Hypereosinophilic Syndrome Presenting with Large Left Ventricular Apical Thrombus and Pulmonary Embolism

Gürgün, Alev; Tülüce, Kamil; Tülüce, Selcen Yakar; Gürgün, Cemil; Bayraktaroğlu, Selen; Tombuloğlu, Murat; Çınar, Cahide Soydaş

doi:10.1111/j.1540-8175.2011.01479.x

Cited by 8 publications

(8 citation statements)

References 7 publications

(17 reference statements)

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“…2,12 Although an exact mechanism how eoshinophilia contributes to thrombosis is unclear, several proteins secreted by eosinophil seem to be responsible. It has been suggested that hypereosinophilia is responsible for the hypercoagulable state in KD and that, in addition, underlying vasculitis might have some roles.…”

Section: Discussionmentioning

confidence: 99%

Kimura Disease Complicated With Bowel Infarction and Multiple Arterial Thromboses in the Extremities

Lee

Hong²

2014

Journal of Clinical Rheumatology

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Kimura disease (KD) is a chronic inflammatory disease characterized by slowly growing subcutaneous nodules in the face and the neck region. Although a concomitant hypercoagulable state can accompany KD, massive thromboses in patients with KD have rarely been reported. Here, we report a case of KD complicated with bowel infarction and multiple arterial thromboses in the upper and lower extremities. The patient underwent bowel resection and was successfully treated with corticosteroid and anticoagulation.

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Section: Discussionmentioning

confidence: 99%

Kimura Disease Complicated With Bowel Infarction and Multiple Arterial Thromboses in the Extremities

Lee

Hong²

2014

Journal of Clinical Rheumatology

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“…We found 16 HES cases [7,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] with cough as the main or only symptom (Case 3-18, Table 2). The overall clinical information is summarized in Table 2.…”

Section: Literature Search Strategy and Termsmentioning

confidence: 99%

Cough in hypereosinophilic syndrome: case report and literature review

Xie

Zhang

et al. 2020

BMC Pulm Med

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Background: Cough and airway eosinophilic inflammation has not been highlighted in hypereosinophilic syndrome (HES). Case presentation: We report 2 further cases and reviewed the clinical features and treatment of HES present with cough from the literature. Both cases were middle age male, presenting with chronic cough, airway eosinophilic inflammation and hyper eosinophilia who have been previous misdiagnosed as cough-variant asthma and failed anti-asthma treatment. PDGFRA fusion gene was confirmed in one case, but not in the other case. Both had evidence of myeloproliferative features. The tyrosine kinase inhibitor, imatinib, resulted in complete resolution of eosinophilia and cough. By searching PubMed, we found 8 HES cohorts of 411 cases between 1975 and 2013, where the incidence of cough was 23.11%. Sixteen case reports of HES presented with cough as predominant or sole symptom, with nine male patients with positive PDGFRA fusion gene, who responded well to imatinib. Six of seven patients, who tested negative for the PDGFRA, responded to systemic glucocorticoids. Conclusions: Cough and airway eosinophilic inflammation is common in some HES patients. PDGFRA+ HES patients present with chronic cough respond well to imatinib. Our case reports indicate that PDGFRA negative HES patients may respond to imatinib as well.

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“…Idiopathic hypereosinophilic syndrome (IHES) is a rare clinical disease that has high morbidity and mortality due to its high tendency for hypercoagulation and associated thromboembolic complications in vital organs such as the heart, brain, lungs, and peripheral vessels. 1 , 2 The heart is frequently involved in IHES. 3 – 5 Chusid et al 6 found that IHES was associated with cardiac thrombosis in up to 41% of patients.…”

Section: Introductionmentioning

confidence: 99%

Imaging Diagnosis for Left Ventricular Thrombosis in Idiopathic Hypereosinophilic Syndrome

Zhu

Zhang

et al. 2014

Medicine

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Idiopathic hypereosinophilic syndrome (IHES) is a rare disease that is frequently associated with cardiac thrombosis and endocardial wall thickness.This case report describes 2 patients who had IHES associated with left ventricular (LV) thrombi. The patients’ symptoms are atypical. Peripheral blood and bone marrow tests showed markedly elevated eosinophils. Electrocardiography showed ischemic changes in both patients. Negative computed tomography (CT) angiography excluded coronary artery stenosis. Transthoracic echocardiography (TTE), conventional multislice spiral CT, gemstone spectral CT, and cardiac magnetic resonance imaging were used to identify the LV intraluminal thrombus and endocardial thickening, and the diagnostic values of each imaging method were analyzed and compared.These patients were clinically diagnosed as “IHES, LV thrombosis, NYHA heart function classification I.”Both patients received oral prednisone and warfarin therapy.At 5 month follow-up, TTE rechecks showed that the size of the LV thrombotic lesion was reduced in the first case but substantially increased in the second case.

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Hypereosinophilic Syndrome Presenting with Large Left Ventricular Apical Thrombus and Pulmonary Embolism

Cited by 8 publications

References 7 publications

Kimura Disease Complicated With Bowel Infarction and Multiple Arterial Thromboses in the Extremities

Kimura Disease Complicated With Bowel Infarction and Multiple Arterial Thromboses in the Extremities

Cough in hypereosinophilic syndrome: case report and literature review

Imaging Diagnosis for Left Ventricular Thrombosis in Idiopathic Hypereosinophilic Syndrome

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