

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Hyperfunction of left lateral prefrontal cortex and automatic thoughts in social anxiety disorder: A near-infrared spectroscopy study

Cited by 23 publications

References 13 publications

<p>Transcranial Direct Current Stimulation in Patients with Anxiety: Current Perspectives</p>

<p>Transcranial Direct Current Stimulation in Patients with Anxiety: Current Perspectives</p>

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

Prefrontal Disinhibition in Social Fear: A Vital Action of Somatostatin Interneurons

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