Hypereosinophilic syndrome presenting with eosinophilic colitis, enteritis and cystitis

Amin, Maha M; Hamid, Magdy Abdel; Saba, Sleman

doi:10.1111/j.1443-9573.2005.00231.x

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…In addition, eosinophilic infiltration of the colon is observed in idiopathic hypereosinophilic syndrome [10]. Each of these conditions was satisfactorily ruled out in our patients.…”

Section: Discussionmentioning

confidence: 97%

Childhood Autism and Eosinophilic Colitis

Chen

Girgis²,

El‐Matary³

2010

Digestion

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Background/Aims: The significance of the association between many gastrointestinal pathologies and autism is yet to be discovered. The aim of this report is to highlight an association between autism and microscopic eosinophilic colitis in 2 children. The possible mechanisms that may connect these two conditions are discussed. Methods and Results: A rare association between autism and microscopic eosinophilic colitis in 2 children is reported through retrospective chart review. Common causes of secondary eosinophilic colitis were excluded. Conclusion: This report suggests the possibility of either impaired intestinal barrier function or an aberrant immune system that predisposes autistic children to sensitization to environmental antigens. Large controlled studies are needed to examine this hypothesis.

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“…In addition, eosinophilic infiltration of the colon is observed in idiopathic hypereosinophilic syndrome [10]. Each of these conditions was satisfactorily ruled out in our patients.…”

Section: Discussionmentioning

confidence: 97%

Childhood Autism and Eosinophilic Colitis

Chen

Girgis²,

El‐Matary³

2010

Digestion

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“…We found 4 patients who had HES and EC including the present patient and 14 EC patients who had no etiology and an eosinophil count as described in the report [3,4,5,6,7,8,9,10,11,12,13,14,15]. Of the 14 patients reported as EC, 5 had an eosinophil count of ≥1,500/μl on at least one occasion without apparent cause of eosinophilia, which suggests that these patients had HES (table 1).…”

Section: Resultsmentioning

confidence: 57%

“…There are two case reports of HES which presented with concomitant EC and eosinophilic enterocolitis [3,6]. Another patient had cystitis and granulomatous peritonitis [15].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Cystitis Presented as a Manifestation of Hypereosinophilic Syndrome: A Case Report and Review of the Literature

et al. 2013

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Background: Hypereosinophilic syndrome (HES) is a group of disorders marked by the sustained overproduction of eosinophils, in which eosinophilic infiltration and inflammatory substance release cause damage to multiple organs. Eosinophilic cystitis (EC) is an inflammatory disorder caused by eosinophilic infiltration of the bladder wall. Although EC is often associated with eosinophilia, it has been rarely reported as a manifestation of HES. We report a case of EC as a primary manifestation of HES. The patient was a 27-year-old male with a history of complete intracardiac repair of tetralogy of Fallot who presented with an acute onset of dysuria accompanied by eosinophilia (7.5 × 10³/µl, 60% of white blood cells). Ultrasonography and MRI of the bladder showed a bladder mass, a biopsy of which revealed eosinophilic infiltration and degranulation. Methods: We performed a literature search in PubMed from 2001 to 2012 to find patients with EC who may have had HES. Results: There were 4 patients with HES who had EC including the present case. Of 14 patients reported as EC in whom the eosinophil count was described, 5 had eosinophils of ≥1,500/µl. None of the 5 patients had secondary causes for eosinophilia. Of the 9 patients with definite or probable HES, 7 patients (78%) were male and 5 patients (56%) showed a concomitant eosinophilic gastrointestinal disorder. Conclusion: HES may not be uncommon as the cause of EC. Thorough evaluation and close monitoring are warranted in EC patients with elevated eosinophils.

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“…However, the mechanisms underlying how and why these overproduced eosinophils infiltrate the bladder and cause the specific symptoms remain unclear. It has been hypothesized that eosinophilic tissue damage is associated with the release of major basic protein, eosinophil peroxidase, eosinophil cationic protein and eosinophil-derived neurotoxin (8). In imaging examinations, the bladder wall exhibits diffuse or localized thickening.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic cystitis in a patient with hypereosinophila syndrome: A case report

Jiang

Wang

Jin

et al. 2014

Experimental and Therapeutic Medicine

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Hypereosinophilic syndrome (HES) is a rare disorder that is characterized by hypereosinophilia and organ damage, caused by the infiltration of eosinophils. In rare cases, the urinary bladder may also be involved. The current case report presented a 56-year-old male with gross hematuria and hypereosinophilia. The diagnosis of eosinophilic cystitis associated HES was established. Oral prednisone with a slow tapering regimen was administered as the primary treatment for the patient, which achieved partial hematological remission and complete relief of cystitis during a six-month follow-up period. Although eosinophilic cystitis is not commonly the primary manifestation of HES, eosinophilic cystitis should be taken into consideration following the onset of urinary symptoms in patients with HES.

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Hypereosinophilic syndrome presenting with eosinophilic colitis, enteritis and cystitis

Cited by 9 publications

References 4 publications

Childhood Autism and Eosinophilic Colitis

Childhood Autism and Eosinophilic Colitis

Eosinophilic Cystitis Presented as a Manifestation of Hypereosinophilic Syndrome: A Case Report and Review of the Literature

Eosinophilic cystitis in a patient with hypereosinophila syndrome: A case report

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